scholarly journals A novel high CMRR trans-impedance instrumentation amplifier for biomedical applications

2018 ◽  
Vol 98 (2) ◽  
pp. 233-241 ◽  
Author(s):  
Rajasekhar Nagulapalli ◽  
Khaled Hayatleh ◽  
Steve Barker ◽  
Saddam Zourob ◽  
Nabil Yassine ◽  
...  
2008 ◽  
Vol 57 (1-2) ◽  
pp. 11-17 ◽  
Author(s):  
Cesar Augusto Prior ◽  
Cesar Ramos Rodrigues ◽  
André Luiz Aita ◽  
João Baptista dos Santos Martins ◽  
Filipe Costa Beber Vieira

2019 ◽  
Vol 28 (07) ◽  
pp. 1950110 ◽  
Author(s):  
K. Hayatleh ◽  
S. Zourob ◽  
R. Nagulapalli ◽  
S. Barker ◽  
N. Yassine ◽  
...  

This paper describes a high-performance impedance measurement circuit for the application of skin impedance measurement in the early detection of skin cancer. A CMRR improvement technique has been adopted for OTAs to reduce the impact of high-frequency common mode interference. A modified three-OTA instrumentation amplifier (IA) has been proposed to help with the impedance measurement. Such systems offer a quick, noninvasive and painless procedure, thus having considerable advantages over the currently used approach, which is based upon the testing of a biopsy sample. The sensor has been implemented in 65[Formula: see text]nm CMOS technology and post-layout simulations confirm the theoretical claims we made and sensor exhibits sensitivity. Circuit consumes 45[Formula: see text]uW from 1.5[Formula: see text]V power supply. The circuit occupies 0.01954[Formula: see text]mm2 silicon area.


VLSI Design ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yu-Ming Hsiao ◽  
Miin-Shyue Shiau ◽  
Kuen-Han Li ◽  
Jing-Jhong Hou ◽  
Heng-Shou Hsu ◽  
...  

A CMOS amplifier with differential input and output was designed for very high common-mode rejection ratio (CMRR) and low offset. This design was implemented by the 0.35 μm CMOS technology provided by TSMC. With three stages of amplification and by balanced self-bias, a voltage gain of 80 dB with a CMRR of 130 dB was achieved. The related input offset was as low as 0.6 μV. In addition, the bias circuits were designed to be less sensitive to the power supply. It was expected that the whole amplifier was then more independent of process variations. This fact was confirmed in this study by simulation. With the simulation results, it is promising to exhibit an amplifier with high performances for biomedical applications.


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