scholarly journals Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany

Author(s):  
Christian Labenz ◽  
Karel Kostev ◽  
Leonard Kaps ◽  
Peter R. Galle ◽  
Jörn M. Schattenberg
2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Yu Zhai ◽  
Qian Xiao

Current studies have shown that sarcopenia and nonalcoholic fatty liver disease (NAFLD) have similar pathophysiological profiles. The cooccurrence of sarcopenia and NAFLD has been observed in elderly patients. The actions of these conditions are linked, and their treatments are similar. Therefore, studies should be conducted on NAFLD-sarcopenia rather than on NAFLD or sarcopenia.


2020 ◽  
Author(s):  
Panyavee Pitisuttithum ◽  
Wah Kheong Chan ◽  
Panida Piyachaturawat ◽  
Kento Imajo ◽  
Atsushi Nakajima ◽  
...  

Abstract Background: The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. non-elderly patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD); 2) identify predictors of advanced fibrosis in elderly patients with NAFLD; and 3) assess the performance of non-invasive fibrosis scores in the prediction of advance fibrosis in the elderly population. Methods: We abstracted the data of 1008 patients with NAFLD from nine centers across eight countries. Characteristics of elderly and non-elderly patients with NAFLD were compared using 1:3 sex-matched analysis. Results: Of the 1008 patients, 175 were elderly [age 64 (62-67) years], who were matched with 525 non-elderly patients [46 (36-54) years]. Elderly patients were more likely to have advanced fibrosis (35.4% vs. 13.3%; p<0.001). By multivariable analysis, factors associated with advanced fibrosis in elderly patients included female sex [odds ratio (OR) 3.21; 95% confidence interval (CI) 1.37-7.54] and hypertension (OR 3.68; 95%CI 1.11-12.23). The area under receiver-operating characteristics curve (95% CI) of aspartate aminotransferase-to-platelet ratio index, NAFLD fibrosis score and Fibrosis-4 index for predicting advanced fibrosis in elderly patients were 0.62 (0.52-0.72), 0.65 (0.55-0.75) and 0.64 (0.54-0.74) respectively. Conclusions: Elderly patients with NAFLD had a higher prevalence of advanced fibrosis than non-elderly patients. Female and hypertension were predicting factors for advanced fibrosis in the elderly. Non-invasive fibrosis scores had a lower specificity in elderly.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Panyavee Pitisuttithum ◽  
Wah Kheong Chan ◽  
Panida Piyachaturawat ◽  
Kento Imajo ◽  
Atsushi Nakajima ◽  
...  

2019 ◽  
Author(s):  
Panyavee Pitisuttithum ◽  
Wah Kheong Chan ◽  
Panida Piyachaturawat ◽  
Kento Imajo ◽  
Atsushi Nakajima ◽  
...  

Abstract Background and Aim The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. non-elderly patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD); 2) identify predictors of advanced fibrosis in elderly patients with NAFLD; and 3) assess the performance of non-invasive fibrosis scores in the prediction of advance fibrosis in the elderly population. Methods We abstracted the data of 1008 patients with NAFLD from nine centers across eight countries. Characteristics of elderly and non-elderly patients with NAFLD were compared using 1:3 sex-matched analysis. Results Of the 1008 patients, 175 were elderly (age 65±4 years), who were matched with 525 non-elderly patients (44±11 years). Elderly patients were more likely to have advanced fibrosis (35.4% vs. 13.3%; p<0.001). By multivariable analysis, factors associated with advanced fibrosis in elderly patients included female sex (odds ratio [OR] 3.21; 95% confidence interval [CI] 1.37-7.54) and hypertension (OR 3.68; 95%CI 1.11-12.23). The area under receiver-operating characteristics curve (95% CI) of aspartate aminotransferase-to-platelet ratio index, NAFLD fibrosis score and Fibrosis-4 index for predicting advanced fibrosis in elderly patients were 0.62 (0.52-0.72), 0.65 (0.55-0.75) and 0.64 (0.54-0.74) respectively. Conclusions Elderly patients with NAFLD had a higher prevalence of advanced fibrosis than non-elderly patients. Female and hypertension were predicting factors for advanced fibrosis in the elderly. Non-invasive fibrosis scores had a lower specificity in elderly.


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