Fabrication and characterization of bioactive chitosan microspheres incorporated with mesoporous silica nanoparticles for biomedical applications

The purpose of this article is to synthesize the thiol-and carboxyl-bifunctionalized mesoporous silica nanoparticles (CMS-SH-COOH). CMS-SH-COOH was successfully synthesized by co-condensation and post-grafting methods. Moreover, the particle size and structural properties of CMS-SH-COOH were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR). The obtained results indicated that the CMS-SH-COOH presented a uniform spherical shape with a wormhole arrangement of the mesopores and a relatively narrow paticle distribition. Therefore, the CMS-SH-COOH might be a great potential carrier for the drug delivery system in the future.

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Synthesis and characterization of pore size-tunable magnetic mesoporous silica nanoparticles

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2011.05.038 ◽

2011 ◽

Vol 361 (1) ◽

pp. 16-24 ◽

Cited By ~ 113

Author(s):

Jixi Zhang ◽

Xu Li ◽

Jessica M. Rosenholm ◽

Hong-chen Gu

Keyword(s):

Mesoporous Silica ◽

Pore Size ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Synthesis And Characterization ◽

Magnetic Mesoporous Silica

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Synthesis and Physicochemical Characterization of MesoporousSiO2Nanoparticles

Journal of Nanomaterials ◽

10.1155/2014/176015 ◽

2014 ◽

Vol 2014 ◽

pp. 1-12 ◽

Cited By ~ 11

Author(s):

Dharani Das ◽

Yong Yang ◽

Julie S. O’Brien ◽

Dalibor Breznan ◽

Surendra Nimesh ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Physicochemical Characterization ◽

Organic Content ◽

Narrow Particle Size Distribution ◽

Surface Functionality ◽

Wide Range ◽

Surface Modified

There exists a knowledge gap in understanding potential toxicity of mesoporous silica nanoparticles. A critical step in assessing toxicity of these particles is to have a wide size range with different chemistries and physicochemical properties. There are several challenges when synthesizing mesoporous silica nanoparticles over a wide range of sizes including (1) nonuniform synthesis protocols using the same starting materials, (2) the low material yield in a single batch synthesis (especially for particles below 60–70 nm), and (3) morphological instability during surfactant removal process and surface modifications. In this study, we synthesized a library of mesoporous silica nanoparticles with approximate particle sizes of 25, 70, 100, 170, and 600 nm. Surfaces of the silica nanoparticles were modified with hydrophilic-CH2–(CH2)2–COOH and relatively hydrophobic-CH2–(CH2)10–COOH functional groups. All silica nanoparticles were analysed for morphology, surface functionality, surface area/pore volume, surface organic content, and dispersion characteristics in liquid media. Our analysis revealed the synthesis of a spectrum of monodisperse bare and surface modified mesoporous silica nanoparticles with a narrow particle size distribution and devoid of cocontaminants critical for toxicity studies. Complete physicochemical characterization of these synthetic mesoporous silica nanoparticles will permit systematic toxicology studies for investigation of structure-activity relationships.

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