Inhibitory Control Mediates the Associations Between Parenting Practices and Depressive Symptoms in Adolescents: The Moderating Role of Catechol-O-Methyltransferase (COMT) Gene

2021 ◽  
Author(s):  
Yanmiao Cao ◽  
Guanghui Chen ◽  
Linqin Ji ◽  
Wenxin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Inhibitory Control ◽  
Parenting Practices ◽  
Comt Gene ◽  
Moderating Role

scholarly journals Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaonan Lin ◽  
Yanmiao Cao ◽  
Linqin Ji ◽  
Wenxin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Peer Victimization ◽  
Inhibitory Control ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Chinese Han ◽  
Mediating Role ◽  
Adolescent Depressive Symptoms

AbstractMany efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.

scholarly journals Are Aspects of Twitter Use Associated with Reduced Depressive Symptoms? The Moderating Role of In-Person Social Support

2019 ◽  
Vol 22 (11) ◽  
pp. 692-699 ◽  
Author(s):  
David A. Cole ◽  
Elizabeth A. Nick ◽  
Gergely Varga ◽  
Darcy Smith ◽  
Rachel L. Zelkowitz ◽  
...  
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Moderating Role

scholarly journals Activity Limitations and Depressive Symptoms Among Older Couples: The Moderating Role of Spousal Care

2019 ◽  
Author(s):  
Sae Hwang Han ◽  
Kyungmin Kim ◽  
Jeffrey A Burr
Keyword(s):  
Depressive Symptoms ◽  
Daily Living ◽  
Activity Limitations ◽  
Moderating Effects ◽  
Older Couples ◽  
Spousal Caregiving ◽  
Living Related ◽  
Moderating Role ◽  
Retirement Study

Abstract Objectives Limitations in performing basic daily activities, as well as spousal caregiving that arises from activity limitations, are important factors that have ramifications for mental health among couples. The objective of this study was to investigate the interplay of these factors by focusing on whether the associations between activity limitations and depressive symptoms among coupled-individuals were moderated by receipt and provision of spousal care. Methods Longitudinal household data from the Health and Retirement Study (2004–2014; dyad N = 6,614) were analyzed to estimate within-person associations between one’s own and spousal activity limitations, receipt and provision of spousal care, and depressive symptoms. Results Findings showed a consistent link between one’s own activity limitations and depressive symptoms for both spouses, whereas spousal activity limitations were associated with depressive symptoms for wives only. We also found moderating effects of spousal care in the link between one’s own and spousal activity limitations and depressive symptoms. Discussion Receipt and provision of activities of daily living-related assistance may contextualize the association between activity limitations and depressive symptoms among older coupled-individuals in a direction that could alleviate or aggravate the risk of depression.

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