Manifestation of Adaptive Changes during Combined Development of Postinfarction Remodeling of the Heart and Diabetes Mellitus

Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, the degree of left ventricular hypertrophy, and the size of scar zone. It was shown that in combined development of postinfarction cardiac remodeling of heart (PICR) with diabetes mellitus (DM) animal body weight decreased in less degree than in diabetic rats. Animals with combined pathology had no heart hypertrophy. The amplitude of extrasystolic contractions in rats with PICR combined with DM had no differences compared to the control group. In myocardium of rats with PICR combined with DM postextrasystolic potentiation was observed in contrast with the rats with PICR alone. The rats with combined pathology had the decreased value of TBA-active products. Thus, the results of study showed that induction of DM on the stage of the development of postinfarction remodeling increases adaptive ability of myocardium. It is manifested in inhibition of increase of LPO processes activity and maintaining of force-interval reactions of myocardium connected with calcium transport systems of sarcoplasmic reticulum of cardiomyocytes.

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Flow motion dynamics of microvascular blood flow and oxygenation: Evidence of adaptive changes in obesity and type 2 diabetes mellitus/insulin resistance

Microcirculation ◽

10.1111/micc.12331 ◽

2017 ◽

Vol 24 (2) ◽

pp. e12331 ◽

Cited By ~ 16

Author(s):

Geraldine F. Clough ◽

Katarzyna Z. Kuliga ◽

Andrew J. Chipperfield

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Blood Flow ◽

Type 2 Diabetes Mellitus ◽

Microvascular Blood Flow ◽

Adaptive Changes ◽

Flow Motion ◽

Motion Dynamics

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Morphofunctional reorg anisation of intraorg an vessels of rat’s large salivary glands in the experimental diabetes mellitus

Medical and Clinical Chemistry ◽

10.11603/mcch.2410-681x.2016.v0.i1.6282 ◽

2016 ◽

Author(s):

I. M. Yavorska-Skrabut

Keyword(s):

Diabetes Mellitus ◽

Salivary Glands ◽

Experimental Diabetes ◽

Experimental Diabetes Mellitus ◽

Small Arteries ◽

Adaptive Changes ◽

Submandibular Glands ◽

Vascular Lumen ◽

White Rats ◽

Further Development

There was studied the morphofunctional reorganization of the intraorgan vessels of parotid and submandibular glands of white rats with experimental hyperglycemia duration of 1, 2 and 3 months. There was established the development of hyperglycemia and presence of adaptive changes in early terms of observation that appears with constriction of small arteries while expanding of the larger caliber vascular lumen. With increasing duration of hyperglycemia, progressing of vasoconstriction and further development and deepening of destructive and sclerotic changes in vessels of parotid and submandibular glands were established.

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Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus

Journal of Child Psychology and Psychiatry ◽

10.1017/s0021963098002480 ◽

1998 ◽

Vol 39 (5) ◽

pp. 663-668 ◽

Cited By ~ 53

Author(s):

Harry N. Bawden ◽

Aidan Stokes ◽

Carol S. Camfield ◽

Peter R. Camfield ◽

Sonia Salisbury

Keyword(s):

Diabetes Mellitus ◽

Peer Relationship ◽

Tourette’S Disorder ◽

Relationship Problems ◽

Tourette's Disorder

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Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120102 ◽

1985 ◽

Vol 43 ◽

pp. 682-683

Author(s):

Bruce R. Pachter

Keyword(s):

Diabetes Mellitus ◽

Peripheral Nerves ◽

Sudden Onset ◽

Extraocular Muscles ◽

Diabetic Patients ◽

Oculomotor Palsy ◽

Third Nerve Palsy ◽

Patients With Diabetes ◽

Intramuscular Nerve ◽

Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

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