Wnt2 acts as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibits expression of stanniocalcin-1

Angiogenesis ◽  
2009 ◽  
Vol 12 (3) ◽  
pp. 251-265 ◽  
Author(s):  
Diana Klein ◽  
Alexandra Demory ◽  
Francis Peyre ◽  
Jens Kroll ◽  
Cyrill Géraud ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Angiogenic Growth Factor ◽  
Sinusoidal Endothelial Cells

Glycine Prevents Apoptosis of Rat Sinusoidal Endothelial Cells Caused by Deprivation of Vascular Endothelial Growth Factor

Hepatology ◽  
2000 ◽  
Vol 32 (3) ◽  
pp. 542-546 ◽  
Author(s):  
Yan-jun Zhang ◽  
Kenichi Ikejima ◽  
Hajime Honda ◽  
Tsuneo Kitamura ◽  
Yoshiyuki Takei ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Endothelial Cells ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Sinusoidal Endothelial Cells ◽  
Endothelial Growth Factor

Effects of Angiogenic Growth Factor Combinations on Retinal Endothelial Cells☆

2002 ◽  
Vol 74 (4) ◽  
pp. 523-535 ◽  
Author(s):  
Raquel Castellon ◽  
Hamdi K Hamdi ◽  
Ingrid Sacerio ◽  
Annette M Aoki ◽  
M Cristina Kenney ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Angiogenic Growth Factor ◽  
Retinal Endothelial Cells

Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells

Blood ◽  
2004 ◽  
Vol 103 (3) ◽  
pp. 955-962 ◽  
Author(s):  
Gerald W. Prager ◽  
Johannes M. Breuss ◽  
Stefan Steurer ◽  
Judit Mihaly ◽  
Bernd R. Binder
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Endothelial Cells ◽  
Growth Factor ◽  
Endothelial Cell Migration ◽  
Matrix Metalloproteinase 2 ◽  
Vascular Endothelial ◽  
Angiogenic Growth Factor ◽  
Tissue Invasion ◽  
Surface Receptor ◽  
Endothelial Growth Factor

Abstract Vascular endothelial growth factor (VEGF) is the pivotal angiogenic growth factor activating endothelial cells to migrate, proliferate, and form capillary tubes. For an ordered endothelial cell migration, tissue invasion, and degradation of the extracellular matrix, proteolytic machinery is indispensable. Such machinery, suitable for localized proteolysis, is provided by the prourokinase-urokinase-plasmin system. Prourokinase (pro-uPA), the initial component of this system, is, however, synthesized in its inactive precursor form and as such bound to its cellular receptor uPAR. Here we identify a mechanism via which VEGF165 interacting with its receptor VEGFR-2 rapidly induces prourokinase activation that is dependent on a change in integrin affinity, activation of matrix metalloproteinase 2 (MMP-2), and pro-uPA being bound to its surface receptor uPAR. This VEGF-induced pro-uPA activation on endothelial cells is responsible for VEGF-dependent local fibrinolytic activity and might be one of the initial steps in the angiogenic process. (Blood. 2004;103:955-962)

Sign in / Sign up

Export Citation Format

Share Document