Thymosin β4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation

Inflammation ◽  
2021 ◽  
Author(s):  
Zhen Tian ◽  
Naijuan Yao ◽  
Fei Wang ◽  
Litao Ruan
Keyword(s):  
Lung Fibrosis ◽  
Oxidative Injury ◽  
Thymosin Β4 ◽  
Murine Lung

Silica induced Expression of IL-1beta, IL-6, TNF-beta, TGF-alpha, in the Experimental Murine Lung Fibrosis

1998 ◽  
Vol 45 (4) ◽  
pp. 835 ◽  
Author(s):  
Shin Young Ki ◽  
Sung Woo Park ◽  
Myung Ran Lee ◽  
Eun Young Kim ◽  
Soo Taek Uh ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Induced Expression ◽  
Murine Lung

scholarly journals Simvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis

2017 ◽  
Vol 8 (6) ◽  
pp. e2860-e2860 ◽  
Author(s):  
Ye-JI Lee ◽  
Meung-Joo Kim ◽  
Young-So Yoon ◽  
Youn-Hee Choi ◽  
Hee-Sun Kim ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Apoptotic Cell ◽  
Simvastatin Treatment ◽  
Murine Lung

Protective effects of thymosin β4 in a mouse model of lung fibrosis

2012 ◽  
Vol 1269 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Enrico Conte ◽  
Tiziana Genovese ◽  
Elisa Gili ◽  
Emanuela Esposito ◽  
Maria Iemmolo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lung Fibrosis ◽  
Protective Effects ◽  
Thymosin Β4

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Science ◽  
2019 ◽  
Vol 363 (6432) ◽  
pp. eaau0964 ◽  
Author(s):  
Svetoslav Chakarov ◽  
Hwee Ying Lim ◽  
Leonard Tan ◽  
Sheau Yng Lim ◽  
Peter See ◽  
...  
Keyword(s):  
Gene Expression ◽  
Functional Programming ◽  
Lung Fibrosis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Tissue Homeostasis ◽  
Murine Lung ◽  
Macrophage Depletion ◽  
Heterogeneous Cell Population ◽  
Macrophage Populations

Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined. Here we studied IMs from murine lung, fat, heart, and dermis. We identified two independent IM subpopulations that are conserved across tissues: Lyve1loMHCIIhiCX3CR1hi (Lyve1loMHCIIhi) and Lyve1hiMHCIIloCX3CR1lo (Lyve1hiMHCIIlo) monocyte-derived IMs, with distinct gene expression profiles, phenotypes, functions, and localizations. Using a new mouse model of inducible macrophage depletion (Slco2b1flox/DTR), we found that the absence of Lyve1hiMHCIIlo IMs exacerbated experimental lung fibrosis. Thus, we demonstrate that two independent populations of IMs coexist across tissues and exhibit conserved niche-dependent functional programming.

Anti-fibrotic effect of meloxicam in a murine lung fibrosis model

2007 ◽  
Vol 564 (1-3) ◽  
pp. 181-189 ◽  
Author(s):  
Hossam M.M. Arafa ◽  
Mohamed H. Abdel-Wahab ◽  
Mohamed F. El-Shafeey ◽  
Osama A. Badary ◽  
Farid M.A. Hamada
Keyword(s):  
Lung Fibrosis ◽  
Murine Lung

Interleukin (IL)-6 And IL-11 Depletion Attenuates Bleomycin-Induced Murine Lung Fibrosis

2011 ◽  
Author(s):  
Hui Ling Lau ◽  
Robert J.J. O'Donoghue ◽  
Gary P. Anderson ◽  
Jessica Jones ◽  
Cecilia M. Prele ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Murine Lung

scholarly journals Therapeutic Efficacy of Cintredekin Besudotox (IL13-PE38QQR) in Murine Lung Fibrosis Is Unaffected by Immunity to Pseudomonas aeruginosa Exotoxin A

PLoS ONE ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. e8721 ◽  
Author(s):  
Rogério S. Rosada ◽  
Ana P. Moreira ◽  
Fabiani G. Frantz ◽  
Raj K. Puri ◽  
Aquilur Rahman ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Therapeutic Efficacy ◽  
Lung Fibrosis ◽  
Exotoxin A ◽  
Murine Lung ◽  
Pseudomonas Aeruginosa Exotoxin

Ammonia aggravates emotional stress-induced gastric mucosal oxidative injury through the cancellation of heat shock protein 70 (HSP70)

2001 ◽  
Vol 120 (5) ◽  
pp. A152-A152
Author(s):  
H SUZUKI ◽  
S NAGAHASHI ◽  
M MIYAZAWA ◽  
M MORI ◽  
H NAGATA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Emotional Stress ◽  
Heat Shock Protein 70 ◽  
Oxidative Injury
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