Synthesis and Physicochemical Characterization of MesoporousSiO2Nanoparticles

There exists a knowledge gap in understanding potential toxicity of mesoporous silica nanoparticles. A critical step in assessing toxicity of these particles is to have a wide size range with different chemistries and physicochemical properties. There are several challenges when synthesizing mesoporous silica nanoparticles over a wide range of sizes including (1) nonuniform synthesis protocols using the same starting materials, (2) the low material yield in a single batch synthesis (especially for particles below 60–70 nm), and (3) morphological instability during surfactant removal process and surface modifications. In this study, we synthesized a library of mesoporous silica nanoparticles with approximate particle sizes of 25, 70, 100, 170, and 600 nm. Surfaces of the silica nanoparticles were modified with hydrophilic-CH2–(CH2)2–COOH and relatively hydrophobic-CH2–(CH2)10–COOH functional groups. All silica nanoparticles were analysed for morphology, surface functionality, surface area/pore volume, surface organic content, and dispersion characteristics in liquid media. Our analysis revealed the synthesis of a spectrum of monodisperse bare and surface modified mesoporous silica nanoparticles with a narrow particle size distribution and devoid of cocontaminants critical for toxicity studies. Complete physicochemical characterization of these synthetic mesoporous silica nanoparticles will permit systematic toxicology studies for investigation of structure-activity relationships.

Download Full-text

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

Materials ◽

10.3390/ma14123337 ◽

2021 ◽

Vol 14 (12) ◽

pp. 3337

Author(s):

Sara Hooshmand ◽

Sahar Mollazadeh ◽

Negar Akrami ◽

Mehrnoosh Ghanad ◽

Ahmed El-Fiqi ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Skin Regeneration ◽

Bioactive Molecules ◽

Wound Management ◽

Bioactive Glasses ◽

Wide Range

Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

Download Full-text

Lipase Immobilization in Mesoporous Silica Nanoparticles for Biofuel Production

Catalysts ◽

10.3390/catal11050629 ◽

2021 ◽

Vol 11 (5) ◽

pp. 629

Author(s):

Aniello Costantini ◽

Valeria Califano

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mechanical Stability ◽

Mesoporous Silica Nanoparticles ◽

Physiological Role ◽

Biodiesel Production ◽

Biofuel Production ◽

Hydroxyl Groups ◽

Lipase Immobilization ◽

Wide Range

Lipases are ubiquitous enzymes whose physiological role is the hydrolysis of triacylglycerol into fatty acids. They are the most studied and industrially interesting enzymes, thanks to their versatility to promote a plethora of reactions on a wide range of substrates. In fact, depending on the reaction conditions, they can also catalyze synthesis reactions, such as esterification, acidolysis and transesterification. The latter is particularly important for biodiesel production. Biodiesel can be produced from animal fats or vegetable oils and is considered as a biodegradable, non-toxic and renewable energy source. The use of lipases as industrial catalysts is subordinated to their immobilization on insoluble supports, to allow multiple uses and use in continuous processes, but also to stabilize the enzyme, intrinsically prone to denaturation with consequent loss of activity. Among the materials that can be used for lipase immobilization, mesoporous silica nanoparticles represent a good choice due to the combination of thermal and mechanical stability with controlled textural characteristics. Moreover, the presence of abundant surface hydroxyl groups allows for easy chemical surface functionalization. This latter aspect has the main importance since lipases have a high affinity with hydrophobic supports. The objective of this work is to provide an overview of the recent progress of lipase immobilization in mesoporous silica nanoparticles with a focus on biodiesel production.

