Effect of Delta-Sleep-Inducing Peptide on Activity of Enzymes of Biogenic Amine Metabolism in the Brain of Wistar and August Rats

2005 ◽  
Vol 140 (5) ◽  
pp. 514-516 ◽  
Author(s):  
E. L. Dovedova ◽  
D. A. Khrustalev ◽  
R. M. Khudoerkov
Keyword(s):  
Biogenic Amine ◽  
August Rats ◽  
Wistar And August Rats ◽  
Amine Metabolism ◽  
Delta Sleep ◽  
Activity Of Enzymes ◽  
The Brain ◽  
Delta Sleep Inducing Peptide

scholarly journals Endogenous anticonvulsants: Neuropeptide Y and delta sleep inducing peptide

2008 ◽  
Vol 61 (5-6) ◽  
pp. 252-255
Author(s):  
Olivera Stanojlovic ◽  
Dragan Hrncic ◽  
Tatjana Radosavljevic
Keyword(s):  
Neuropeptide Y ◽  
Convulsive Activity ◽  
Brain Excitability ◽  
Delta Sleep ◽  
The Brain ◽  
Delta Sleep Inducing Peptide

Introduction The same neuropeptides regulate both cycle sleep-wake and excitability of the brain. Conclusion Literature data together with our results support the idea that delta sleep - inducing peptide and neuropeptide Y could represent one of the factors of the endogenous stabilization of brain excitability and potent antiepileptic in generalized metaphit-induced audiogenic convulsive activity. The same holds true for DSIP analogues.

scholarly journals Simulation of biogenic amine metabolism in the brain

1974 ◽  
Vol 144 (2) ◽  
pp. 353-360 ◽  
Author(s):  
A J Turner ◽  
J A Illingworth ◽  
K F Tipton
Keyword(s):  
Steady State ◽  
Biogenic Amines ◽  
Biogenic Amine ◽  
Simulated Model ◽  
Amine Concentration ◽  
Amine Metabolism ◽  
Low Concentrations ◽  
Using Data ◽  
The Individual ◽  
The Brain

The metabolism of a number of biogenic amines has been simulated by using data obtained from studies of the individual enzymes from pig brain. It is shown that β-hydroxylated amines such as noradrenaline and octopamine are metabolized primarily to the alcoholic metabolite whereas amines lacking this group [e.g. dopamine (3,4-dihydroxyphenethylamine) and 5-hydroxytryptamine] are metabolized at low concentrations to give the corresponding acid. Increase in the amine concentration results in an increase in the proportion of the alcoholic metabolite formed and this may in part account for the effects of the drug reserpine on amine metabolism. The effects of disulfiram (Antabuse) and ethanol (acting through its metabolite acetaldehyde) on amine metabolism may be understood in terms of this simulated model. It is shown that drugs that affect this system also cause alterations in the steady-state concentrations of the intermediate aldehydes and the possible implications of this are discussed.

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