scholarly journals Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability

2021 ◽  
Author(s):  
Alberto Granato ◽  
Adalberto Merighi
Keyword(s):  
Intellectual Disability ◽  
Mental Disorders ◽  
Cognitive Deficits ◽  
Pyramidal Neurons ◽  
Dendritic Tree ◽  
Different Types ◽  
Different Parts ◽  
Neocortical Pyramidal Neurons

AbstractPyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here, we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction.

scholarly journals Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability

2021 ◽  
Author(s):  
Alberto Granato ◽  
Adalberto Merighi
Keyword(s):  
Intellectual Disability ◽  
Mental Disorders ◽  
Cognitive Deficits ◽  
Pyramidal Neurons ◽  
Dendritic Tree ◽  
Different Types ◽  
Different Parts ◽  
Neocortical Pyramidal Neurons

Abstract Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction.

Transdiagnostic Approaches With Children

2018 ◽  
Author(s):  
Andrea B. Temkin ◽  
Mina Yadegar ◽  
Christine Cho ◽  
Brian C. Chu
Keyword(s):  
Mental Disorders ◽  
Externalizing Symptoms ◽  
Case Conceptualization ◽  
Common Elements ◽  
Transdiagnostic Treatment ◽  
Treatment Models ◽  
Different Types ◽  
Internalizing And Externalizing ◽  
Internalizing And Externalizing Symptoms

In recent years, the field of clinical psychology has seen a growing movement toward the research and development of transdiagnostic treatments. Transdiagnostic approaches have the potential to address numerous issues related to the development and treatment of mental disorders. Among these are the high rates of comorbidity across disorders, the increasing need for efficient protocols, and the call for treatments that can be more easily disseminated. This chapter provides a review of the current transdiagnostic treatment approaches for the treatment of youth mental disorders. Three different types of transdiagnostic protocols are examined: mechanism-based protocols, common elements treatments, and general treatment models that originated from single-disorder approaches to have broader reach. A case study illuminates how a mechanism-based approach would inform case conceptualization for a client presenting with internalizing and externalizing symptoms and how a transdiagnostic framework translates into practice.

scholarly journals Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Jesús David Urbano-Gámez ◽  
Juan José Casañas ◽  
Itziar Benito ◽  
María Luz Montesinos
Keyword(s):  
Intellectual Disability ◽  
Pyramidal Neurons ◽  
Metabotropic Glutamate Receptor ◽  
Therapeutic Potential ◽  
Mammalian Target Of Rapamycin ◽  
Memory Deficits ◽  
Prenatal Treatment ◽  
Hippocampal Pyramidal Neurons ◽  
Metabotropic Glutamate ◽  
Mushroom Spines

AbstractDown syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory deficits. We have previously reported hippocampal mTOR (mammalian target of rapamycin) hyperactivation, and related plasticity as well as memory deficits in Ts1Cje mice, a DS experimental model. Here we characterize the proteome of hippocampal synaptoneurosomes (SNs) from these mice, and found a predicted alteration of synaptic plasticity pathways, including long term depression (LTD). Accordingly, mGluR-LTD (metabotropic Glutamate Receptor-LTD) is enhanced in the hippocampus of Ts1Cje mice and this is correlated with an increased proportion of a particular category of mushroom spines in hippocampal pyramidal neurons. Remarkably, prenatal treatment of these mice with rapamycin has a positive pharmacological effect on both phenotypes, supporting the therapeutic potential of rapamycin/rapalogs for DS intellectual disability.

Study of Mental Disorder Prediction Model approaches its issues and Challenges

2021 ◽  
Vol 23 (07) ◽  
pp. 831-840
Author(s):  
Avani S Bhuva ◽  
◽  
Dr. Dhirendra Mishra ◽  
Keyword(s):  
Mental Disorders ◽  
Mental Disorder ◽  
Health Issues ◽  
Human Beings ◽  
Major Health ◽  
The World ◽  
Different Types ◽  
Prediction Systems ◽  
Voice Modulation ◽  
Society Today

Mental disorder is becoming one of the major health issues in society today. (WHO) depression will be the leading mental disorder all over the world by 2030. The timely prediction of such disorders is very essential for maintaining the health of human beings. These mental disorders are associated with different symptoms, some of these symptoms are visible in the form of facial expressions, gestures, change in voice modulation, etc. and some of them even cannot be noticed by naked eyes. Therefore, it is highly important to collect appropriate verbal and non-verbal symptom details about any individual along with using best-suited algorithms for accurate prediction using information technology. This paper explores different types of such symptoms associated with different types of mental disorders, their causes, and existing prediction-based solutions. The paper further presents the critical analysis of these aspects and proposes usages of biometrics-based traits for building better prediction systems for mental disorders.

Cognitive deficits in problematic drinkers with and without mild to borderline intellectual disability

2016 ◽  
Vol 22 (1) ◽  
pp. 5-17 ◽  
Author(s):  
Neomi van Duijvenbode ◽  
Robert Didden ◽  
Joanne EL VanDerNagel ◽  
Hubert PLM Korzilius ◽  
Rutger CME Engels
Keyword(s):  
Intellectual Disability ◽  
Alcohol Use ◽  
Cognitive Deficits ◽  
Alcohol Use Disorder ◽  
Short Form ◽  
Adult Intelligence Scale ◽  
Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Disorder Identification ◽  
Wechsler Adult Intelligence

We examined cognitive deficits in problematic drinkers with and without mild to borderline intellectual disability (MBID). Problematic drinkers were expected to show a significantly lower estimated performance IQ (PIQ), but not a lower estimated verbal IQ (VIQ), compared to light drinkers. Participants ( N = 474) were divided into four groups based on IQ and severity of alcohol use-related problems. IQ was estimated using (a short form of) the Wechsler Adult Intelligence Scale third edition. Severity of alcohol use-related problems was assessed using the Alcohol Use Disorder Identification Test. Overall, there were no significant differences between light and problematic drinkers on estimated VIQ. Within the group without MBID, estimated PIQ was significantly lower. Estimated PIQ was not lower in problematic drinkers with MBID compared to light drinkers with MBID. The results are indicative of cognitive deficits in problematic drinkers without MBID. Screening for cognitive deficits with additional instruments is advised.

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