scholarly journals Male and female breast cancer: the two faces of the same genetic susceptibility coin

2021 ◽  
Author(s):  
Susana Nunes Silva ◽  
Bruno Costa Gomes ◽  
Saudade André ◽  
Ana Félix ◽  
António Sebastião Rodrigues ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Management Strategies ◽  
Female Breast Cancer ◽  
Male And Female ◽  
Male Cohort ◽  
Males And Females ◽  
The Difference ◽  
Repair Genes ◽  
Prognostic And Predictive Markers

Abstract Background Breast cancer (BC) is the most common cancer in women. In contrast, male BC is about 100 times less common than in women, being considered a rare disease. Male BC may be a distinctive subtype of BC and available data seems to indicate that male BC has a higher dependence on genetic variants than female BC. Nevertheless, the same prognostic and predictive markers are used to determine optimal management strategies for both male and female BC. Several studies have assessed the role of genetic polymorphisms (SNPs) in DNA repair genes in female BC susceptibility. However, data on male BC is scarce. Thus, the current study aimed to assess the role of SNPs in XRCC1, MUTYH and TP53 genes in a male cohort of BC, and, in addition, compare the male data with matched results previously genotyped in female BC patients. Methods The male BC cohort was genotyped through Real-Time PCR using TaqMan Assays for several SNPs previously analysed in Portuguese female BC patients. Results The results obtained indicate significant differences in BC susceptibility between males and females for the XRCC1 rs1799782, MUTYH rs3219489 and TP53 rs1042522 and rs8064946 variants. Conclusions In males, XRCC1 and TP53 variants, when in heterozygosity, seem to be related with lower susceptibility for BC, contrasting with higher susceptibility for a MUTYH variant in females. These findings may help to explain the difference in incidence of BC between the two sexes.

scholarly journals Role of Age and Sex in Chronic Thyroiditis in Rats Fed 3'-Methyl-4-Dimethylaminoazobenzene

1976 ◽  
Vol 13 (4) ◽  
pp. 295-302 ◽  
Author(s):  
M. D. Reuber ◽  
E. L. Glover
Keyword(s):  
Female Rats ◽  
Male Rats ◽  
Deficient Diet ◽  
Chronic Thyroiditis ◽  
Male And Female ◽  
Low Protein ◽  
Males And Females ◽  
The Difference ◽  
Age And Sex

Inbred male and female Buffalo strain rats were started at 4, 8, 12, 24, or 52 weeks of age on 0.06% 3'-methyl-4-dimethylaminoazobenzene in a low-protein, choline-deficient diet. Eight-week-old males and females were the most susceptible to the development of chronic thyroiditis, but females were more susceptible than the males. Female rats of other ages developed a slightly higher incidence of thyroiditis than the male rats, the difference being most noticeable for rats 12 weeks old.

scholarly journals 165P Comparison of male and female breast cancer in reference hospital in Mexico

2021 ◽  
Vol 32 ◽  
pp. S90-S91
Author(s):  
G. Sanchez ◽  
A. Gutierrez ◽  
J.C. Jímenez ◽  
R. Correa ◽  
J.A. Alegría Baños ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Female Breast Cancer ◽  
Male And Female ◽  
Female Breast ◽  
Reference Hospital

scholarly journals Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer

2007 ◽  
Vol 156 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Kalliopi Pazaitou-Panayiotou ◽  
Theodore Kelesidis ◽  
Iosif Kelesidis ◽  
Athina Kaprara ◽  
Jennifer Blakeman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Female Breast Cancer ◽  
Cancer Risk Factors ◽  
Female Breast ◽  
Igf I ◽  
Breast Cancer Risk Factors ◽  
Igfbp 3

Objective: Several components of the GH and IGF systems have been implicated in the development of malignancies. All components of these hormonal systems have never been jointly evaluated in female breast cancer, and previous studies have not examined the role of IGF-binding proteins (IGFBP-4, IGFBP-6) or GH-binding protein (GHBP). Design: Hospital-based case–control study. Methods: In this sample of primarily postmenopausal women, we obtained serum measures of IGF-I, IGF-II, and binding proteins IGFBP-1, IGFBP-3, IGFBP-4, IGFBP-6, as well as GHBP, insulin, and leptin from 74 breast cancer cases and 76 control subjects. Results: In crude analyses, we found lower age-standardized mean IGF-I, IGFBP-3, IGFBP-4, IGFBP-6, and higher IGFBP-1 and GHBP in breast cancer cases when compared with controls. Multivariate models mutually adjusted for other GH–IGF system components and classical breast cancer risk factors demonstrated an inverse association between IGFBP-3 and risk of breast cancer (odds ratio (OR) = 0.2, P < 0.01) and a direct association between GHBP and disease risk (OR = 3.3, P < 0.01). No significant associations were detected in multivariate analyses among IGF-I, IGF-II or IGFBP-1, IGFBP-4, IGFBP-6 with risk of breast cancer, indicating that these factors may not have effects independent of and/or comparable with IGFBP-3 and GHBP. Conclusions: These results support a protective role of IGFBP-3 and demonstrate for the first time an increased risk of breast cancer with higher GHBP, after accounting for variation in IGFs, IGFBPs, and classical breast cancer risk factors.

