Sensitivity of laser flare photometry compared to slit-lamp cell evaluation in monitoring anterior chamber inflammation in uveitis

Background: To evaluate effect of maximal anterior cortical lens density, iris scatter and anterior chamber depth on laser flare photometry. Methods: Patients diagnosed with clinical uveitis were enrolled in the study. Clinical flare gradings were recorded upon the Standardization of Uveitis Nomenclature. Aqueous flare was measured with an automated device (Kowa FM-700). Back-scattering from anterior cortical lens and anterior iris surface was calculated from Scheimpflug images. A curvilinear regression model was used to calculate estimated values for each clinical grade. These values were used to split cases in Group I (laser flare photometry lower than estimated) and Group II (laser flare photometry higher than estimated). Mean anterior chamber depth, pupil aperture, maximal anterior cortical lens density and iris scatter values were compared between two groups. A stepwise multiple regression analysis was performed to determine the effect of clinical flare gradings and ocular parameters on aqueous flare measurements. Results: The study included 228 eyes of 114 cases. Scheimpflug images were obtained from 105 eyes. Estimated aqueous flare measurements (in photons/milliseconds) were 4.87, 8.50, 14.81, 25.83, 45.04 and 136.93 for 0, 0.5+, 1+, 1.5+, 2+ and 3+ clinical flare respectively. Group II had higher maximal anterior cortical lens density than Group I (96.6 ± 37.1 vs 77.9 ± 17.1 pixel unit, p = 0.001). The measured aqueous flare was significantly related to clinical flare, maximal anterior cortical lens density and pupil aperture (adjusted R2: 0.480, p < 0.001). Conclusion: The back-scattered light from anterior cortical lens could affect laser flare photometry measurements. This effect might be quantified by Scheimpflug imaging.

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A Recurrent Central Band Keratopathy in a Child

The Journal of Rheumatology ◽

10.3899/jrheum.200462 ◽

2021 ◽

pp. jrheum.200462

Author(s):

Séverine Guillaume-Czitrom ◽

Sophie Stephan ◽

Bahram Bodaghi

Keyword(s):

Anterior Uveitis ◽

Treatment Choice ◽

Simultaneous Occurrence ◽

C3 Glomerulopathy ◽

Slit Lamp ◽

Laser Flare Photometry ◽

Band Keratopathy ◽

Laser Flare ◽

First Time

For the first time, to our knowledge, we present the case of a child with simultaneous occurrence of a C3-glomerulopathy and an anterior uveitis complicated with severe band keratopathy (BK). In addition, repeated evaluations of uveitis disclosed important differences between slit lamp and laser flare photometry (LFP) results due to BK, making treatment choice difficult.

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Restraining Inflammation in Pseudoexfoliation Syndrome

US Ophthalmic Review ◽

10.17925/usor.2017.10.01.19 ◽

2017 ◽

Vol 10 (01) ◽

pp. 19

Author(s):

Marco Coassin ◽

Luigi Fontana ◽

◽

Keyword(s):

Optical Coherence Tomography ◽

Cataract Surgery ◽

Anterior Chamber ◽

Ophthalmic Solution ◽

Macular Thickness ◽

Pseudoexfoliation Syndrome ◽

Optical Coherence ◽

Laser Flare Photometry ◽

Postoperative Inflammation ◽

Laser Flare

Patients with pseudoexfoliation syndrome (PEX) experience more intense inflammation after phacoemulsification compared to routine cataracts. The effect of topical nonsteroidal anti-inflammatories (NSAIDs) in eyes with PEX have not been studied to date. Laser flare photometry was used in this study to evaluate subtle amounts of postoperative inflammation. The addition of bromfenac to dexamethasone ophthalmic solution significantly reduced anterior chamber inflammation after cataract surgery in PEX when compared to dexamethasone alone. Postoperative macular thickness at optical coherence tomography (OCT) was also positively affected by the addition of topical bromfenac.

