Secondary Metabolite from the Fungal Strain Monascus pilosus

Silver is a well known antimicrobial agent. It is utilized in many antimicrobial and medication. The Trichoderma and its Metabolites have also been meant for antimicrobial activity against the various bacterial and fungal strain. In the present investigation Nanoparticle of silver is prepared by chemical method, green synthesis using plants and biosynthesis using microbes. Trichoderma secondary metabolite prepared by solvent extraction method from Trichoderma harzianum which act as a capping and reducing agent. The biosynthesised silver Nanoparticles were characterized by UV-Vis spectroscopy and TEM. UV-Vis spectra of silver Nanoparticle and trichoderma extract showed absorption spectra at 420nm & 430 nm respectively while the fused nanoparticle with Trichoderma secondary metabolite showed absorption spectra at 415 nm corresponding to the surface Plasmon resonance of silver Nanoparticle. It was determined the nanoparticle showed absorption spectra at 415 nm and morphology as spherical with size range 8 to 24 nm and providing good antimicrobial activity as Trichoderma silver fused nanoparticle against many microbial strain, so it can be prepared for pharmaceutical approach against the infectious disease caused by clinical pathogenic organisms.

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SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI Chochlibus lunatus OF THE RHIZOME OF TUNJUK LANGIT (Helmynthostachys zaylanica)

Indonesian Journal of Chemistry ◽

10.22146/ijc.21275 ◽

2013 ◽

Vol 13 (3) ◽

pp. 193-198

Author(s):

Fitrya Fitrya ◽

Muharni Muharni

Keyword(s):

Secondary Metabolite ◽

Endophytic Fungi ◽

Cell Morphology ◽

Spectroscopic Technique ◽

Fungal Strain ◽

Potato Dextrose Broth ◽

Etoac Extract ◽

Isolated Compound

Helmynthostachys zaylanica which is locally known as tunjuk langit is included Ophioglosaceae genus. The rhizome of tunjuk langit is traditionally used as anticancer. Chochlibolus lunatus was isolated from the tissues of tunjuk langit rhizome. Fungal strain was identified based on the characteristics of its colony and cell morphology. Chochlibolus lunatus was cultured in Potato Dextrose Broth (PDB) medium and it was then extracted using ethylacetate (EtOAc). A secondary metabolite compound was isolated from EtOAc extract. This isolation was done by chromatography technique and the structure of this compound was determined by mean of UV, IR and NMR spectroscopic technique. Isolated compound is like oil. Based on spectra analyses, we concluded that this isolated compound was 11,12,13-trimethylheksyl-2-methylhexa-2,4-dienoat.

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Targeting secondary metabolite biosynthetic genes from the metagenome of the sponge Mycale sp

Planta Medica ◽

10.1055/s-0028-1084798 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

SA Van der Sar ◽

KM Fisch ◽

C Gurgui ◽

TA Nguyen ◽

J Piel ◽

...

Keyword(s):

Secondary Metabolite ◽

Biosynthetic Genes

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Coronilla varia L. nitrotoxins as defensive secondary metabolite against heavy metals pollution

Planta Medica ◽

10.1055/s-0031-1282948 ◽

2011 ◽

Vol 77 (12) ◽

Author(s):

M Noori ◽

F Amini ◽

M Foroghi

Keyword(s):

Heavy Metals ◽

Secondary Metabolite ◽

Metals Pollution ◽

Coronilla Varia ◽

Heavy Metals Pollution

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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES

Journal of Biomedical and Pharmaceutical Research ◽

10.32553/jbpr.v7i6.561 ◽

2018 ◽

Vol 7 (6) ◽

Author(s):

Singh Gurvinder ◽

Singh Prabhsimran ◽

Dhawan R. K.

Keyword(s):

Antimicrobial Activity ◽

Spectral Analysis ◽

Schiff Bases ◽

Antimicrobial Agents ◽

Biological Evaluation ◽

Fungal Strain ◽

Bacterial Strains ◽

Standard Drug ◽

Gram Negative ◽

E Coli

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.

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