Feasibility Study of a Sensor-Based Autonomous Load Control Exercise Training System for COPD Patients

2014 ◽  
Vol 39 (1) ◽  
Author(s):  
Bianying Song ◽  
Marcus Becker ◽  
Matthias Gietzelt ◽  
Reinhold Haux ◽  
Martin Kohlmann ◽  
...  
Keyword(s):  
Exercise Training ◽  
Feasibility Study ◽  
Training System ◽  
Load Control ◽  
Copd Patients ◽  
Control Exercise

scholarly journals Comprehensive exercise training improves ventilatory muscle function and reduces dyspnea perception in patients with COPD

2016 ◽  
Vol 71 (3) ◽  
Author(s):  
F. Cortopassi ◽  
A.A.M. Castro ◽  
E.F. Porto ◽  
M. Colucci ◽  
G. Fonseca ◽  
...  
Keyword(s):  
Exercise Training ◽  
Respiratory Muscles ◽  
Exercise Programme ◽  
Lower Limbs ◽  
Test Time ◽  
Chronic Obstructive ◽  
Endurance Test ◽  
Incremental Test ◽  
Copd Patients ◽  
Before And After

Background. Comprehensive exercise training (CET) is an efficient strategy to decrease dyspnea perception in chronic obstructive pulmonary disease (COPD) and may result in significant improvement in ventilatory muscles function. Our aim was to evaluate the effects of general exercise training on dyspnea perception and on respiratory muscles strength in COPD patients. Methods. Consecutive COPD patients were enrolled to complete a CET programme. The patients underwent a routine that included a global warm up, upper and lower limbs endurance exercise as well as stretching and relaxation. Before and after the CET programme, patients completed maximal inspiratory (PImax) and expiratory (PEmax) pressures measurements, maximal incremental test, endurance test, and 6-min walk distance (6MWD). Results. 71 patients (52 male). Mean age 67.6±8.6 years, FEV1 (%) 44.2±16.2 and Mahler dyspnea scale 6.4±1.8. The results before and after the exercise programme were: PImax 64.7±22.9 vs. 75.5±23.7 cmH2O (p=0.001), PEmax 110.8±28.1 vs. 120.4±28.1 cmH2O (p=0.004), 6MWD 510.6±90.3 vs. 528.2±99.7 metres (p=0.88), time of incremental test 672±135 vs. 856±226 sec (p<0.0001). Compared with the pre exercise programme, we observed a significant reduction on Borg dyspnea scale (6.1±2.8 to 3.6±2.3, p<0.0001) as well as a longer test time (504±218 to 1.038±841, p<0.0001) at the end of the endurance test after CET programme. Improvement of PImax correlated negatively with dyspnea perception at iso-time during the endurance test (r= -0.33, p=0.03). Conclusions. Our results confirm that CET is associated with significant improvement in PImax, PEmax and provide evidence demonstrating that CET reduces dyspnea perception in patients with COPD.

scholarly journals Effects of exercise training on quadriceps muscle gene expression in chronic obstructive pulmonary disease

2007 ◽  
Vol 102 (5) ◽  
pp. 1976-1984 ◽  
Author(s):  
Shlomit Radom-Aizik ◽  
Naftali Kaminski ◽  
Shlomo Hayek ◽  
Hillel Halkin ◽  
Dan M. Cooper ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Obstructive Pulmonary Disease ◽  
Exercise Training ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Muscle Gene Expression ◽  
Copd Patients ◽  
Before And After ◽  
Ubiquitin Proteasome ◽  
Muscle Gene

Exercise capacity and training response are limited in chronic obstructive pulmonary disease (COPD), but the extent to which this is related to altered skeletal muscle function is not fully understood. To test the hypothesis that muscle gene expression is altered in COPD, we performed needle biopsies from the vastus lateralis of six COPD patients and five sedentary age-matched healthy men, before and after 3 mo of exercise training. RNA was hybridized to Affymetrix U133A Genechip arrays. In addition, peak O2 uptake and other functional parameters (e.g., 6-min walk) were measured before and after training. The 6-min walk test increased significantly following training in both groups (53.6 ± 18.6 m in controls, P = 0.045; 37.1 ± 6.7 m in COPD, P = 0.002), but peak O2 uptake increased only in controls (19.4 ± 4.5%, P = 0.011). Training significantly altered muscle gene expression in both groups, but the number of affected genes was lower in the COPD patients (231) compared with controls (573). Genes related to energy pathways had higher expression in trained controls. In contrast, oxidative stress, ubiquitin proteasome, and COX gene pathways had higher expression in trained COPD patients, and some genes (e.g., COX11, COX15, and MAPK-9) were upregulated by training only in COPD patients. We conclude that both COPD and control subjects demonstrated functional responses to training but with somewhat different patterns in muscle gene expression. The pathways that are uniquely induced by exercise in COPD (e.g., ubiquitin proteasome and COX) might indicate a greater degree of tissue stress (perhaps by altered O2 and CO2 dynamics) than in controls.

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