SYNTHESIS, CHARACTERIZATION, DNA BINDING AND ANTIBACTERIAL ACTIVITY OF RUTHENIUM(III) COMPLEX CONTAINING MIXED LIGANDS

Ruthenium(III) complex, [RuBr2(AsPh3)2L] (where L = (E)-2-(2-chlorobenzylidene)-Nmethylhydrazinecarbothioamide) have been synthesized. Structural features of the complex were determined by various physico-chemical and spectral techniques. DNA binding of the complex was investigated by absorption spectroscopy which indicated that the complex bind to DNA via intercalation and this complex ind strongly than ligand. The complex has shown significant growth inhibition activity against a panel of bacteria which indicating the pharmacological significance of the ruthenium(III) complex.

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New dimeric carbazole–benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

Organic & Biomolecular Chemistry ◽

10.1039/c5ob00675a ◽

2015 ◽

Vol 13 (30) ◽

pp. 8335-8348 ◽

Cited By ~ 19

Author(s):

Basudeb Maji ◽

Krishan Kumar ◽

K. Muniyappa ◽

Santanu Bhattacharya

Keyword(s):

Dna Binding ◽

Inhibition Activity ◽

Telomerase Inhibition ◽

Quadruplex Dna ◽

Telomerase Inhibitors ◽

Mixed Ligands ◽

G Quadruplex

G-quadruplex DNA binding dimeric ligands and their telomerase inhibition activity are reported.

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Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

Oriental Journal Of Chemistry ◽

10.13005/ojc/370516 ◽

2021 ◽

Vol 37 (5) ◽

pp. 1125-1131

Author(s):

Y.B. Nagamani ◽

K. Hussain Reddy ◽

K. Srinivasulu ◽

D. Dhanalakshmi ◽

K. Anuja

Keyword(s):

Antibacterial Activity ◽

Dna Binding ◽

Binding Constants ◽

Dna Interactions ◽

Bivalent Metal ◽

Binding Properties ◽

Hydrazone Ligand ◽

Metal Compounds ◽

Physico Chemical ◽

Dna Binding Properties

Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

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COMPARATIVE ANTIBACTERIAL EFFICACY OF METHANOL AND AQUEOUS EXTRACT OF M. PANICULATA AGAINST X. CITRI AND X. CAMPESTRIS

PLANT ARCHIVES ◽

10.51470/plantarchives.2021.v21.no1.253 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ankita Sharma

Keyword(s):

Antibacterial Activity ◽

Leaf Extract ◽

Plant Pathogens ◽

Diffusion Method ◽

Antibacterial Efficacy ◽

Inhibition Activity ◽

Murraya Paniculata ◽

Growth Inhibition Activity ◽

Antibacterial Potential ◽

Agar Well Diffusion Method

In this study, Murraya paniculata was analysed for its antibacterial activity by using different solvents like methanol and aqueous against two plant pathogens i.e. X. citri and X. campestris and observed the growth inhibition activity ranging from 20 µl - 100 µl. The antibacterial potential of M. paniculata (leaf and stem) by using two different solvents was studied by agar well diffusion method and we observed that at 100 µl it’s showed significant result against both the tested bacteria. Highest antibacterial activity was observed by the methanolic leaf extract of M. paniculata against X. citri i.e.13.22±0.05 mm at 100 µl of concentration.

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Design, Synthesis, Molecular Modelling and Anticancer Activities of New Fused Phenanthrolines

Molecules ◽

10.3390/molecules25030527 ◽

2020 ◽

Vol 25 (3) ◽

pp. 527 ◽

Cited By ~ 1

Author(s):

Cristina Maria Al Matarneh ◽

Roxana Maria Amarandi ◽

Anda Mihaela Craciun ◽

Ionel I. Mangalagiu ◽

Gheorghita Zbancioc ◽

...

Keyword(s):

Cell Lines ◽

Human Cancer ◽

Docking Studies ◽

Inhibition Activity ◽

Anticancer Activities ◽

Design Synthesis ◽

Human Cancer Cell Lines ◽

Colchicine Binding Site ◽

Growth Inhibition Activity ◽

Significant Growth Inhibition

Three series of fused pyrrolophenanthroline derivatives were designed as analogues of phenstatin and synthesized in two steps starting with 1,7-phenanthroline, 4,7-phenanthroline and 1,10-phenanthroline, respectively. Two (Compounds 8a and 11c) of the four compounds tested against a panel of sixty human cancer cell lines of the National Cancer Institute (NCI) exhibited significant growth inhibition activity on several cell lines. Compound 11c showed a broad spectrum in terms of antiproliferative efficacy with GI50 values in the range of 0.296 to 250 μM. Molecular docking studies indicated that Compounds 8a and 11c are accommodated in the colchicine binding site of tubulin in two different ways.

