Soluble Dietary Fiber Can Protect the Gastrointestinal Mucosa Against Nonsteroidal Anti-Inflammatory Drugs in Mice

2016 ◽  
Vol 61 (7) ◽  
pp. 1903-1914 ◽  
Author(s):  
Hiroshi Satoh ◽  
Tetsuro Urushidani
Keyword(s):  
Dietary Fiber ◽  
Gastrointestinal Mucosa ◽  
Soluble Dietary Fiber ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Gastro-Intestinal Blood Loss during Administration of Indoprofen, Aspirin and Ibuprofen

1977 ◽  
Vol 5 (3) ◽  
pp. 155-160 ◽  
Author(s):  
G Bianchi Porro ◽  
G Corvi ◽  
L M Fuccella ◽  
G C Goldaniga ◽  
G Valzelli
Keyword(s):  
Blood Loss ◽  
Acetylsalicylic Acid ◽  
Fold Increase ◽  
Acute Effect ◽  
Gastrointestinal Mucosa ◽  
Order Of Magnitude ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Faecal Blood Loss

The acute effect of three non-steroidal anti-inflammatory drugs, ibuprofen, acetylsalicylic acid (ASA) and indoprofen, on faecal blood loss was investigated in 15 subjects by means of 51Cr-labelled erythrocytes. Ibuprofen (900 mg/day for 5 days) and indoprofen capsules and tablets (300 mg and 600 mg/day for 5 days, respectively) slightly increased the amount of blood eliminated in faeces. The increase was of the same order of magnitude for both doses of indoprofen. ASA (1,500 mg/day for 5 days) caused about a 6-fold increase in blood loss. Four days after withdrawal of ASA, faecal blood was still about twice as high as in faeces of subjects given ibuprofen and indoprofen. The method appears sensitive and reliable for comparison of the immediate effect of anti-inflammatory drugs on gastrointestinal mucosa.

Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

2009 ◽  
Vol 55 (5) ◽  
pp. 1264-1271 ◽  
Author(s):  
Hiroshi Satoh ◽  
Toshiko Hara ◽  
Daisuke Murakawa ◽  
Masashi Matsuura ◽  
Kenji Takata
Keyword(s):  
Small Intestine ◽  
Dietary Fiber ◽  
Soluble Dietary Fiber ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

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