Interactions Between Amyloid-β (1-42) and Hydroxyapatite-Cholesterol Spherules Associated with Age-Related Macular Degeneration

2021 ◽  
Author(s):  
Renuka Ranjan ◽  
Arvind M. Kayastha ◽  
Neeraj Sinha
Keyword(s):  
Macular Degeneration ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration

2021 ◽  
Vol 6 (1) ◽  
pp. e000774
Author(s):  
Minwei Wang ◽  
Shiqi Su ◽  
Shaoyun Jiang ◽  
Xinghuai Sun ◽  
Jiantao Wang
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Vision Loss ◽  
Cell Structure ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Amyloid Β Peptide ◽  
Age Related

Age-related macular degeneration (AMD) is the most common eye disease in elderly patients, which could lead to irreversible vision loss and blindness. Increasing evidence indicates that amyloid β-peptide (Aβ) might be associated with the pathogenesis of AMD. In this review, we would like to summarise the current findings in this field. The literature search was done from 1995 to Feb, 2021 with following keywords, ‘Amyloid β-peptide and age-related macular degeneration’, ‘Inflammation and age-related macular degeneration’, ‘Angiogenesis and age-related macular degeneration’, ‘Actin cytoskeleton and amyloid β-peptide’, ‘Mitochondrial dysfunction and amyloid β-peptide’, ‘Ribosomal dysregulation and amyloid β-peptide’ using search engines Pubmed, Google Scholar and Web of Science. Aβ congregates in subretinal drusen of patients with AMD and participates in the pathogenesis of AMD through enhancing inflammatory activity, inducing mitochondrial dysfunction, altering ribosomal function, regulating the lysosomal pathway, affecting RNA splicing, modulating angiogenesis and modifying cell structure in AMD. The methods targeting Aβ are shown to inhibit inflammatory signalling pathway and restore the function of retinal pigment epithelium cells and photoreceptor cells in the subretinal region. Targeting Aβ may provide a novel therapeutic strategy for AMD.

scholarly journals Activated microglia-induced neuroinflammatory cytokines lead to photoreceptor apoptosis in age-related macular degeneration-like mice model

2020 ◽  
Author(s):  
Jing Wu ◽  
Ge Gao ◽  
Fanjun Shi ◽  
Chaoyang Zhang ◽  
Hai Xie ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Inflammatory Cytokines ◽  
Critical Role ◽  
Amyloid Β ◽  
Mapk Signaling ◽  
Microglia Activation ◽  
Age Related Macular Degeneration ◽  
Mice Model ◽  
Activated Microglia ◽  
Age Related

Abstract Background Age-related macular degeneration (AMD) is mainly characterized by progressive deposits of drusen and photoreceptor apoptosis. Due to amyloid β (Aβ) is the main component of drusen, there is a great possibility that Aβ-induced activated microglia leads to inflammation, and plays a critical role in the pathogenesis of AMD. However, the relationship between activated microglia-mediated neuroinflammatory cytokines and photoreceptor apoptosis still remains unclarified. Results In this study, we demonstrated that subretinal injection of Aβ1−42 induced the microglia activation and increased inflammatory cytokines, gave rise to photoreceptor apoptosis in mice. Our results were verified in vitro by co-culture of Aβ1−42 activated primary microglia and photoreceptor cell line 661W, and we also performed that p38 MAPK signaling pathway was involved in Aβ1−42 induced microglia activation and inflammatory cytokines release. Conclusions Overall, our findings indicated that activated microglia-mediated neuroinflammatory cytokines contributed to photoreceptor apoptosis under the stimulation of Aβ1−42. Moreover, this study will provide a potential preventive and therapeutic approach for AMD treatment.

A Randomized Phase 2 Study of an Anti–Amyloid β Monoclonal Antibody in Geographic Atrophy Secondary to Age-Related Macular Degeneration

2018 ◽  
Vol 2 (10) ◽  
pp. 1028-1040 ◽  
Author(s):  
Philip J. Rosenfeld ◽  
Brian Berger ◽  
Elias Reichel ◽  
Ronald P. Danis ◽  
Angie Gress ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Macular Degeneration ◽  
Amyloid Β ◽  
Geographic Atrophy ◽  
Age Related Macular Degeneration ◽  
Phase 2 ◽  
Age Related ◽  
Phase 2 Study ◽  
Randomized Phase 2

scholarly journals Altered Function of Factor I Caused by Amyloid β: Implication for Pathogenesis of Age-Related Macular Degeneration from Drusen

2008 ◽  
Vol 181 (1) ◽  
pp. 712-720 ◽  
Author(s):  
Jiying Wang ◽  
Kyoko Ohno-Matsui ◽  
Takeshi Yoshida ◽  
Ariko Kojima ◽  
Noriaki Shimada ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Factor I ◽  
Age Related

scholarly journals AMYLOID-β RISK FACTOR FOR AGE-RELATED MACULAR DEGENERATION

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 427-428
Author(s):  
A.P. Bobrov ◽  
V.V. Ermilov ◽  
A. Smirnov
Keyword(s):  
Risk Factor ◽  
Macular Degeneration ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Age Related

P2X7-pannexin-1 and amyloid β-induced oxysterol input in human retinal cell: Role in age-related macular degeneration?

Biochimie ◽  
2016 ◽  
Vol 127 ◽  
pp. 70-78 ◽  
Author(s):  
Elodie Olivier ◽  
Mélody Dutot ◽  
Anne Regazzetti ◽  
Teddy Leguillier ◽  
Delphine Dargère ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Retinal Cell ◽  
Pannexin 1 ◽  
Age Related
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