On the Genesis of the Idiotypic Network Theory

2012 ◽  
Vol 46 (1) ◽  
pp. 125-158 ◽  
Author(s):  
Andrea Civello
2004 ◽  
Vol 11 (3-4) ◽  
pp. 281-285 ◽  
Author(s):  
Ljiljana Dimitrijevic ◽  
Snezana Živanevic-Simonovic ◽  
Marijana Stojanovic ◽  
Aleksandra Inic-Kanada ◽  
Irena Živkovic

In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens.The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Abs1 and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system have inspired us in our attempt at explaining the possible role of natural Id in immune memory.


Author(s):  
Muhammad Tahir Khan ◽  
Toar Imanuel ◽  
Yelnil Gabo ◽  
C. W. de Silva

The human immune system is a network of cells, tissues, and other organs that defend the body against foreign invaders called antigens. Jerne’s Idiotypic network theory concerns how an antibody in the immune system stimulates or suppresses another antibody and recognizes an antigen. Based on the principles of the human immune system and Jerne’s idiotypic network theory this paper presents a method for cooperation among robots in a multi-robot system. The developed cooperative multi-robot system is fully autonomous and distributed. In the present paper, cooperation is not assumed a priori. If a robot is unable to complete a task alone, the system autonomously chooses the appropriate number of suitable and most capable robots in the fleet to cooperate with each other in carrying out a global task. The approach developed in the paper incorporates robustness and fault tolerance in immune system–based multi-robot cooperation.


Author(s):  
Huda Ibrahim ◽  
Hasmiah Kasimin

An effi cient and effective information technology transfer from developed countries to Malaysia is an important issue as a prerequisite to support the ICT needs of the country to become not only a ICT user but also a ICT producer. One of the factors that infl uences successful information technology transfer is managing the process of how technology transfer occurs in one environment. It involves managing interaction between all parties concerned which requires an organized strategy and action toward accomplishing technology transfer objective in an integrated and effective mode. Using a conceptual framework based on the Actor Network Theory (ANT), this paper will analyse a successful information technology transfer process at a private company which is also a supplier of information technology (IT) products to the local market. This framework will explain how the company has come up with a successful technology transfer in a local environment. Our study shows that the company had given interest to its relationships with all the parties involved in the transfer process. The technology transfer programme and the strategy formulated take into account the characteristics of technology and all those involved.  


2014 ◽  
Vol 1 (1) ◽  
pp. 47-56
Author(s):  
Milan Palat

Bu çalışmanın amacı, Türkiye’den göç ve Almanya’nın ekonomik göstergeleri arasındaki ilişkiyi, nicel metot yöntemleri kullanarak değerlendirmektir. Türkiye’nin belirsiz Avrupa ile bütünleşme beklentilerine rağmen  Avrupa Birliğinin köklü üyelerine olan Türk göçü devam edecektir. Çok sayıda Türk azınlığın yaşadığı ve hayat standartlarının yüksek olduğu Almanya, Hollanda ve Fransa’ya  büyük bir göç dalgası gerçekleşebilir. Çalışmanın istatistiksel bölümünün sonuçları, toplam göç ile gayri safi yurtiçi hasıladaki büyüme arasında pozitif, toplam göç ile işsizlik arasındaki negatif ve tahmin edilen bağımlılık yönüyle uygunluk içerisinde olan toplam göç ile aylık gelir arasında pozitif ilişki olduğunu göstermektedir. Türkiye’den göçle işsizlik arasındaki ilişki, toplam göçle olan ilişkiden daha düşüktür. Ancak, Almanya’daki yabancı mevcudiyeti ile Türkiye’den göç arasında bir ilişki bulunmaktadır. Bu durum, var olan göçmen topluluğunun olduğu yerin, yeni göçmenleri, köken bağlarına dayanarak cezbetmesi ve maliyet- riskler sebebiyle göçün düşük seviye de olduğuna dayanan kuramsal Ağ teorisi görüşü ile uygunluk göstermektedir. Göç ve işsizlik arasında gözlenen ilişki, Almanya’ya göçün  işgücü piyasasında talepte meydana gelen değişime karşılık geldiği gerçeğini göstermektedir. İşsizlik ve göç olgularının meydana geliş zamanlarında bir aralık  olsa bile  göç, Alman emek pazarında var olan dengesizliklerin azaltılmasında nispeten etkili bir mekanizma gibi görünmektedir. ENGLISH TITLE & ABSTRACTTurkish Immigration to the European Union: The Case of GermanyThe objective of the paper was to evaluate the relationships between immigration from Turkey and economic indicators in Germany using  quantitative methods. Despite Turkey’s unclear European integration prospects, it is predicted that Turkish immigration to  established member countries of the EU will continue. The strongest waves may flow to Germany, Netherlands or France, where numerous Turkish minorities are already present and where the living standards are high. Results from the statistical analysis of the paper showed a positive correlation between immigration total and the growth of gross domestic product. On the other hand, a negative correlation of immigration total and unemployment was found and a positive relationship between immigration total and income total which is in agreement with the expected dependency direction. With regards to  immigration from Turkey it is less correlated to unemployment than immigration total. But there is a correlation between immigration from Turkey and the stock of foreigners in Germany This is in accordance with the theoretical concept of network theory where an existing community of migrants keeps attracting new migrants because the costs and risks associated with migration are lower, thanks to established linkages to the country of origin. The observed correlation of migration and unemployment points to the fact that immigration to Germany responds to changes in demand in the labour market. Even though a time lag may occur in the case of unemployment and immigration, migration appears to be a relatively effective mechanism to offset existing imbalances in German labour markets. 


2017 ◽  
Vol 23 (2) ◽  
pp. 100-121
Author(s):  
Michel Chambon

This article explores the ways in which Christians are building churches in contemporary Nanping, China. At first glance, their architectural style appears simply neo-Gothic, but these buildings indeed enact a rich web of significances that acts upon local Christians and beyond. Building on Actor-Network Theory and exploring the multiple ties in which they are embedded, I argue that these buildings are agents acting in their own right, which take an active part in the process of making the presence of the Christian God tangible.


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