The industrial IoT marching towards the digital twin and the broad spectrum of applications need the specialized low power protocols for communication and data transfer. This chapter provides a comprehensive discussion on the challenges, opportunities, use cases, platforms, and protocols for the deployment of low power protocols in the context of IoT applications. Moreover, discussion extends to the various custom techniques for energy saving in the communication of sensors to hardware, hardware to Cloud, and deferred data pushing in edge computing. The traditional wireless data transfer and communication protocols are suitable in case of the hardware platforms connected with seamless power supply. However, there is need of low power protocols 6LoWPAN, LoRaWAN, Sub 1, ZigBee, BLE, NFC, and other telecommunication protocols across several IoT applications. The SBCs and micro-controllers are not always equipped with these protocol-enabled hardware. This chapter addresses the suitable hardware and combination with low energy options as per the budget, range, and specifications.