Comprehensive Analysis of Barrett’s Esophagus: Focused on Carcinogenic Potential for Barrett’s Cancer in Japanese Patients

2020 ◽  
Author(s):  
Kentaro Ishikawa ◽  
Kenichiro Okimoto ◽  
Tomoaki Matsumura ◽  
Yosuke Hirotsu ◽  
Kenji Amemiya ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Japanese Patients ◽  
Comprehensive Analysis ◽  
Carcinogenic Potential ◽  
Barrett’S Cancer

Prospective Evaluation of the Esophageal Capsule Endoscopy for Detection of Barrett's Esophagus and Early Barrett's Cancer

2006 ◽  
Vol 63 (5) ◽  
pp. AB144
Author(s):  
Nicola Plum ◽  
Andrea May ◽  
Agnes Ipsen ◽  
Melanie Langfeld ◽  
Alexander Wree ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Capsule Endoscopy ◽  
Barrett's Esophagus ◽  
Prospective Evaluation ◽  
Barrett’S Cancer ◽  
Esophageal Capsule

Mo1210 COMPREHENSIVE ANALYSIS OF PALISADE VESSELS IN BARRETT'S ESOPHAGUS

2019 ◽  
Vol 89 (6) ◽  
pp. AB466
Author(s):  
Kentaro Ishikawa ◽  
Tomoaki Matsumura ◽  
Kenichiro Okimoto ◽  
Yushi Imai ◽  
Tsubasa Oike ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Comprehensive Analysis

scholarly journals Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mamoru Tokunaga ◽  
Kenichiro Okimoto ◽  
Naoki Akizue ◽  
Kentaro Ishikawa ◽  
Yosuke Hirotsu ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
Medical Information ◽  
Japanese Patients ◽  
Endoscopic Biopsy ◽  
University Hospital ◽  
Genetic Profile ◽  
Genetic Characteristics ◽  
Significant Difference

AbstractThe genetic characteristics of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) in the Japanese population is unclear. This study aims to investigate the genetic characteristics from nondysplastic BE (NDBE) to early EAC in Japan. Clinical information was collected. Moreover, the genetic profile of NDBE without concurrent dysplasia, early EAC, and surrounding BE were also investigated using endoscopic biopsy samples and formalin-fixed, paraffin-embedded specimens from Japanese patients by targeted next-generation sequencing. Immunohistochemical staining for p53 was also performed for EAC lesions. Targeted NGS was performed for 33 cases with 77 specimens. No significant difference exists in the NDBE group between the number of putative drivers per lesion in the short-segment Barrett’s esophagus (SSBE) and long-segment Barrett’s esophagus (LSBE) [0 (range, 0–1) vs. 0 (range, 0–1). p = 1.00]. TP53 putative drivers were found in two patients (16.7%) with nondysplastic SSBE. TP53 was the majority of putative drivers in both BE adjacent to EAC and EAC, accounting for 66.7% and 66.7%, respectively. More putative drivers per lesion were found in the EAC than in the NDBE group [1 (range, 0–3) vs. 0 (range, 0–1). p < 0.01]. The genetic variants of TP53 in the Japanese early EAC were similar to those in western countries. However, TP53 putative drivers were detected even in Japanese patients with nondysplastic SSBE. This is significant because such nondysplastic SSBE might have higher risk of progressing to high-grade dysplasia or EAC. The risks of progression may not be underestimated and appropriate follow-ups may be necessary even in patients with SSBE.Trial registration: This study was registered at the University Hospital Medical Information Network (UMIN000034247).

Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

2019 ◽  
Vol 34 (7) ◽  
pp. 1160-1165
Author(s):  
Hironobu Takedomi ◽  
Nanae Tsuruoka ◽  
Ayako Takamori ◽  
Koichi Miyahara ◽  
Kohei Yamanouchi ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Japanese Patients ◽  
Colorectal Polyps

scholarly journals Mutations of p53 in barrett's esophagus and barrett's cancer: A prospective study of ninety-eight cases

1996 ◽  
Vol 111 (2) ◽  
pp. 323-333 ◽  
Author(s):  
Paul M. Schneider ◽  
Alan G. Casson ◽  
Bernard Levin ◽  
Harinder S. Garewal ◽  
Arnulf H. Hoelscher ◽  
...  
Keyword(s):  
Prospective Study ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Barrett’S Cancer ◽  
A Prospective Study

Tu1612 Relationship Between Kyphosis and Barrett's Esophagus in Japanese Patients

2012 ◽  
Vol 75 (4) ◽  
pp. AB464 ◽  
Author(s):  
Goichi Uno ◽  
Yuji Amano ◽  
Takafumi Yuki ◽  
Akihiko Oka ◽  
Norihisa Ishimura ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Japanese Patients
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