Data quality in drug discovery: the role of analytical performance in ligand binding assays

Flow cytometer is a powerful cellular analysis tool consists of three main components; fluidics, optics and electronics. Flow cytometry methods have been used in all stages of drug development as like ligand binding assays (LBA). Both LBA and flow cytometry methods require specific interaction between the critical reagents and the analytes. Antibodies and their conjugates, viable dyes and permeabilizing buffer are the main critical reagents in flow cytometry methods. Similarly, antibodies, engineered proteins and their conjugates are the main critical reagents in LBA. The main difference between the two methods is the lack of true reference standards for flow cytometry cellular analysis.

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Strategies to minimize variability and bias associated with manual pipetting in ligand binding assays to assure data quality of protein therapeutic quantification

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2010.04.025 ◽

2010 ◽

Vol 53 (3) ◽

pp. 623-630 ◽

Cited By ~ 26

Author(s):

Kinnari Pandya ◽

Chad A. Ray ◽

Laura Brunner ◽

Jin Wang ◽

Jean W. Lee ◽

...

Keyword(s):

Ligand Binding ◽

Data Quality ◽

Binding Assays ◽

Protein Therapeutic

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Mass Ligand-Binding Screening Strategies for Identification of Leads for New Drug Discovery

PsycEXTRA Dataset ◽

10.1037/e495942006-003 ◽

1993 ◽

Author(s):

Ronald M. Burch ◽

Keyword(s):

Drug Discovery ◽

Ligand Binding ◽

New Drug ◽

Screening Strategies

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The Role of Technological Change in the Long-run Global Economy Forecasting

Voprosy Ekonomiki ◽

10.32609/0042-8736-2013-1-97-116 ◽

2013 ◽

pp. 97-116 ◽

Cited By ~ 1

Author(s):

A. Apokin

Keyword(s):

Technological Change ◽

Data Quality ◽

Long Range ◽

Global Economy ◽

World Economy ◽

Qualitative Approaches ◽

Long Run ◽

The World ◽

National Economies

The author compares several quantitative and qualitative approaches to forecasting to find appropriate methods to incorporate technological change in long-range forecasts of the world economy. A?number of long-run forecasts (with horizons over 10 years) for the world economy and national economies is reviewed to outline advantages and drawbacks for different ways to account for technological change. Various approaches based on their sensitivity to data quality and robustness to model misspecifications are compared and recommendations are offered on the choice of appropriate technique in long-run forecasts of the world economy in the presence of technological change.

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