Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy

APOPTOSIS ◽  
2007 ◽  
Vol 12 (4) ◽  
pp. 731-741 ◽  
Author(s):  
Silvia Kocanova ◽  
Esther Buytaert ◽  
Jean-Yves Matroule ◽  
Jacques Piette ◽  
Jakub Golab ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Heme Oxygenase ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Heme Oxygenase 1

Ischemia-Induced Up-Regulation of Heme Oxygenase-1 Protects From Apoptotic Cell Death and Tissue Necrosis

2008 ◽  
Vol 150 (2) ◽  
pp. 293-303 ◽  
Author(s):  
Yves Harder ◽  
Michaela Amon ◽  
René Schramm ◽  
Martin Rücker ◽  
Claudia Scheuer ◽  
...  
Keyword(s):  
Cell Death ◽  
Heme Oxygenase ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Heme Oxygenase 1 ◽  
Tissue Necrosis

Tumor-generated nitric oxide as an antagonist of photodynamic therapy

2015 ◽  
Vol 14 (8) ◽  
pp. 1425-1432 ◽  
Author(s):  
Albert W. Girotti
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Treatment Effectiveness ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Inos Inhibitor

PDT upregulates iNOS/NO in cancer cells, which inhibits apoptotic cell death and increases aggressiveness of surviving cells. PDT in the presence of a selective iNOS inhibitor will enhance treatment effectiveness.

scholarly journals Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Seung Hee Choi ◽  
Jaechan Leem ◽  
In-Kyu Lee
Keyword(s):  
Cell Death ◽  
Plasma Levels ◽  
Inflammatory Responses ◽  
Apoptotic Cell ◽  
Dipeptidyl Peptidase ◽  
Apoptotic Cell Death ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Heme Oxygenase 1 ◽  
Nuclear Staining ◽  
Dipeptidyl Peptidase 4

Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used antihyperglycemic agents for the treatment of type 2 diabetes mellitus. Recently, the pleiotropic actions of DPP-4 inhibitors have drawn much attention. In the present study, we aimed to examine whether gemigliptin, a recently developed DPP-4 inhibitor, could protect against cisplatin-induced nephrotoxicity. We showed that pretreatment with gemigliptin attenuated cisplatin-induced renal dysfunction, as shown by analysis of plasma creatinine levels and blood urea nitrogen and histological damage. Elevated plasma levels of active glucagon-like peptide-1 were observed in gemigliptin-pretreated mice after cisplatin treatment, compared to that in cisplatin alone-treated mice. Gemigliptin attenuated cisplatin-induced apoptotic cell death, as assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and Western blot analysis in the kidneys. Gemigliptin also decreased the plasma levels of tumor necrosis factor-αand monocyte chemoattractant protein-1 and attenuated nuclear staining of nuclear factor kappa-B p65 in the kidneys. In addition, gemigliptin increased the protein expression of heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) in the kidneys of cisplatin-treated mice. Taken together, these results suggest that pretreatment with gemigliptin protects against cisplatin-induced nephrotoxicity in mice, possibly via inhibition of apoptotic cell death and inflammatory responses through induction of HO-1 and NQO1 expression.

Induction of apoptotic cell death by photodynamic therapy in human keratinocytes

1998 ◽  
Vol 43 (2) ◽  
pp. 143-149 ◽  
Author(s):  
A Ketabchi ◽  
A MacRobert ◽  
P.M Speight ◽  
J.H Bennett
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Apoptotic Cell ◽  
Human Keratinocytes ◽  
Apoptotic Cell Death
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