scholarly journals Landscape genetics of the Tasmanian devil: implications for spread of an infectious cancer

2017 ◽  
Vol 18 (6) ◽  
pp. 1287-1297 ◽  
Author(s):  
Andrew Storfer ◽  
Brendan Epstein ◽  
Menna Jones ◽  
Steven Micheletti ◽  
Stephen F. Spear ◽  
...  
Keyword(s):  
Landscape Genetics ◽  
Tasmanian Devil ◽  
Infectious Cancer

scholarly journals CANCER INCIDENCE IN WILD ANIMALS AND THE REJECTION OF PETO’S PARADOX THEORY

2019 ◽  
Author(s):  
Sorush Niknamian
Keyword(s):  
Tasmanian Devil ◽  
Wild Animals ◽  
Long Period ◽  
Anti Cancer ◽  
Devil Facial Tumor Disease ◽  
Cancer Types ◽  
Paradox Theory ◽  
Cancer Agent ◽  
Infectious Cancer ◽  
Multicellular Organisms

Cancer affects all animals containing eukaryote cells. Less is known about the cancers that affect wild animals, since they move around and may not be easily observed for a long period of time. This review about cancers in wild animals contains useful data for the study of human cancers as well. Certain cancers in dinosaurs show that this metabolic disease is primitive and may have been around since the beginning of the multicellular organisms. This data also shows there has been some cancer types in naked mole rats and wild sharks as well. Nowadays, Tasmanian Devils are plagued by an infectious cancer known as Tasmanian devil facial tumor disease (DFTD). Since the emergence of the disease in 1996, the population has declined by more than 60 percent. This type of cancer has an allograft transmission. It seems earthworms contain an anti-cancer agent which could be of great interests in the treatment of cancer. In the discussion part of our review we have discussed how Peto’s Paradox theory of cancer is not true and we have mentioned many data of the cancer incidences in whales and elephants.

scholarly journals Cancer Incidence in Wild Animals and the Rejection of Peto’s Paradox Theory

2020 ◽  
Vol 2 (1) ◽  
pp. 1-7
Author(s):  
Sorush Niknamian ◽  
Keyword(s):  
Tasmanian Devil ◽  
Wild Animals ◽  
Long Period ◽  
Anti Cancer ◽  
Devil Facial Tumor Disease ◽  
Cancer Types ◽  
Paradox Theory ◽  
Cancer Agent ◽  
Infectious Cancer ◽  
Multicellular Organisms

Cancer affects all animals containing eukaryote cells. Less is known about the cancers that affect wild animals, since they move around and may not be easily observed for a long period of time. This review about cancers in wild animals contains useful data for the study of human cancers as well. Certain cancers in dinosaurs show that this metabolic disease is primitive and may have been around since the beginning of the multicellular organisms. This data also shows there has been some cancer types in naked mole rats and wild sharks as well. Nowadays, Tasmanian Devils are plagued by an infectious cancer known as Tasmanian devil facial tumor disease (DFTD). Since the emergence of the disease in 1996, the population has declined by more than 60 percent. This type of cancer has an allograft transmission. It seems earthworms contain an anti-cancer agent which could be of great interests in the treatment of cancer. In the discussion part of our review we have discussed how Peto’s Paradox theory of cancer is not true and we have mentioned many data of the cancer incidences in whales and

scholarly journals Lessons from the Looming Extinction of the Tasmanian Devil

2008 ◽  
Vol 14 (3) ◽  
pp. 151 ◽  
Author(s):  
D. Lunney ◽  
M. Jones ◽  
H. McCullum
Keyword(s):  
Cancer Cells ◽  
Captive Breeding ◽  
Active Management ◽  
Tasmanian Devil ◽  
Population Bottlenecks ◽  
Low Genetic Diversity ◽  
Devil Facial Tumour Disease ◽  
In The Wild ◽  
Breeding Programmes ◽  
Infectious Cancer

Extinction in the wild is now regarded as likely for the Tasmanian Devil Sarcophilus harrissi. In 1996, a disease, Devil Facial Tumour Disease (DFTD), was seen in a Devil in the wild. By mid-2008, the population had declined by about 70%, and the disease was spreading rapidly from east to west across Tasmania. DFTD is an infectious cancer, passed from one Devil to another principally, or entirely, by biting. The bite implants the cancer cells; the low genetic diversity in the Tasmanian Devil population from previous population bottlenecks or selective sweeps means that those cancer cells are not recognized by the immune system and the cancer grows in the infected Devil. Estimates of the time to extinction in the wild range from about 20 to 35 years. If, however, there are resistant genotypes within the Devil population then extinction in the wild may be averted, with numbers augmented through captive breeding programmes and active management to spread these genotypes in the wild.

Performance of partial statistics in individual-based landscape genetics

2014 ◽  
Vol 15 (3) ◽  
pp. 512-525 ◽  
Author(s):  
E. M. Kierepka ◽  
E. K. Latch
Keyword(s):  
Landscape Genetics

Quantifying 25 years of disease‐caused declines in Tasmanian devil populations: host density drives spatial pathogen spread

2021 ◽  
Vol 24 (5) ◽  
pp. 958-969
Author(s):  
Calum X. Cunningham ◽  
Sebastien Comte ◽  
Hamish McCallum ◽  
David G. Hamilton ◽  
Rodrigo Hamede ◽  
...  
Keyword(s):  
Host Density ◽  
Tasmanian Devil

scholarly journals Spatial Genetic Structure of a Symbiotic Beetle-Fungal System: Toward Multi-Taxa Integrated Landscape Genetics

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e25359 ◽  
Author(s):  
Patrick M. A. James ◽  
Dave W. Coltman ◽  
Brent W. Murray ◽  
Richard C. Hamelin ◽  
Felix A. H. Sperling
Keyword(s):  
Genetic Structure ◽  
Landscape Genetics ◽  
Spatial Genetic Structure

scholarly journals Low major histocompatibility complex diversity in the Tasmanian devil predates European settlement and may explain susceptibility to disease epidemics

2013 ◽  
Vol 9 (1) ◽  
pp. 20120900 ◽  
Author(s):  
Katrina Morris ◽  
Jeremy J. Austin ◽  
Katherine Belov
Keyword(s):  
Major Histocompatibility Complex ◽  
Tasmanian Devil ◽  
Major Histocompatibility ◽  
European Settlement ◽  
Low Genetic Diversity ◽  
Histocompatibility Complex ◽  
Devil Facial Tumour Disease ◽  
History Of ◽  
Mhc Diversity ◽  
Disease Epidemics

The Tasmanian devil ( Sarcophilus harrisii ) is at risk of extinction owing to the emergence of a contagious cancer known as devil facial tumour disease (DFTD). The emergence and spread of DFTD has been linked to low genetic diversity in the major histocompatibility complex (MHC). We examined MHC diversity in historical and ancient devils to determine whether loss of diversity is recent or predates European settlement in Australia. Our results reveal no additional diversity in historical Tasmanian samples. Mainland devils had common modern variants plus six new variants that are highly similar to existing alleles. We conclude that low MHC diversity has been a feature of devil populations since at least the Mid-Holocene and could explain their tumultuous history of population crashes.

Sign in / Sign up

Export Citation Format

Share Document