This paper describes a high-performance impedance measurement circuit for the application of skin impedance measurement in the early detection of skin cancer. A CMRR improvement technique has been adopted for OTAs to reduce the impact of high-frequency common mode interference. A modified three-OTA instrumentation amplifier (IA) has been proposed to help with the impedance measurement. Such systems offer a quick, noninvasive and painless procedure, thus having considerable advantages over the currently used approach, which is based upon the testing of a biopsy sample. The sensor has been implemented in 65[Formula: see text]nm CMOS technology and post-layout simulations confirm the theoretical claims we made and sensor exhibits sensitivity. Circuit consumes 45[Formula: see text]uW from 1.5[Formula: see text]V power supply. The circuit occupies 0.01954[Formula: see text]mm2 silicon area.