Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain

2008 ◽  
Vol 27 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Cimona V. Hinton ◽  
Shalom Avraham ◽  
Hava Karsenty Avraham
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Signaling Axis ◽  
The Brain

scholarly journals Syndecan-1 facilitates breast cancer metastasis to the brain

2019 ◽  
Author(s):  
Megan R. Sayyad ◽  
Madhavi Puchalapalli ◽  
Natasha G. Vergara ◽  
Sierra Mosticone Wangensteen ◽  
Melvin Moore ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Brain Metastasis ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Cancer Cell Migration ◽  
The Brain

AbstractPurposeAlthough survival rates for patients with localized breast cancer have increased, patients with metastatic breast cancer still have poor prognosis. Understanding key factors involved in promoting breast cancer metastasis is imperative for better treatments. In this study, we investigated the role of syndecan-1 (Sdc1) in breast cancer metastasis.MethodsTo assess the role of Sdc1 in breast cancer metastasis, we silenced Sdc1 expression in the triple-negative breast cancer human MDA-MB-231 cell line and overexpressed it in the mouse mammary carcinoma 4T1 cell line. Intracardiac injections were performed in an experimental mouse metastasis model using both cell lines. In vitro transwell blood-brain barrier (BBB) and brain section adhesion assays were utilized to specifically investigate how Sdc1 promotes brain metastasis. A cytokine array was performed to evaluate differences in the breast cancer cell secretome when Sdc1 was silenced.ResultsSilencing expression of Sdc1 in breast cancer cells significantly reduced metastasis to the brain. Conversely, overexpression of Sdc1 increased metastasis to the brain. We found that the reduction in brain metastases with Sdc1 knockdown was likely due to reduced breast cancer cell migration across the BBB and adhesion to the perivascular regions of the brain. However, there was no change in attachment to brain endothelial cells or astrocytes. Loss of Sdc1 also led to changes in breast cancer cell-secreted cytokines, which may influence the BBB.ConclusionsTaken together, our study demonstrates a role for Sdc1 in promoting breast cancer metastasis to the brain. These findings suggest that Sdc1 supports breast cancer cell migration across the BBB through regulation of cytokines, which may modulate the BBB. Further elucidating this mechanism will allow for the development of therapeutic strategies to combat brain metastasis.

Unraveling the role of CDK8 in triple-negative breast cancer metastasis

2018 ◽  
Vol 6 (Suppl. 1) ◽  
pp. A4.2
Author(s):  
Vanessa M. Knab
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Cancer Metastasis ◽  
Triple Negative ◽  
Breast Cancer Metastasis

The Role of N-Cadherin in Breast Cancer Metastasis

2002 ◽  
Author(s):  
Rachel Hazan
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

The Role of N-Cadherin in Breast Cancer Metastasis

2004 ◽  
Author(s):  
Rachel Hazan
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

Investigating the Role of Indoleamine 2,3-dioxygenase (IDO) in Breast Cancer Metastasis

2011 ◽  
Author(s):  
Courtney Smith ◽  
George Prendergast ◽  
Alexander Muller
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Indoleamine 2,3 Dioxygenase

Role of Cathepsin C During Breast Cancer Metastasis

2011 ◽  
Author(s):  
Brian Ruffell
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Cathepsin C

scholarly journals The role of von Willebrand factor in breast cancer metastasis

2021 ◽  
Vol 14 (4) ◽  
pp. 101033
Author(s):  
Chia Yin Goh ◽  
Sean Patmore ◽  
Albert Smolenski ◽  
Jane Howard ◽  
Shane Evans ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Von Willebrand Factor ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals The Role of Glycosylation in Breast Cancer Metastasis and Cancer Control

2015 ◽  
Vol 5 ◽  
Author(s):  
Alexandra C. Kölbl ◽  
Ulrich Andergassen ◽  
Udo Jeschke
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Cancer Control ◽  
Breast Cancer Metastasis

A distinct role in breast cancer for two LIV-1 family zinc transporters

2008 ◽  
Vol 36 (6) ◽  
pp. 1247-1251 ◽  
Author(s):  
Kathryn M. Taylor
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Prognostic Indicator ◽  
Breast Cancer Metastasis ◽  
Zinc Transporters ◽  
Aberrant Expression ◽  
Disease States ◽  
Cancer Spread ◽  
Protein Transporters

Zinc, essential for normal cell growth, is tightly controlled in cells by two families of zinc transporters. The aberrant expression of zinc transporters from the LIV-1 family of ZIP (Zrt/Irt-like protein) transporters is increasingly being implicated in a variety of disease states. In the present paper, I describe a mechanism for the role of ZIP7 in the progression of breast cancer, identifying it as a new target in breast cancer. Furthermore, I document a link between another zinc transporter, LIV-1, and breast cancer metastasis, identifying it as a potential new prognostic indicator of breast cancer spread.

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