Longitudinal study of inflammatory, behavioral, clinical, and psychosocial risk factors for chemotherapy-induced peripheral neuropathy

Author(s):  
Ian R. Kleckner ◽  
Todd A. Jusko ◽  
Eva Culakova ◽  
Kaitlin Chung ◽  
Amber S. Kleckner ◽  
...  
2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
David P. Farrington ◽  
Henriette Bergstrøm

Purpose Previous research has indicated that low resting heart rate (RHR), measured at age 18, predicts later psychopathy, and that high RHR acts as a protective factor in nullifying the influence of several psychosocial risk factors in predicting later antisocial and criminal outcomes. This paper aims to investigate high RHR as a protective factor against age 8–10 psychosocial risk factors in predicting psychopathy factors at age 48 (measured by the PCL:SV). Design/methodology/approach Data collected in the Cambridge Study in Delinquent Development are analyzed. This is a prospective longitudinal study of 411 London males from age 8 to age 61. Findings This paper first reports the age 8–10 psychosocial risk factors that predict the interpersonal/affective Factor 1 and the lifestyle/antisocial Factor 2. Then interaction effects with high RHR are studied. The results indicate that high RHR acts as a protective factor against a convicted father and a depressed mother in predicting both psychopathy factors. It also protected against harsh discipline, large family size, low verbal IQ, high hyperactivity, poor parental supervision and a high delinquency-rate school in predicting one of these psychopathy factors, and against a convicted mother in a sensitivity analysis. Originality/value This is the first ever longitudinal study showing that high RHR acts as a protective factor in the prediction of psychopathy. The replicated results with different antisocial outcomes show that more research is warranted on the protective effects of high RHR.


2016 ◽  
Vol 34 (2) ◽  
pp. 217-224 ◽  
Author(s):  
Juliana Pedro ◽  
Maria Pedro Sobral ◽  
Joana Mesquita-Guimarães ◽  
Carla Leal ◽  
Maria E. Costa ◽  
...  

Crisis ◽  
2011 ◽  
Vol 32 (5) ◽  
pp. 283-287 ◽  
Author(s):  
L. F. Chan ◽  
T. Maniam ◽  
A. S. Shamsul

Background: Depressed inpatients constitute a high-risk population for suicide attempts. Aims: To describe the interactions of clinical and psychosocial risk factors influencing suicide attempts among a Malaysian sample of depressed inpatients. Methods: Seventy-five subjects were diagnosed with a depressive disorder according to the Structured Clinical Interview for DSM-IV Axis I Disorders-Clinical Version (SCID-CV). Data on suicide attempts, suicidal ideation (Scale for Suicidal Ideation, SSI), depression severity (Beck’s Depression Inventory, BDI), recent life-event changes (Social Readjustment Rating Scale, SRRS), sociodemographic and other relevant clinical factors were collected. Results: A third of the subjects presented after a current suicide attempt. Significant factors for a current suicide attempt were race, religion, recent life-event changes, suicidal ideation, and alcohol use disorder. Independent predictive risk factors for a current suicide attempt were Chinese race, recent marital separation, major mortgage or loans, and being newly diagnosed with depression. Any recent change in personal habits was shown to be a protective factor against current suicide attempt. Age and gender were nonsignificant factors. Conclusions: The findings are generally consistent with existing studies and highlight the role of psychosocial risk factors.


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