Helically coiled heat exchangers are globally used in various industrial applications for their high heat transfer performance and compact size. Nanofluids can provide excellent thermal performance of this type of heat exchangers. In the present study, the effect of different nanofluids on the heat transfer performance in a helically coiled heat exchanger is examined. Four different types of nanofluids CuO/water, Al2O3/water, SiO2/water, and ZnO/water with volume fractions 1 vol.% to 4 vol.% was used throughout this analysis and volume flow rate was remained constant at 3 LPM. Results show that the heat transfer coefficient is high for higher particle volume concentration of CuO/water, Al2O3/water and ZnO/water nanofluids, while the values of the friction factor and pressure drop significantly increase with the increase of nanoparticle volume concentration. On the contrary, low heat transfer coefficient was found in higher concentration of SiO2/water nanofluids. The highest enhancement of heat transfer coefficient and lowest friction factor occurred for CuO/water nanofluids among the four nanofluids. However, highest friction factor and lowest heat transfer coefficient were found for SiO2/water nanofluids. The results reveal that, CuO/water nanofluids indicate significant heat transfer performance for helically coiled heat exchanger systems though this nanofluids exhibits higher pressure drop.