Protective effect of ethanolic extract of Terminalia arjuna bark against ethylene glycol induced urolithiasis in male rats: In-vitro and In-Vivo evaluation

2020 ◽  
Vol 13 (12) ◽  
pp. 6132-6139
Author(s):  
Anshuman Rai ◽  
Anamika Gautam ◽  
Sakshi Panchal ◽  
Ankita Sood ◽  
Pankaj Prashar ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protective Effect ◽  
Ethanolic Extract ◽  
Male Rats ◽  
Terminalia Arjuna ◽  
In Vivo Evaluation

scholarly journals In vitro and In vivo Evaluation of Potential Anti Diabetic Efficacy On Cassia Auriculata Flowers

2018 ◽  
Vol 11 (4) ◽  
pp. 2043-2050
Author(s):  
G. Nagarajaperumal ◽  
V.E. Idachristi ◽  
M. Karpakavalli ◽  
S. Mohan
Keyword(s):  
Digestive Enzyme ◽  
Ethanolic Extract ◽  
Inhibition Mechanism ◽  
Phytochemical Analysis ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Cassia Auriculata ◽  
Study Results

Diabetes mellitus (DM) is most significant health problem in various developed and developing countries due to alteration of various clinical and pathological factors. Current work was intended for examine in vitro and in vivo anti diabetic competence of Cassia Auriculata flowers and its phytochemical analysis. The inhibitory effects on carbohydrate digestive enzyme α- amylase interaction with various extracts of Cassia Auriculata were contrast with acarbose. Hypoglycemic activity was executed with standard as a glibenclamide. Study indicated ethanolic extract showed higher action on α- amylase inhibition with assessment of IC50 value; 43.6%. Based on the above results of in vitro studies were used to selected ethanolic extract of Cassia Auriculata flower used for further study. Results of animal studies indicated that the ethanolic extract of C. Auriculata has shown dose dependent action (200 mg/ kg (1.20±0.91↓) and 400 mg / kg (4 ± 0.01↓) when compared to control and standard drug treated groups. Our study confirmed to ethanolic extract work through the α- amylase inhibition mechanism. Our view bioactive constituents confirm anti diabetic capacity and afford methodical source for validation of Cassia Auriculata flowers in ayurvedic formulations on diminution of DM prevalence.

scholarly journals Influence of Poly(Ethylene Glycol) End Groups on Poly(Ethylene Glycol)-Albumin System Properties as a Potential Degradable Tissue Scaffold

2018 ◽  
Vol 10 (1) ◽  
pp. 1 ◽  
Author(s):  
Robyn Overby ◽  
Dale Feldman
Keyword(s):  
Ethylene Glycol ◽  
Crosslinking Agent ◽  
Poly Ethylene Glycol ◽  
In Vivo Evaluation ◽  
Tissue Scaffold ◽  
Handling Characteristics ◽  
Poly Ethylene ◽  
The Stability

Chronic dermal lesions, such as pressure ulcers, are difficult to heal. Degradable tissue scaffold systems can be employed to serve as a provisional matrix for cellular ingrowth and facilitate regenerative healing during degradation. Degradable regenerative tissue scaffold matrices can be created by crosslinking albumin with functionalized poly(ethylene glycol) (PEG) polymers. The purpose of this study was to evaluate the stability of PEG-albumin scaffold systems formed using PEG polymers with three different functionalized end chemistries by quantifying in vitro system swellability to determine the most promising PEG crosslinking polymer for wound healing applications. Of the three polymers evaluated, PEG-succinimidyl glutarate (SG) exhibited consistent gelation and handling characteristics when used as the crosslinking agent with albumin. PEG-SG polymers were identified as an appropriate synthetic crosslinking moiety in a PEG-albumin scaffold system, and further in vitro and in vivo evaluation of this scaffold system is merited.

scholarly journals Protective effect of Ruta Chalepensis L. extract on oxidative stress and liver-kidney function induced by polymicrobial sepsis in rats

2014 ◽  
Vol 10 (1) ◽  
pp. 2146-2161
Author(s):  
Mohamed Kacem ◽  
Gaëlle Simon ◽  
Aïda Elleuch ◽  
Fatma Makni Ayadi ◽  
Tahia Boudawara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Ethanolic Extract ◽  
Pathological Examination ◽  
Enzymatic Antioxidants ◽  
Ruta Chalepensis ◽  
Systemic Inflammatory Disease ◽  
Liver And Kidney

Sepsis, a systemic inflammatory disease developed after an infectious insult and remains the major cause of death in intensive care units. The aim of this study was to examine the protective effect of the ethanolic extract of Ruta chalepensis L. (ERC) against oxidative stress and liver-kidney functions in cecal and ligation puncture (CLP) rats. In vitro, the results showed that ERC rich in phenolic compounds possessed important antioxidant activity. In vivo, CLP-induced oxidative stress evidenced by the increase of the TBARS and decrease in the enzymatic antioxidants (SOD, CAT, GPX) in liver and kidney. Moreover, CLP induced liver-kidney toxicities showed by an increase in the ALT, AST, PAL, LDH, BUN and creatinine in the plasma. However, the administration of ERC to CLP-rats prevents all these disorders. Positive action of ERC was confirmed by histo-pathological examination. Therefore this study suggests that ERC could be a potential therapeutic agent for sepsis treatment.

scholarly journals Synthesis, Characterization, In-Vitro and In-Vivo Evaluation of Ketorolac Tromethamine-Loaded Hydrogels of Glutamic Acid as Controlled Release Carrier

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3541
Author(s):  
Muhammad Suhail ◽  
Chuan-Ming Shih ◽  
Jia-Yu Liu ◽  
Wan-Chu Hsieh ◽  
Yu-Wen Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Ammonium Persulfate ◽  
Low Ph ◽  
In Vivo Evaluation ◽  
Drug Solution

Glutamic acid-co-poly(acrylic acid) (GAcPAAc) hydrogels were prepared by the free radical polymerization technique using glutamic acid (GA) as a polymer, acrylic acid (AAc) as a monomer, ethylene glycol dimethylacrylate (EGDMA) as a cross-linker, and ammonium persulfate (APS) as an initiator. Increase in gel fraction was observed with the increasing concentration of glutamic acid, acrylic acid, and ethylene glycol dimethylacrylate. High percent porosity was indicated by developed hydrogels with the increase in the concentration of glutamic acid and acrylic acid, while a decrease was seen with the increasing concentration of EGDMA, respectively. Maximum swelling and drug release was exhibited at high pH 7.4 compared to low pH 1.2 by the newly synthesized hydrogels. Similarly, both swelling and drug release increased with the increasing concentration of glutamic acid and acrylic acid and decreased with the increase in ethylene glycol dimethylacrylate concentration. The drug release was considered as non-Fickian transport and partially controlled by viscoelastic relaxation of hydrogel. In-vivo study revealed that the AUC0–∞ of fabricated hydrogels significantly increased compared to the drug solution and commercial product Keten. Hence, the results indicated that the developed hydrogels could be used as a suitable carrier for controlled drug delivery.

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory
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