DNA Binding, Cleavage and Antibacterial Activity of Mononuclear Cu(II), Ni(II) and Co(II) Complexes Derived from Novel Benzothiazole Schiff Bases

Two new bis-Schiff bases containing a piperazine ring, N,N‘-bis(4-chlorobenzylidene)- and N,N‘-bis(4-cyanobenzylidene)-1,4-bis(3-aminopropyl)piperazine, were prepared by the reaction of N,N‘-bis(3-aminopropyl)piperazine with 4-chloro- and 4-cyanobenzaldehyde, respectively. The dichloro compound was fully identified by X-ray crystallography and it exhibited good antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.

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SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL ACTIVITY OF SCHIFF BASES DERIVED FROM THIOSEMICARBAZIDE, 2-ACETYL THIOPHENE AND THIOPHENE-2 ALDEHYDE

International Research Journal of Pharmacy ◽

10.7897/2230-8407.097141 ◽

2018 ◽

Vol 9 (7) ◽

pp. 153-158

Author(s):

Chandra Mohan ◽

Vinod Kumar ◽

Sarla Kumari

Keyword(s):

Antibacterial Activity ◽

Schiff Bases

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SYNTHESIS, CHARACTERIZATION, DNA BINDING AND ANTIBACTERIAL ACTIVITY OF RUTHENIUM(III) COMPLEX CONTAINING MIXED LIGANDS

Kongunadu Research Journal ◽

10.26524/krj60 ◽

2015 ◽

Vol 2 (1) ◽

pp. 24-28

Author(s):

Sampath K ◽

Jayabalakrishnan C

Keyword(s):

Antibacterial Activity ◽

Dna Binding ◽

Structural Features ◽

Inhibition Activity ◽

Spectral Techniques ◽

Mixed Ligands ◽

Physico Chemical ◽

Pharmacological Significance ◽

Growth Inhibition Activity ◽

Significant Growth Inhibition

Ruthenium(III) complex, [RuBr2(AsPh3)2L] (where L = (E)-2-(2-chlorobenzylidene)-Nmethylhydrazinecarbothioamide) have been synthesized. Structural features of the complex were determined by various physico-chemical and spectral techniques. DNA binding of the complex was investigated by absorption spectroscopy which indicated that the complex bind to DNA via intercalation and this complex ind strongly than ligand. The complex has shown significant growth inhibition activity against a panel of bacteria which indicating the pharmacological significance of the ruthenium(III) complex.

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Synthesis characterization and antibacterial studies of 4-aminoantipyrine schiff’s bases

International Journal of Applied Pharmaceutical Sciences and Research ◽

10.21477/ijapsr.v2i1.6908 ◽

2017 ◽

Vol 2 (01) ◽

pp. 8-14 ◽

Cited By ~ 1

Author(s):

K Sunand ◽

K Vinay Kumar ◽

K Ashwini ◽

P Suresh Kumar ◽

S Vishnu ◽

...

Keyword(s):

Antibacterial Activity ◽

Schiff Bases ◽

Vital Role ◽

Spectroscopic Techniques ◽

Schiff’S Bases ◽

Pharmacological Activities ◽

Schiff's Bases ◽

Ir Spectroscopic

Aim: To synthesize and evaluate 4-aminoantipyrine related schiff’s bases as antibacterial agents. Objective: To synthesize, purify, characterize and evaluate 4-aminoantipyrine. Method: Schiff bases derived from 4-aminoantipyrine play a vital role in biological and pharmacological activities. Knowing the importance of 4-aminoatipyrine schiff bases and their analogues wide varieties of bioactivities like analgesic, antiviral, antipyretic, anti-rheumatic, antimicrobial and anti-inflammatory activities have been widely studied. 4-aminoantipyrine compounds C1 (anisaldehyde), C2 (p-hydroxybenzaldehyde) and C3(vanillin) were prepared by condensation between 4-amino antipyrine and substituted aromatic benzaldehydes. The products were purified by recrystallization by using ethanol, characterized by IR spectroscopy. The N-H stretching in 4-aminoantipyrine is shown at 3430 cm-1 and -3325 cm-1. The -HC=N- stretching is observed in the range of 1508-1504 cm-1 The –OCH3 stretching is found at 1888 cm-1. 4-amino antipyrine related schiff’s bases evaluated their activity as antimicrobials in-vitro by spread plate method against E.coli. Schiff bases have potent antibacterial activity with gram negative bacteria E.coli. Results: Synthesis and characterization of a schiff bases derived from substituted benzaldehydes and 4-aminoantipyrine was evaluated and characterized with the IR spectroscopic techniques and schiff bases have shown potent antibacterial activity against E.Coli.

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