Background:
Controlled drug delivery systems can maintain the concentration of drugs
in the exact sites of the body within the optimum range and below the toxicity threshold, improving
therapeutic efficacy and reducing toxicity.
Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems
due to high biocompatibility, in vivo biodegradability and low toxicity.
Methods:
Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and
loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR,
TGA, TEM and textural analyses.
Results:
We obtained promising results for controlled drug release using the novel MCF material.
The application of these materials in KETO release is innovative, achieving an initial high release
rate and then maintaining a constant rate at high times. This allows keeping drug concentration
within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that
need a rapid response. The release of KETO/MCF was compared with other containers of KETO
(KETO/SBA-15) and commercial tablets.
Conclusion:
The best model to fit experimental data was Ritger-Peppas equation. Other models
used in this work could not properly explain the controlled drug release of this material. The
predominant release of KETO from MCF was non-Fickian diffusion.
Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle.