Endostatin inhibits lymph node metastasis by a down-regulation of the vascular endothelial growth factor C expression in tumor cells

2005 ◽  
Vol 22 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Shunsuke Fukumoto ◽  
Masayo Morifuji ◽  
Yoshinori Katakura ◽  
Masamichi Ohishi ◽  
Seiji Nakamura
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Lymph Node ◽  
Growth Factor ◽  
Lymph Node Metastasis ◽  
Tumor Cells ◽  
Vascular Endothelial ◽  
Down Regulation ◽  
Node Metastasis ◽  
Factor C ◽  
Endothelial Growth Factor

Expression of GLI1 Correlates with Expression of Lymphangiogenesis Proteins, Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor Receptor 3, in Colorectal Cancer

2013 ◽  
Vol 79 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Kwang Dae Hong ◽  
Youngseok Lee ◽  
Baek-Hui Kim ◽  
Sun Il Lee ◽  
Hong Young Moon
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Lymph Node ◽  
Growth Factor ◽  
Lymph Node Metastasis ◽  
Signaling Pathway ◽  
Vascular Endothelial ◽  
Node Metastasis ◽  
Hh Signaling ◽  
Factor C ◽  
Endothelial Growth Factor

Aberrant activation of the hedgehog (Hh) signaling pathway is associated with tumorigenesis in various tissues. In colorectal cancer (CRC), evidence for Hh activation is inconsistent, and the relationship between the Hh signaling pathway and lymphangiogenesis has not been studied. The aim of this study was to determine the relationship between Hh signaling and lymphangio-genesis and the association of this relationship with lymph node metastasis in CRC. We investigated 189 patients who underwent curative surgical resection for CRC between 2002 and 2004 at Korea University Guro Hospital. Paraffin-embedded specimens of colorectal adenocarcinoma and adjacent normal mucosa were evaluated. Immunohistochemical staining for Sonic hedgehog (Shh), Gli1, vascular endothelial growth factor C (VEGFC), and VEGF receptor 3 (VEGFR3) was performed for each specimen. Tumor specimen showed significantly strong staining of Shh, Gli1, VEGFC, and VEGFR3 compared with a normal specimen. Shh expression was not associated with Gli1 expression. Gli1 expression correlated positively with VEGFC and VEGFR3 expression ( P < 0.05 in both) but not with lymph node metastasis. Activation of the Hh signaling pathway associated with Gli1 promotes expression of lymphangiogenesis proteins, VEGFC and VEGFR3, in CRC. Further studies are necessary to determine the association of this relationship with lymph node metastasis in CRC.

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