Novel chitosan hydrogel formed by ethylene glycol chitosan, 1,6-diisocyanatohexan and polyethylene glycol-400 for tissue engineering scaffold: in vitro and in vivo evaluation

2014 ◽  
Vol 25 (8) ◽  
pp. 1903-1913 ◽  
Author(s):  
Zhu Chen ◽  
Ming Zhao ◽  
Kang Liu ◽  
Yuqing Wan ◽  
Xudong Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polyethylene Glycol ◽  
Ethylene Glycol ◽  
Tissue Engineering Scaffold ◽  
Glycol Chitosan ◽  
In Vivo Evaluation ◽  
Polyethylene Glycol 400 ◽  
Chitosan Hydrogel

scholarly journals Nanogels of Succinylated Glycol Chitosan-Succinyl Prednisolone Conjugate: Preparation, In Vitro Characteristics and Therapeutic Potential

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 333 ◽  
Author(s):  
Zhou ◽  
Ichikawa ◽  
Ikeuchi-Takahashi ◽  
Hattori ◽  
Onishi
Keyword(s):  
Therapeutic Potential ◽  
Trinitrobenzene Sulfonic Acid ◽  
Glycol Chitosan ◽  
In Vivo Evaluation ◽  
Drug Effectiveness ◽  
Thymus Atrophy ◽  
Negative Surface ◽  
Negative Surface Charge

A novel anionic nanogel system was prepared using succinylated glycol chitosan-succinyl prednisolone conjugate (S-GCh-SP). The nanogel, named NG(S), was evaluated in vitro and in vivo. S-GCh-SP formed a nanogel via the aggregation of hydrophobic prednisolone (PD) moieties and the introduced succinyl groups contributed to the negative surface charge of the nanogel. The resultant NG(S) had a PD content of 13.7% (w/w), was ca. 400 nm in size and had a -potential of −28 mV. NG(S) released PD very slowly at gastric pH and faster but gradually at small intestinal pH. Although NG(S) was easily taken up by the macrophage-like cell line Raw 264.7, it did not decrease cell viability, suggesting that the toxicity of the nanogel was very low. The in vivo evaluation was performed using rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. NG(S) and PD alone were not very effective at 5 mg PD eq./kg. However, NG(S) at 10 mg PD eq./kg markedly suppressed colonic damage, whereas PD alone did not. Furthermore, thymus atrophy was less with NG(S) than with PD alone. These results demonstrated that NG(S) is very safe, promotes drug effectiveness and has low toxicity. NG(S) has potential as a drug delivery system for the treatment of ulcerative colitis.

scholarly journals Retraction of “Flexible and Microporous Chitosan Hydrogel/Nano ZnO Composite Bandages for Wound Dressing: In Vitro and In Vivo Evaluation”

2019 ◽  
Vol 11 (31) ◽  
pp. 28596-28596 ◽  
Author(s):  
P. T. Sudheesh Kumar ◽  
Vinoth-Kumar Lakshmanan ◽  
T.V. Anilkumar ◽  
C. Ramya ◽  
P. Reshmi ◽  
...  
Keyword(s):  
Wound Dressing ◽  
In Vivo Evaluation ◽  
Chitosan Hydrogel ◽  
Nano Zno

scholarly journals Gellan Gum Injectable Hydrogels for Cartilage Tissue Engineering Applications: In Vitro Studies and Preliminary In Vivo Evaluation

2010 ◽  
Vol 16 (1) ◽  
pp. 343-353 ◽  
Author(s):  
João T. Oliveira ◽  
Tírcia C. Santos ◽  
Luís Martins ◽  
Ricardo Picciochi ◽  
Alexandra P. Marques ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Gellan Gum ◽  
In Vitro Studies ◽  
Cartilage Tissue ◽  
Engineering Applications ◽  
In Vivo Evaluation ◽  
Injectable Hydrogels

In vitro and in vivo evaluation of the marine sponge skeleton as a bone mimicking biomaterial

2015 ◽  
Vol 7 (2) ◽  
pp. 250-262 ◽  
Author(s):  
Samit K. Nandi ◽  
Biswanath Kundu ◽  
Arnab Mahato ◽  
Narsinh L. Thakur ◽  
Siddhartha N. Joardar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Marine Sponge ◽  
Marine Sponges ◽  
In Vivo Evaluation

This investigation was carried out to identify and characterize marine sponges as potential bioscaffolds in bone tissue engineering.

scholarly journals In Vitro and In Vivo Evaluation of a 64Cu-Labeled Polyethylene Glycol-Bombesin Conjugate

2004 ◽  
Vol 19 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Buck E. Rogers ◽  
Debbie Della Manna ◽  
Ahmad Safavy
Keyword(s):  
Polyethylene Glycol ◽  
In Vivo Evaluation
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