— Pseudomembranous trigonitis is a syndrome characterized by urgency, frequency, dysuria, bearing down and dyspareunia, with a typical endoscopic appearance and repeatedly negative urine culture examinations. Cystoscopically it appears as a white patch on the mucosal surface, usually well demarcated and often irregular in shape. The lesion may be finely granular in appearance and extend upward toward the ureteral orifices. Histologically it is a squamous not keratinizing metaplasia. Fifty-four female patients were treated with Nd:YAG laser photocoagulation at our Urologic Department from January 1994 to June 1995. Cystoscopic follow-up showed uniform riepithelization, with linear healing, undoubtedly contributing to the relief of symptoms. In our experience, laser treatment gave good and lasting relief of symptoms like no other therapies; so, high patient compliance, easy technique and good results make Nd:YAG laser photocoagulation highly effective in PMT management.