Characterization of Tannase Protein Sequences of Bacteria and Fungi: An In Silico Study

2012 ◽  
Vol 31 (4) ◽  
pp. 306-327 ◽  
Author(s):  
Amrita Banerjee ◽  
Arijit Jana ◽  
Bikash R. Pati ◽  
Keshab C. Mondal ◽  
Pradeep K. Das Mohapatra
Keyword(s):  
In Silico ◽  
Protein Sequences ◽  
In Silico Study ◽  
Bacteria And Fungi

Simultaneous characterization of nine isolated flavonoids in Iranian Dracocephalum species and in silico study of their inhibitory properties against MTH1 enzyme

2022 ◽  
Vol 146 ◽  
pp. 254-261
Author(s):  
Shahrbanou Ashrafian ◽  
Mahdi Moridi Farimani ◽  
Ali Sonboli ◽  
Hossein Ashrafian ◽  
Maryam Kabiri ◽  
...  
Keyword(s):  
In Silico ◽  
In Silico Study

Characterization of phthalate reductase from Ralstonia eutropha CH34 and in silico study of phthalate dioxygenase and phthalate reductase interaction

2019 ◽  
Vol 90 ◽  
pp. 161-170 ◽  
Author(s):  
Neha Singh ◽  
Vikram Dalal ◽  
Vijay Kumar ◽  
Monica Sharma ◽  
Pravindra Kumar
Keyword(s):  
In Silico ◽  
Ralstonia Eutropha ◽  
In Silico Study

scholarly journals In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors

2016 ◽  
Vol 64 ◽  
pp. 121-130 ◽  
Author(s):  
Simone Brogi ◽  
Simone Giovani ◽  
Margherita Brindisi ◽  
Sandra Gemma ◽  
Ettore Novellino ◽  
...  
Keyword(s):  
In Silico ◽  
Plasmodium Species ◽  
In Silico Study

scholarly journals Characterization of altered genomic landscape of SARS-CoV-2 variants isolated in Saudi Arabia in a comparative in silico study

2021 ◽  
Author(s):  
Mohammad Fahad Ullah ◽  
Tarig M.S. Alnoura ◽  
Elmutuz H. Elssaig ◽  
Eltayib H. Ahmed-Abakur
Keyword(s):  
Saudi Arabia ◽  
In Silico ◽  
Genomic Landscape ◽  
In Silico Study

scholarly journals Characteristics of hemolysins from pathogenic bacteria in tropical aquaculture: an in-silico study

2021 ◽  
Vol 890 (1) ◽  
pp. 012017
Author(s):  
Dewi Syahidah
Keyword(s):  
Blood Cells ◽  
In Silico ◽  
Pathogenic Bacteria ◽  
Protein Sequences ◽  
Host Cells ◽  
Bacterial Isolates ◽  
Damage Cell ◽  
In Silico Study ◽  
Tropical Aquaculture

Abstract Some species of known pathogenic bacteria isolates in tropical aquaculture produces hemolysin. Hemolysin can be identified based on its ability to break down red blood cells in vitro. Some hemolysin is a pore-shaped poison that can damage cell membranes and kill host cells. The character of the 13 sequences of hemolysin protein in several pathogenic bacterial isolates in tropical aquaculture was analysed using the NCBI protein bioinformatics database. The phylogenetic tree was generated, and the analysis was conducted using the base character method (Maximum Parsimony) of Mega 6.06 software. The result showed that there are two big family of hemolysin from the known pathogenic bacteria. The closest characteristics of protein sequences were hemolysin of Streptococcus agalacticae and of S. iniae.

Characterization of Forced Degradation Products & Related Substances of Bilastine by Online LC-Q-TOF-MS and In-silico Study of Characterized Compounds

2021 ◽  
Vol 11 (4) ◽  
pp. 563-579
Author(s):  
Amrej Singh Yadav ◽  
Aishwarya Prabha ◽  
Divya Dornala ◽  
Debasish Swain ◽  
Dilep Kumar Sigalapalli ◽  
...  
Keyword(s):  
In Silico ◽  
Degradation Products ◽  
Forced Degradation ◽  
Related Substances ◽  
In Silico Study ◽  
Tof Ms

scholarly journals Functional and Structural Characterization of SARS-Cov-2 Spike Protein: An In Silico Study

2021 ◽  
Vol 31 (2) ◽  
Author(s):  
Hadi Sedigh Ebrahim-Saraie ◽  
Behzad Dehghani ◽  
Ali Mojtahedi ◽  
Mohammad Shenagari ◽  
Meysam Hasannejad-Bibalan
Keyword(s):  
B Cell ◽  
In Silico ◽  
Disulfide Bonds ◽  
Deep Understanding ◽  
Structural Features ◽  
Spike Protein ◽  
Tertiary Structures ◽  
In Silico Study ◽  
High Prevalence

BACKGROUND፡ Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global outbreak of coronavirus disease 2019 (Covid-19), which has been considered as a pandemic by WHO. SARS-CoV-2 encodes four major structural proteins, among which spike protein has always been a main target for new vaccine studies. This in silico study aimed to investigate some physicochemical, functional, immunological, and structural features of spike protein using several bioinformatics tools.METHOD: We retrieved all SARS-CoV-2 spike protein sequences from different countries registered in NCBI GenBank. CLC Sequence Viewer was employed to translate and align the sequences, and several programs were utilized to predict B-cell epitopes. Modification sites such as phosphorylation, glycosylation, and disulfide bonds were defined. Secondary and tertiary structures of all sequences were further computed.RESULTS: Some mutations were determined, where only one (D614G) had a high prevalence. The mutations did not impact the B-cell and physicochemical properties of the spike protein. Seven disulfide bonds were specified and also predicted in several N-link glycosylation and phosphorylation sites. The results also indicated that spike protein is a non-allergen.CONCLUSION: In summary, our findings provided a deep understanding of spike protein, which can be valuable for future studies on SARS CoV-2 infections and design of new vaccines.

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