scholarly journals Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention

2013 ◽  
Vol 12 (2) ◽  
pp. 273-277 ◽  
Author(s):  
Karen H. Lu ◽  
Molly Daniels
Keyword(s):  
Ovarian Cancer ◽  
Lynch Syndrome ◽  
Screening And Prevention

scholarly journals Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 925
Author(s):  
Vasiliki Baroutsou ◽  
Meghan L. Underhill-Blazey ◽  
Christian Appenzeller-Herzog ◽  
Maria C. Katapodi
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Genetic Testing ◽  
Lynch Syndrome ◽  
Family Communication ◽  
Meta Analysis ◽  
Decision Aids ◽  
Cancer Predisposition ◽  
Cascade Screening ◽  
Screening And Prevention

Evidence-based guidelines recommend cascade genetic testing of blood relatives of known Hereditary Breast and Ovarian Cancer (HBOC) or Lynch Syndrome (LS) cases, to inform individualized cancer screening and prevention plans. The study identified interventions designed to facilitate family communication of genetic testing results and/or cancer predisposition cascade genetic testing for HBOC and LS. We conducted a systematic review and meta-analysis of randomized trials that assessed intervention efficacy for these two outcomes. Additional outcomes were also recorded and synthesized when possible. Fourteen articles met the inclusion criteria and were included in the narrative synthesis and 13 in the meta-analysis. Lack of participant blinding was the most common risk of bias. Interventions targeted HBOC (n = 5); both HBOC and LS (n = 4); LS (n = 3); or ovarian cancer (n = 2). All protocols (n = 14) included a psychoeducational and/or counseling component. Additional components were decision aids (n = 4), building communication skills (n = 4), or motivational interviewing (n = 1). The overall effect size for family communication was small (g = 0.085) and not significant (p = 0.344), while for cascade testing, it was small (g = 0.169) but significant (p = 0.014). Interventions show promise for improving cancer predisposition cascade genetic testing for HBOC and LS. Future studies should employ family-based approaches and include racially diverse samples.

scholarly journals Characteristics of Lynch syndrome associated ovarian cancer

2018 ◽  
Vol 150 (2) ◽  
pp. 324-330 ◽  
Author(s):  
J.M. Woolderink ◽  
G.H. De Bock ◽  
J.A. de Hullu ◽  
H. Hollema ◽  
R.P. Zweemer ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lynch Syndrome

European/U.S. Comparison and Contrasts in Ovarian Cancer Screening and Prevention in a High-Risk Population

2017 ◽  
pp. 124-127
Author(s):  
Marian J. Mourits ◽  
G. H. de Bock
Keyword(s):  
United States ◽  
Ovarian Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
The United States ◽  
High Risk Population ◽  
Genome Wide Association Studies ◽  
Hereditary Ovarian Cancer ◽  
Ovarian Cancer Screening ◽  
Screening And Prevention

The history of screening and prevention of ovarian cancer among high-risk women in the United States and Europe is one of mutual inspiration, with researchers learning from each others’ findings and insights and collaborating with investigators from both sides of the Atlantic ocean. Examples of simultaneous and joint development of knowledge and scientific points of view include the paradigm shift from ovarian to fallopian tube high-grade serous cancer and the cessation of simultaneous adoption of ovarian cancer screening by clinicians in both the United States and Europe. Examples of joint efforts with fruitful results include international collaboration in large population-based, genome-wide association studies and in epidemiologic database studies. Research in the field of hereditary ovarian cancer is a great example of mutual inspiration and joint efforts for the purpose of improving knowledge and health care for women with hereditary ovarian cancer.

scholarly journals PMS2 germline mutation c.943C>T (p.Arg315*)‐induced Lynch syndrome‐associated ovarian cancer

2019 ◽  
Vol 7 (6) ◽  
Author(s):  
Xiaoqing Guo ◽  
Weimin Wu ◽  
Hao Gao ◽  
Xiaofeng Li ◽  
Qizhi He ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lynch Syndrome ◽  
Germline Mutation
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