Protective Effects of Garlic Extract, PMK-S005, Against Nonsteroidal Anti-inflammatory Drugs–Induced Acute Gastric Damage in Rats

2014 ◽  
Vol 59 (12) ◽  
pp. 2927-2934 ◽  
Author(s):  
Yoon Jeong Choi ◽  
Nayoung Kim ◽  
Ju Yup Lee ◽  
Ryoung Hee Nam ◽  
Hyun Chang ◽  
...  
Keyword(s):  
Garlic Extract ◽  
Gastric Damage ◽  
Protective Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

1990 ◽  
Vol 259 (3) ◽  
pp. G462-G467 ◽  
Author(s):  
J. L. Wallace ◽  
C. M. Keenan ◽  
D. N. Granger
Keyword(s):  
Platelet Activating Factor ◽  
Gastric Ulceration ◽  
Gastric Damage ◽  
Blue Staining ◽  
Vascular Endothelial ◽  
Cyclooxygenase Activity ◽  
Inhibit Prostaglandin Synthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Endothelial Integrity

The hypothesis that neutrophils play an important role in the pathogenesis of gastric ulceration induced by nonsteroidal anti-inflammatory drugs (NSAIDs) was tested in rats. Rats made neutropenic by prior treatment with an antibody to rat neutrophils raised in goat were found to be significantly more resistant to the gastric-damaging actions of indomethacin or naproxen than were control rats or rats pretreated with normal goat serum. The reduction of damage in neutropenic rats was not due to effects of the antineutrophil serum on either gastric acid secretion or the ability of indomethacin or naproxen to inhibit prostaglandin synthesis. Gastric cyclooxygenase activity was inhibited by greater than 95% in both normal and neutropenic rats that received indomethacin or naproxen. Reduction of circulating neutrophil numbers by treating rats with methotrexate also resulted in a significant reduction in the susceptibility to gastric damage induced by indomethacin. Since activation of circulating neutrophils appeared to be important in the development of gastric erosions after administration of indomethacin, and in the significant changes in vascular endothelial integrity (Monastral Blue staining) observed within 15 min of indomethacin administration, we investigated the possibility that leukotrienes (LTs) and platelet-activating factor (PAF) might be involved in the pathogenesis of indomethacin-induced ulceration. Changes in gastric LTB4 synthesis were not observed after indomethacin administration. Pretreatment with either an LTD4 antagonist or a PAF antagonist was without significant effect on the extent of gastric damage induced by indomethacin. These results suggest an important role for neutrophils in the pathogenesis of NSAID-induced gastric ulceration. Neutrophils may be important in the vascular injury that occurs early after administration of these compounds.

scholarly journals 988 Ethyl Pyruvate Ameliorates the Gastric Damage Induced by Nonsteroidal Anti-Inflammatory Drugs

2013 ◽  
Vol 144 (5) ◽  
pp. S-182
Author(s):  
Yuji Nadatani ◽  
Toshio Watanabe ◽  
Tetsuya Tanigawa ◽  
Shogo Takeda ◽  
Mitsue Sogawa ◽  
...  
Keyword(s):  
Ethyl Pyruvate ◽  
Gastric Damage ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Biochemical Changes of Myocardial Necrosis induced by Isoproterenol and Protective Effects of β-Blocker and Anti-inflammatory Drugs

1974 ◽  
Vol 22 (3) ◽  
pp. 669-675 ◽  
Author(s):  
TOSHIMICHI TSUBOI ◽  
KOHSAKU ISHIKAWA ◽  
YOSHIKO OHSAWA ◽  
KOUICHI YOSHIDA ◽  
MASANAO SHIMIZU
Keyword(s):  
Myocardial Necrosis ◽  
Biochemical Changes ◽  
Protective Effects ◽  
Β Blocker ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage

Stress ◽  
2014 ◽  
Vol 17 (6) ◽  
pp. 528-537 ◽  
Author(s):  
Iryna Fomenko ◽  
Alexander Sklyarov ◽  
Tetyana Bondarchuk ◽  
Lilya Biletska ◽  
Natalia Panasyuk ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Gastric Damage ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals A Review on the Effects of Melatonin on Fetal Protection during Pregnancy with Intrauterine Inflammation

2020 ◽  
Vol 24 (4) ◽  
pp. 196-203
Author(s):  
Jang Mee Kim ◽  
Ji Yeon Lee
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Animal Studies ◽  
Protective Effects ◽  
Fetal Protection ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Brain ◽  
Fetal Inflammatory Response

Intrauterine inflammation is defined as the inflammation of the chorion, amnion, and placenta. Untreated inflammation increases the risk of fetal inflammatory response syndrome, which may result in multiorgan diseases involving the brain, cardiovascular system, lung, eye, and intestine. Therefore, controlling inflammation is critical in pregnant women to reduce the risk of diseases. However, there are no safe and effective anti-inflammatory drugs for administration during pregnancy. Although the primary function of melatonin is to control circadian rhythms, it has protective effects against cellular insults occurring from hypoxia, oxidative stress, and inflammation. While animal studies support the effective and safe role of melatonin in improving pregnancy-related morbidities, it leaves plenty of opportunities for clinical studies investigating its anti-inflammatory, antioxidant, and protective effects against insults induced by intrauterine inflammation. Therefore, it will be worthwhile to investigate antenatal supplementation of melatonin in pregnant women with intrauterine inflammation to reduce the incidence of associated comorbidities.

Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review

Oral Oncology ◽  
2018 ◽  
Vol 85 ◽  
pp. 68-81 ◽  
Author(s):  
Constanza Saka Herrán ◽  
Enric Jané-Salas ◽  
Albert Estrugo Devesa ◽  
José López-López
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Protective Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats

2017 ◽  
Vol 95 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Mario I. Ortiz
Keyword(s):  
Animal Models ◽  
Clinical Management ◽  
Inflammatory Pain ◽  
Formalin Test ◽  
Mechanisms Of Action ◽  
Gastric Damage ◽  
Antinociceptive Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Anti Inflammation

Experiments using nonsteroidal anti-inflammatory drugs (NSAIDs) alone have produced limited antinociceptive effects in animal models. For this reason, the number of studies involving the administration of NSAIDs along with an adjuvant drug harboring different mechanisms of action has increased enormously. Here, combinations of diclofenac and pyrilamine were used to determine their influence on nociception (formalin test), inflammation (paw inflammation produced by carrageenan), and gastric damage in rodents. Diclofenac, pyrilamine, or combinations of diclofenac and pyrilamine produced antinociceptive and anti-inflammatory effects in the rat. The systemic administration of diclofenac alone and in combination with pyrilamine produced significant gastric damage. Effective dose (ED) values were determined for each individual drug, and isobolograms were prepared. The theoretical ED values for the antinociceptive (systemic, 35.4 mg/kg; local, 343.4 μg/paw) and the anti-inflammatory (37.9 mg/kg) effects differed significantly from the experimental ED values (systemic antinociception, 18.1 mg/kg; local antinociception, 183.3 μg/paw; anti-inflammation, 10.6 mg/kg). Therefore, it was concluded that the interactions between diclofenac and pyrilamine are synergistic. The data suggest that the diclofenac–pyrilamine combinations can interact at the systemic and local peripheral levels, thereby offering a therapeutic alternative for the clinical management of inflammatory pain.

scholarly journals The Protective Effect of Dapsone Against Ethanol, Stress, and Indomethacin-Induced Gastric Erosion in Rats

2021 ◽  
Author(s):  
Mohammad Sheibani ◽  
Sadaf Nezamoleslami ◽  
Nastaran Rahimi ◽  
Ata Abbasi ◽  
Ahmad Reza Dehpour
Keyword(s):  
Inflammatory Cytokines ◽  
Experimental Models ◽  
Gastric Damage ◽  
Male Rats ◽  
Ethanol Stress ◽  
Control Group ◽  
Gastric Erosion ◽  
Protective Effects ◽  
Gastric Erosions ◽  
Anti Inflammatory

Several factors contribute to the development of gastric erosions, including corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol, and stress. These factors can cause or worsen gastrointestinal ulcers by activating inflammatory pathways or by altering gastric mucosal blood flow. Dapsone is an antimicrobial compound with anti-inflammatory properties. The aim of this study was to evaluate the protective effects of dapsone against gastric erosions induced by alcohol, stress, or indomethacin. Gastric damage was induced in male rats in three different experimental models: ethanol (5 ml/kg, p.o.)-, water-immersion stress-, and indomethacin (30 mg/kg, p.o.)- induced ulcer. Rats in each of these three experimental models were divided into five groups: Normal group, 2. Control group (gastric damage+vehicle), 3. Gastric damage+dapsone 1 mg/kg, 4. Gastric damage+dapsone 3 mg/kg, 5. Gastric damage+dapsone 10 mg/kg. In this study, the J- score ulcer index and histopathological assessment were performed. In addition, inflammatory cytokines levels, NF-κB expression, and MPO activity were determined. Dapsone reduced the tissue injuries and erosion area in all three experimental groups compared to the control group. In addition, serum levels of inflammatory cytokines, TNF-alpha, and IL-1β were reduced in the dapsone treatment groups. The expression of NF-κB and tissue concentration of myeloperoxidase (a marker of neutrophil activation) was also reduced in rats given dapsone. To conclude, dapsone exhibits significant protective effects against the development of experimental gastric erosions in rats, and these effects seem to be related to its anti-inflammatory and antioxidant properties.

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