Download Full-text

Synthesis and Characterization of Hollow Mesoporous Silica Nanoparticles for Smart Corrosion Protection

Nanomaterials ◽

10.3390/nano8070478 ◽

2018 ◽

Vol 8 (7) ◽

pp. 478 ◽

Cited By ~ 13

Author(s):

Cristina Zea ◽

Jenifer Alcántara ◽

Rosa Barranco-García ◽

Manuel Morcillo ◽

Daniel de la Fuente

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Corrosion Protection ◽

Mesoporous Silica Nanoparticles ◽

Synthesis And Characterization ◽

Hollow Mesoporous Silica

Download Full-text

Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery

Asian Journal of Pharmaceutical Sciences ◽

10.1016/j.ajps.2018.01.006 ◽

2018 ◽

Vol 13 (6) ◽

pp. 592-599 ◽

Cited By ~ 7

Author(s):

Anna Slita ◽

Anna Egorova ◽

Eudald Casals ◽

Anton Kiselev ◽

Jessica M. Rosenholm

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Sirna Delivery

Download Full-text

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles

Pharmaceutics ◽

10.3390/pharmaceutics10040250 ◽

2018 ◽

Vol 10 (4) ◽

pp. 250 ◽

Cited By ~ 10

Author(s):

Alessandra Nigro ◽

Michele Pellegrino ◽

Marianna Greco ◽

Alessandra Comandè ◽

Diego Sisci ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Biological Tissues ◽

Drug Dosage ◽

Synthesis Process ◽

Extensive Literature ◽

Innovative Strategies ◽

Wide Range

Advances in nanotechnology for drug delivery are fostering significant progress in medicine and diagnostics. The multidisciplinary nature of the nanotechnology field encouraged the development of innovative strategies and materials to treat a wide range of diseases in a highly specific way, which allows reducing the drug dosage and, consequently, improving the patient’s compliance. Due to their good biocompatibility, easy synthesis, and high versatility, inorganic frameworks represent a valid tool to achieve this aim. In this context, Mesoporous Silica Nanoparticles (MSNs) are emerging in the biomedical field. For their ordered porosity and high functionalizable surface, achievable with an inexpensive synthesis process and being non-hazardous to biological tissues, MSNs offer ideal solutions to host, protect, and transport drugs to specific target sites. Extensive literature exists on the use of MSNs as targeted vehicles for systemic (chemo) therapy and for imaging/diagnostic purposes. However, the aim of this review is to give an overview of the last updates on the potential applications of the MSNs for Topical Drug Delivery (TDD) and as drug delivery systems into the brain, discussing their performances and advantages in dealing with these intriguing biological barriers.

Download Full-text

Construction and characterization of a temperature-responsive nanocarrier for imidacloprid based on mesoporous silica nanoparticles

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2020.111464 ◽

2021 ◽

Vol 198 ◽

pp. 111464

Author(s):

Pengji Yao ◽

Aihua Zou ◽

Zhenfen Tian ◽

Wenyan Meng ◽

Xialun Fang ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Temperature Responsive

Download Full-text

Synthesis and Characterization of Thiol- and Carboxyl-Functionalized Mesoporous Silica Nanoparticles

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1142.220 ◽

2017 ◽

Vol 1142 ◽

pp. 220-224 ◽

Cited By ~ 1

Author(s):

Wan Xia Wang ◽

Yu Wang ◽

Hua Meng Gong ◽

Hong Hao Sun ◽

Ming Xing Liu

Keyword(s):

Electron Microscopy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Spherical Shape ◽

Synthesis And Characterization ◽

Functionalized Mesoporous Silica ◽

Transmission Electron ◽

Ft Ir

The purpose of this article is to synthesize the thiol-and carboxyl-bifunctionalized mesoporous silica nanoparticles (CMS-SH-COOH). CMS-SH-COOH was successfully synthesized by co-condensation and post-grafting methods. Moreover, the particle size and structural properties of CMS-SH-COOH were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR). The obtained results indicated that the CMS-SH-COOH presented a uniform spherical shape with a wormhole arrangement of the mesopores and a relatively narrow paticle distribition. Therefore, the CMS-SH-COOH might be a great potential carrier for the drug delivery system in the future.

Download Full-text