scholarly journals Suicide Notes: Exaggerations by Males and Females

2020 ◽  
Vol 1 (1) ◽  
pp. 1-10
Author(s):  
Purbo Kusumastuti ◽  
Aulia Apriana ◽  
Yazid Basthomi
Keyword(s):  
Gender Differences ◽  
Gender Stereotypes ◽  
Language Production ◽  
Positive Emotions ◽  
Negative Emotions ◽  
Male And Female ◽  
Suicide Notes ◽  
Males And Females ◽  
The Difference ◽  
Female Subjects

Touching into the gender differences between males and females in expressing the use of exaggeration expressions, this study analyzes the relevant data using the LIWC tool, the HIP method, and the deficit and difference theories. This study found that in relation to the gender stereotypes, both males and females speak differently, yet also demonstrate similarities. Both the male and female subjects express emotions equally in the language production; yet, the negative emotions are dominated by the males, and the positive emotions are dominated by the females. The difference of emotion productions influences the differences in the males’ production of exaggeration expressions, such as empty adjectives, italic expressions, and hyperbole by the female subjects.  

scholarly journals 71P Role of radiomics in predicting molecular phenotypes of female breast cancer

2020 ◽  
Vol 31 ◽  
pp. S39
Author(s):  
A. Jajodia ◽  
A. Gupta ◽  
A. Mehta ◽  
A. Chaturvedi ◽  
A. Rao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Female Breast Cancer ◽  
Female Breast ◽  
Molecular Phenotypes

Response of summerform pear psylla (Hemiptera: Psyllidae) to male- and female-produced odors

2011 ◽  
Vol 143 (3) ◽  
pp. 245-253 ◽  
Author(s):  
Christelle Guédot ◽  
David R. Horton ◽  
Peter J. Landolt
Keyword(s):  
Chemical Signals ◽  
Male Attraction ◽  
Male And Female ◽  
Volatile Chemicals ◽  
Sex Attraction ◽  
Pear Psylla ◽  
Males And Females

AbstractWe examined the role of chemical signals in sex attraction of pear psylla, Cacopsylla pyricola (Förster), assessing the response of summerform male and female psyllids to male- and female-produced volatile chemicals. Male psyllids were attracted to odors from live females and pentane extracts of females. Extracts of females were as attractive to males as live females, suggesting that the female-produced volatile chemicals responsible for male attraction might be isolated by extracting females with pentane. Females were not attracted to odorants from live females and tended to avoid odorants from extracts of females. Furthermore, summerform males and females were not attracted or repelled by male-produced odorants from live males or extracts of males. Results of olfactometer assays using male summerform C. pyricola are consistent with results from earlier studies with the winterform morphotype of this species.

scholarly journals Do spermathecal morphology and inter-mating interval influence paternity in the polyandrous beetle Tribolium castaneum?

Behaviour ◽  
2006 ◽  
Vol 143 (5) ◽  
pp. 643-658 ◽  
Author(s):  
Ludovic Arnaud ◽  
Giorgina Bernasconi ◽  
Yves Brostaux ◽  
Eric P. Meyer
Keyword(s):  
Sperm Competition ◽  
Tribolium Castaneum ◽  
Reproductive Tract ◽  
Sperm Storage ◽  
Female Reproductive Tract ◽  
Phenotypic Marker ◽  
Male And Female ◽  
The Difference ◽  
Different Strains

AbstractIn polyandrous insects, postcopulatory sexual selection is a pervasive evolutionary force favouring male and female traits that allow control of offspring paternity. Males may influence paternity through adaptations for sperm competition, and females through adaptations facilitating cryptic female choice. Yet, the mechanisms are often complex, involving behaviour, physiology or morphology, and they are difficult to identify. In red flour beetles (Tribolium castaneum), paternity varies widely, and evidence suggests that both male and female traits influence the outcome of sperm competition. To test the role of spermathecal morphology and of sperm storage processes on the outcome of sperm competition, we mated each of 26 virgin females with two males, one of which carrying a phenotypic marker to assign offspring paternity. We manipulated the interval between mating with the first and the second male, to create different conditions of sperm storage (overlapping and non-overlapping) in the female reproductive tract. To investigate the role of sperm storage more closely, we examined the relationship between paternity and spermathecal morphology in a subset of 14 experimental females. In addition, we also characterized variation in spermathecal morphology in three different strains, wildtype, Chicago black and Reindeer. No significant influence of the intermating interval was found on the paternity of the focal male, although the direction of the difference was in the expected direction of higher last male paternity for longer intervals. Moreover, paternity was not significantly associated with spermathecal morphology, although spermathecal volume, complexity, and tubule width varied significantly and substantially among individuals in all investigated strains.

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