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Rabbit Intraocular Reactivity to Endotoxin Measured by Slit-Lamp Biomicroscopy and Laser Flare Photometry

Ophthalmology ◽

10.1016/j.ophtha.2012.04.004 ◽

2012 ◽

Vol 119 (7) ◽

pp. e19-e23 ◽

Cited By ~ 11

Author(s):

Robert B. Nussenblatt ◽

Don Calogero ◽

Shelley Y. Buchen ◽

Henry A. Leder ◽

Margot Goodkin ◽

...

Keyword(s):

Slit Lamp ◽

Laser Flare Photometry ◽

Laser Flare ◽

Slit Lamp Biomicroscopy

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Correlation between anterior chamber characteristics and laser flare photometry immediately after femtosecond laser treatment before phacoemulsification

Eye ◽

10.1038/eye.2016.110 ◽

2016 ◽

Vol 30 (8) ◽

pp. 1110-1117 ◽

Cited By ~ 6

Author(s):

M Pahlitzsch ◽

N Torun ◽

M L Pahlitzsch ◽

M K J Klamann ◽

J Gonnermann ◽

...

Keyword(s):

Femtosecond Laser ◽

Anterior Chamber ◽

Laser Treatment ◽

Laser Flare Photometry ◽

Laser Flare

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Comparative Analysis of Anterior Chamber Flare Grading between Clinicians with Different Levels of Experience and Semi-automated Laser Flare Photometry

Ocular Immunology and Inflammation ◽

10.3109/09273948.2014.990042 ◽

2014 ◽

pp. 1-10 ◽

Cited By ~ 9

Author(s):

Rupesh Agrawal ◽

Pearse A. Keane ◽

Jasmin Singh ◽

Zubin Saihan ◽

Andreas Kontos ◽

...

Keyword(s):

Comparative Analysis ◽

Anterior Chamber ◽

Laser Flare Photometry ◽

Laser Flare ◽

Different Levels ◽

Anterior Chamber Flare

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Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis

European Journal of Ophthalmology ◽

10.1177/1120672119892804 ◽

2019 ◽

Vol 30 (6) ◽

pp. 1390-1396

Author(s):

Elisabetta Miserocchi ◽

Chiara Giuffrè ◽

Maria Vittoria Cicinelli ◽

Alessandro Marchese ◽

Maurizio Gattinara ◽

...

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Anterior Chamber ◽

Inflammatory Activity ◽

Low Grade ◽

Complete Disappearance ◽

Slit Lamp ◽

Slit Lamp Examination ◽

Laser Flare ◽

Anterior Chamber Flare ◽

Laser Flare Meter

Purpose: To evaluate the efficacy and the safety of curcumin-phosphatidylcholine complex in children affected by juvenile idiopathic arthritis–associated uveitis as an adjunctive treatment to chronic systemic immunosuppressive therapy. Methods: In this retrospective, longitudinal study, we treated patients affected by juvenile idiopathic arthritis–associated uveitis with residual low-grade inflammatory activity in the anterior chamber with one tablet of curcumin-phosphatidylcholine complex per day, over a year. Low-grade inflammatory activity was characterized by flare 1+ at slit-lamp examination and 10–50 photon counts per ms) at the FC500 laser flare meter. Inactivity of uveitis was defined as complete disappearance of flare at the slit-lamp examination and values <10 ph/ms at laser flare meter. Conversely, recurrence of the uveitis was defined as a one-step increase from baseline in anterior chamber cells levels or laser flare meter measurements >50 ph/ms. Results: A total of 22 out of 27 patients (81%) achieved inactivity at the end of the study. Five patients (19%) did not show a significant reduction in anterior chamber flare, remaining stable throughout the follow-up. Only three episodes of flare-ups in three different patients were recorded. Overall, the treatment was well tolerated by all patients and no ocular discomfort, ocular side effects, or allergic reactions were registered. Conclusion: Adjunctive therapy with curcumin in patients affected by juvenile idiopathic arthritis–associated uveitis improves mild chronic anterior chamber flare and presents a good safety profile. Despite being mild, anterior chamber inflammation should be minimized to avoid the development of sight-threatening complications in these patients.

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