ObjectiveWe introduce the Semantic Platform for Adverse Childhood Experiences (ACEs)Surveillance (SPACES). It facilitates the access to the relevant integrated information, enables discovering the causality pathways and assists researchers, clinicians, public health practitioners, social workers, and health organization in studying the ACEs, identifying the trends, as well as planning and implementing preventive and therapeutic strategies.IntroductionAdverse Childhood Experiences (ACEs) have been linked to a variety of detrimental health and social outcomes. In the last 20 years, the association between ACEs with several adult health risk behaviors, conditions, and diseases including suicides, and substance abuse [1], mental health disturbances and impaired memory [2], nervous, endocrine and immune systems impairments [3], and criminal activities [4] have been studied. One of the challenges in studying and timely diagnosis of ACEs is that the links between specific childhood experiences and their health outcomes are not totally clear. Similarly, an integrated dataset builtfrom multiple sources is often required for effective ACEs surveillance. The SPACES project aims at providing a semantic infrastructure to facilitate data sharing and integration and answer causal queries [5] to improve ACEs surveillance.MethodsWe create the ACEs ontology to facilitate the integration of data coming from various distributed sources (e.g. ontologies, databases, surveys, interviews, and literature) and maintain interoperability between the data sources. We re-used some of the existing bio-ontologies in the domain, although they captured the domain’s knowledge in different levels of granularity, e.g., Homeless is defined in SNOMED CT and Medical Dictionary for Regulatory Activities (MedDRA) with different hierarchies, or some related concepts may be disconnected, e.g., SNOMED CT defines Abuse but not Verbal Abuse while MedDRA defines Verbal abuse but not as an Abuse. In order to improve reasoning with the aggregated data, we perform two different kinds of inference. Semantic inference uses the ACEs ontology to creates new conclusions by connecting similar concepts. On the other hand, statistical inference is used to formulate rules that link co-occurring concepts. These two kinds of inference, statistical and semantic, work in tandem and the conclusions from one method can then be used as the basis for the other kind of inference.ResultsThe ACEs Ontology is a unique resource for capturing knowledge in the domain of AdverseChildhood Experiences. The ontology will be openly and freely available via the relevant online community’s portals (e.g. The NCBO BioPortal). The logical validation of the ontology is performed using description logic reasoners. A set of use-case scenarios are designed to demonstrate the feasibility and usability of the ontology for data integration and intelligent query answering.ConclusionsIn this paper, we present the SPACE project that aims to develop a platform to improve adverse childhood experiences surveillance. The tool uses semantic and statistical methods to improve data access, integration, and reasoning.References[1] Vincent J. Felitti, Robert F. Anda, Dale Nordenberg, David F. Williamson, Alison M. Spitz,Valerie Edwards, Mary P. Koss, and James S. Marks. Relationship of childhood abuse and householddysfunction to many of the leading causes of death in adults: The adverse childhood experiences (ace) study. American Journal of Preventive Medicine, 14(4):245–258, 5 1998.[2] Robert F Anda, Vincent J Felitti, J Douglas Bremner, John D Walker, Charles Whitfield, Bruce D Perry, Shanta R Dube, and Wayne H Giles. The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology. European archives of psychiatry and clinical neuroscience, 256(3):174–186, 04 2006.[3] Andrea Danese and Bruce S. McEwen. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & Behavior, 106(1):29 – 39, 2012. Allostasis and Allostatic Load.[4] James Garbarino. Aces in the criminal justice system. Academic Pediatrics, 17(7, Supplement): S32 – S33, 2017. Child Well-Being and Adverse Childhood Experiences in the US.[5] Okhmatovskaia A, Shaban-Nejad A, Lavigne M, Buckeridge DL. Addressing the challenge of encoding causal epidemiological knowledge in formal ontologies: a practical perspective. Stud Health Technol Inform. 2014; 205:1125-9.
Adverse Childhood Experiences, Smoking and Alcohol Use, and Allostatic Load Among People Living with HIV