Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats

2008 ◽  
Vol 9 (3) ◽  
pp. 153-162 ◽  
Author(s):  
Rameshwar Singh ◽  
Jenny Kiloung ◽  
Sangeeta Singh ◽  
Deepak Sharma
Keyword(s):  
Oxidative Stress ◽  
Sleep Deprivation ◽  
Paradoxical Sleep ◽  
Brain Regions ◽  
Paradoxical Sleep Deprivation ◽  
Oxidative Stress Parameters ◽  
Old Rats ◽  
Stress Parameters

Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

2016 ◽  
Vol 99 ◽  
pp. 79-86 ◽  
Author(s):  
Luiz K.S. Kanazawa ◽  
Débora D. Vecchia ◽  
Etiéli M. Wendler ◽  
Palloma de A.S. Hocayen ◽  
Francislaine A. dos Reis Lívero ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sleep Deprivation ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation ◽  
Brain Oxidative Stress

Does paradoxical sleep deprivation and cocaine induce penile erection and ejaculation in old rats?

2002 ◽  
Vol 7 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Monica L. Andersen ◽  
Magda Bignotto ◽  
Ricardo Borges Machado ◽  
Sergio Tufik
Keyword(s):  
Sleep Deprivation ◽  
Penile Erection ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation ◽  
Old Rats

scholarly journals EFFECT OF TOCOTRIENOL PRETREATMENT ON EX VIVO SUPEROXIDE AND PEROXIDE HANDLING CAPACITIES (SPHC) OF RAT SERUM AND BRAIN

2017 ◽  
Vol 9 (3) ◽  
pp. 116
Author(s):  
Pitchaiah Dasari ◽  
Anandamurali R. ◽  
Prasunpriya Nayak
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Ex Vivo ◽  
Reduced Glutathione ◽  
Temporal Cortex ◽  
Antioxidant Property ◽  
Brain Regions ◽  
Rat Serum ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Objective: Tocotrienol (TT), a constituent of vitamin E, present only in selected seed oil. Because of the isoprenoid side chain, antioxidant property of tocotrienol is recently highlighted. Application of tocotrienol is also proven to be neuroprotective. The current study was aimed to evaluate the effect of tocotrienol pretreatment on the serum and brain oxidative stress parameters and oxidant handling capacities.Methods: Male albino Wistar rats were treated with tocotrienol (10 mg/day) for two weeks and maintained for the next four weeks. Levels of reduced glutathione and lipid peroxidation and activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase were estimated fortnightly in serum. After sacrifice, oxidative stress parameters were measured in the frontal cortex, temporal cortex, thalamic area, hippocampus and cerebellum. Glutathione-dependent and glutathione-independent superoxide and peroxide handling capacities (SPHC) were calculated for serum and brain regions. Data collected from both the groups are statistically processed with Kruskal-Wallis test and Mann-Whitney pairwise comparisons.Results: Significant impacts of TT treatment have been observed in terms of growth and water intake. Serum SPHC (Glutathione-independent) has been found to be reduced significantly immediately after the TT treatment. Region-specific alterations in oxidative stress parameters have also been observed after 4 w of supplementation. Global reductions in reduced glutathione and lipid peroxidation have been observed in the brain without any alteration in the SPHC.Conclusion: From the results, it can be suggested that the tocotrienol pretreatment possibly be used as neuroprotective measure particularly against oxidative stress. In addition, the antioxidant impacts of TT were found to be maintained for a longer period in brain regions, even though it was not so in the case of serum.

scholarly journals Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats

2021 ◽  
Vol 410 ◽  
pp. 115351
Author(s):  
Prasada Rao S. Kodavanti ◽  
Matthew Valdez ◽  
Judy E. Richards ◽  
Datonye I. Agina-Obu ◽  
Pamela M. Phillips ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Middle Age ◽  
Brain Regions ◽  
Brown Norway ◽  
Oxidative Stress Parameters ◽  
Induced Changes ◽  
Norway Rats ◽  
Stress Parameters

scholarly journals Differential effects of paradoxical sleep deprivation on memory and oxidative stress

2014 ◽  
Vol 387 (5) ◽  
pp. 399-406 ◽  
Author(s):  
Alisson Menezes Araujo Lima ◽  
Veralice Meireles Sales de Bruin ◽  
Emiliano Ricardo Vasconcelos Rios ◽  
Pedro Felipe Carvalhedo de Bruin
Keyword(s):  
Oxidative Stress ◽  
Sleep Deprivation ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation ◽  
Differential Effects ◽  
And Oxidative Stress

Absence of oxidative stress following paradoxical sleep deprivation in rats

1997 ◽  
Vol 235 (1-2) ◽  
pp. 25-28 ◽  
Author(s):  
Vânia D'Almeida ◽  
Débora C Hipólide ◽  
Lı́gia A Azzalis ◽  
Letı́cia L Lobo ◽  
Virgı́nia B.C Junqueira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sleep Deprivation ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation

Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Taye J. Lasisi ◽  
Shehu-Tijani T. Shittu ◽  
Jude I. Abeje ◽  
Kehinde J. Ogunremi ◽  
Seyyid A. Shittu
Keyword(s):  
Oxidative Stress ◽  
Sleep Deprivation ◽  
Wistar Rats ◽  
Paradoxical Sleep ◽  
Salivary Secretion ◽  
Control Group ◽  
Paradoxical Sleep Deprivation ◽  
Sod Activity ◽  
Submandibular Glands ◽  
Male Wistar Rats

Abstract Objectives Paradoxical sleep deprivation has been associated with impaired salivary secretion in rats. However, the mechanism that underlies this is not known. Therefore, this study assessed salivary and serum oxidative stress levels following paradoxical sleep deprivation in rats. Methods Twenty-one male Wistar rats randomly divided into three groups of seven rats each as; Control (C); partial sleep-deprived (PSD); and total sleep-deprived (TSD) were used. Malondialdehyde (MDA) concentration, Superoxide dismutase (SOD), and catalase activities were evaluated in saliva, serum, and submandibular glands after seven days of sleep deprivation. Data were expressed as mean ± standard error of the mean and analyzed using one-way ANOVA, Tukey HSD post hoc, and Pearson’s correlation tests. Results Serum MDA levels were significantly higher in both the TSD and PSD groups compared to the control group whereas only the TSD group showed higher submandibular MDA levels compared to the PSD group and the control group. Submandibular SOD activity was significantly lower in both the TSD and PSD groups compared to the control group. Serum catalase activity was significantly lower in the TSD group only compared to the control group. Conclusions These results have demonstrated for the first time that paradoxical sleep deprivation was associated with changes in the oxidant/antioxidant defense system in the submandibular salivary glands of male Wistar rats which may contribute to impairment in salivary secretion.

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