Adsorption and Sustained Release of Insulin from Zinc Hydroxyapatite Microparticle with Poly (Lactic Acid) Coating

2008 ◽  
Vol 396-398 ◽  
pp. 507-510 ◽  
Author(s):  
Toru Tonegawa ◽  
Toshiyuki Ikoma ◽  
Tomohiko Yoshioka ◽  
Kazuo Shinozaki ◽  
Nobutaka Hanagata ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Lactic Acid ◽  
Adsorption Isotherm ◽  
Sustained Release ◽  
Outer Layer ◽  
Poly Lactic Acid ◽  
Initial Release ◽  
Apparent Reduction ◽  
Low Crystalline ◽  
Acid Coating

Insulin delivery carriers using low crystalline porous zinc hydroxyapatite (ZnHAp) microparticles with different crystal sizes and novel formulation method of poly (lactic acid) (PLA) have been developed to achieve the sustained-release of insulin. The adsorption isotherm curves of insulin dissolved into acetic acid of pH4.5 onto ZnHAp nanocrystals show non-Langmuir type due to the dissolution of the ZnHAp microparticles; the adsorption amounts were increased with the increase of crystalline sizes. The PLA formulation, coating the outer layer of microparticles, showed the apparent reduction of initial burst for insulin. The amounts of initial release of insulin decreased with the increase of crystalline sizes of ZnHAp, which could be attributed to the different meso-porous structure depending on its crystal sizes.

scholarly journals Sustained Release of Hydrogen Sulfide (H2S) from Poly(Lactic Acid) Functionalized 4-Hydroxythiobenzamide Microparticles to Protect Against Oxidative Damage

2019 ◽  
Vol 47 (8) ◽  
pp. 1691-1700 ◽  
Author(s):  
Anh-Vu Do ◽  
Rasheid Smith ◽  
Phillip Tobias ◽  
Daniel Carlsen ◽  
Erica Pham ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Lactic Acid ◽  
Oxidative Damage ◽  
Sustained Release ◽  
Poly Lactic Acid

Formation the Polypyrrole / Chitosan / Polylactic Acid Microencapsules

2014 ◽  
Vol 881-883 ◽  
pp. 83-86 ◽  
Author(s):  
Hong Ye ◽  
Ying Liu ◽  
Xiang Hong Peng ◽  
Kun Wan ◽  
Feng Chen
Keyword(s):  
Electrical Conductivity ◽  
Acetic Acid ◽  
Lactic Acid ◽  
Polylactic Acid ◽  
Smooth Surface ◽  
Poly Lactic Acid ◽  
Spray Dried

The emulsion of chitosan in acetic acid aqueous and poly lactic acid in chloroform was spray-dried to obtain the chitosan/poly lactic acid microencapsules (CS-PLA). The polypyrrole / chitosan/ polylactic acid microencapsules were prepared by polymerization pyrrole on CS-PLA. The structures and the morphologies of microencapsules were characterized by FTIR, SEM, TGA and four probes technique. The results showed that multilayer polypyrrole were formation on the surface of CS-PLA microencapsules, the microencapsules had 3.0-8.0 μm diameters with smooth surface, and the electrical conductivity value was 1.03×10-3 S/cm.

Poly(lactic acid) microspheres for the sustained release of antiischemic agents

2002 ◽  
Vol 242 (1-2) ◽  
pp. 115-120 ◽  
Author(s):  
A Dalpiaz ◽  
A Scatturin ◽  
B Pavan ◽  
C Biondi ◽  
M.A Vandelli ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Poly Lactic Acid

Poly(lactic acid) microspheres for the sustained release of a selective A1 receptor agonist

2001 ◽  
Vol 73 (2-3) ◽  
pp. 303-313 ◽  
Author(s):  
Alessandro Dalpiaz ◽  
Angelo Scatturin ◽  
Barbara Pavan ◽  
Carla Biondi ◽  
Maria Angela Vandelli ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Receptor Agonist ◽  
Poly Lactic Acid ◽  
A1 Receptor
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