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Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base

Chemical Papers ◽

10.2478/s11696-010-0003-0 ◽

2010 ◽

Vol 64 (3) ◽

Cited By ~ 19

Author(s):

Natarajan Raman ◽

Ramaraj Jeyamurugan ◽

Mariyyappan Subbulakshmi ◽

Raja Boominathan ◽

Chithu Yuvarajan

Keyword(s):

Schiff Base ◽

Dna Binding ◽

Dna Cleavage ◽

Double Helix ◽

Structural Features ◽

Schiff Base Complexes ◽

Diffusion Method ◽

Spectral Techniques ◽

Antimicrobial Studies

AbstractA novel series of Co(II), Ni(II), Cu(II), Zn(II), and VO(IV) complexes has been synthesized from the Schiff base derived from 4-[(3,4-dimethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one and 1,2-diaminobenzene. Structural features were determined by analytical and spectral techniques. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods and viscosity measurements. Experimental results indicate that the complexes are able to form adducts with DNA and to distort the double helix by changing the base stacking. Lower DNA affinity of the VO(IV) complex is caused by the change of coordination geometry by the vanadyl ion resulting in a somewhat unfavorable configuration for the DNA binding. Oxidative DNA cleavage activities of the complexes were studied with supercoiled (SC) pUC19 DNA using gel electrophoresis; the mechanism studies revealed that the hydroxyl radical is likely to be the reactive species responsible for the cleavage of pUC19 DNA by the synthesized complexes. The in vitro antimicrobial screening effects of the investigated compounds were monitored by the disc diffusion method. The synthesized Schiff base complexes exhibit higher antimicrobial activity than the respective free Schiff base.

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Mechanistic studies of ipomoeassin F for its cell growth inhibition activity

10.1021/scimeetings.0c06615 ◽

2020 ◽

Author(s):

Lauren Andrews ◽

Wei Shi ◽

Kwabena Duah

Keyword(s):

Cell Growth ◽

Growth Inhibition ◽

Inhibition Activity ◽

Mechanistic Studies ◽

Cell Growth Inhibition ◽

Growth Inhibition Activity

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Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666201019152206 ◽

2020 ◽

Vol 23 ◽

Author(s):

Hadis Khodadad ◽

Farhad Hatamjafari ◽

Khalil Pourshamsian ◽

Babak Sadeghi

Keyword(s):

Antibacterial Activity ◽

Aromatic Aldehydes ◽

Catalytic Amount ◽

Antibacterial Activities ◽

Structural Features ◽

Biological Evaluation ◽

Aureus Strain ◽

Microwave Assisted Synthesis ◽

Pyrazole Derivatives ◽

Microwave Assisted

Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.

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Chitosan hydrogel/silk fibroin/Mg(OH)2 nanobiocomposite as a novel scaffold with antimicrobial activity and improved mechanical properties

Scientific Reports ◽

10.1038/s41598-020-80133-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Reza Eivazzadeh-Keihan ◽

Fateme Radinekiyan ◽

Hooman Aghamirza Moghim Aliabadi ◽

Sima Sukhtezari ◽

Behnam Tahmasebi ◽

...

Keyword(s):

Antibacterial Activity ◽

Cell Viability ◽

Silk Fibroin ◽

Analytical Techniques ◽

Structural Features ◽

Mechanical Tests ◽

Chitosan Hydrogel ◽

Biological Capacity ◽

Ft Ir ◽

Novel Scaffold

AbstractHerein, a novel nanobiocomposite scaffold based on modifying synthesized cross-linked terephthaloyl thiourea-chitosan hydrogel (CTT-CS hydrogel) substrate using the extracted silk fibroin (SF) biopolymer and prepared Mg(OH)2 nanoparticles was designed and synthesized. The biological capacity of this nanobiocomposite scaffold was evaluated by cell viability method, red blood cells hemolytic and anti-biofilm assays. According to the obtained results from 3 and 7 days, the cell viability of CTT-CS/SF/Mg(OH)2 nanobiocomposite scaffold was accompanied by a considerable increment from 62.5 to 89.6% respectively. Furthermore, its low hemolytic effect (4.5%), and as well, the high anti-biofilm activity and prevention of the P. aeruginosa biofilm formation confirmed its promising hemocompatibility and antibacterial activity. Apart from the cell viability, blood biocompatibility, and antibacterial activity of CTT-CS/SF/Mg(OH)2 nanobiocomposite scaffold, its structural features were characterized using spectral and analytical techniques (FT-IR, EDX, FE-SEM and TG). As well as, given the mechanical tests, it was indicated that the addition of SF and Mg(OH)2 nanoparticles to the CTT-CS hydrogel could improve its compressive strength from 65.42 to 649.56 kPa.

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