A Skate Skin Hydrolysate Restores Cognitive Function in 5XFAD Alzheimer Disease Mice Model by Suppressing Amyloid-β Accumulation via Upregulation of ERK-CREB

Background: The neuroprotective benefits of combined folic acid and docosahexaenoic acid (DHA) on cognitive function in mild cognitive impairment (MCI) patients are suggested but unconfirmed. Objective: To explore the effects of 6-month folic acid + DHA on cognitive function in patients with MCI. Methods: Our randomized controlled trial (trial number ChiCTR-IOR-16008351) was conducted in Tianjin, China. We divided 160 MCI patients aged > 60 years into four regimen groups randomly: folic acid (0.8 mg/day) + DHA (800 mg/day), folic acid (0.8 mg/day), DHA (800 mg/day), and placebo, for 6 months. Cognitive function and blood amyloid-β peptide (Aβ) biomarker levels were measured at baseline and 6 months. Cognitive function was also measured at 12 months. Results: A total of 138 patients completed this trial. Folic acid improved the full-scale intelligence quotient (FSIQ), arithmetic, and picture complement scores; DHA improved the FSIQ, information, arithmetic, and digit span scores; folic acid + DHA improved the arithmetic (difference 1.67, 95% CI 1.02 to 2.31) and digital span (1.33, 0.24 to 2.43) scores compared to placebo. At 12 months, all scores declined in the intervention groups. Folic acid and folic acid + DHA increased blood folate (folic acid + DHA: 7.70, 3.81 to 11.59) and S-adenosylmethionine (23.93, 1.86 to 46.00) levels and reduced homocysteine levels (–6.51, –10.57 to –2.45) compared to placebo. DHA lower the Aβ40 levels (–40.57, –79.79 to –1.35) compared to placebo (p < 0.05), and folic acid + DHA reduced the Aβ42 (–95.59, –150.76 to –40.43) and Aβ40 levels (–45.75, –84.67 to –6.84) more than DHA (p < 0.05). Conclusion: Folic acid and DHA improve cognitive function and reduce blood Aβ production in MCI patients. Combination therapy may be more beneficial in reducing blood Aβ-related biomarkers.

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Neuroprotective Efficacy of Co-Encapsulated Rosiglitazone and Vorinostat Nanoparticle on Streptozotocin Induced Mice Model of Alzheimer Disease

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.1c00022 ◽

2021 ◽

Author(s):

Sarathlal K C ◽

Violina Kakoty ◽

Kowthavarapu Venkata Krishna ◽

Sunil Kumar Dubey ◽

Deepak Chitkara ◽

...

Keyword(s):

Alzheimer Disease ◽

Mice Model ◽

Neuroprotective Efficacy

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Amyloid β-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease

Journal of Neuropathology & Experimental Neurology ◽

10.1097/nen.0b013e3181aed9e6 ◽

2009 ◽

Vol 68 (8) ◽

pp. 857-869 ◽

Cited By ~ 74

Author(s):

Martin A. Bruno ◽

Wanda C. Leon ◽

Gabriela Fragoso ◽

Walter E. Mushynski ◽

Guillermina Almazan ◽

...

Keyword(s):

Nerve Growth Factor ◽

Growth Factor ◽

Alzheimer Disease ◽

Amyloid Β ◽

Nerve Growth

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Lipidated APOE has effects on cognitive function that are independent of amyloid-β pathology

Brain ◽

10.1093/brain/awv300 ◽

2015 ◽

Vol 138 (12) ◽

pp. 3470-3472

Author(s):

Angela Corona ◽

Gary Landreth

Keyword(s):

Cognitive Function ◽

Amyloid Β

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In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2009.10.035 ◽

2010 ◽

Vol 48 (1) ◽

pp. 136-144 ◽

Cited By ~ 122

Author(s):

D. Allan Butterfield ◽

Veronica Galvan ◽

Miranda Bader Lange ◽

Huidong Tang ◽

Renã A. Sowell ◽

...

Keyword(s):

Oxidative Stress ◽

Alzheimer Disease ◽

Transgenic Mice ◽

Amyloid Β ◽

Amyloid Β Peptide ◽

Methionine 35

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Gut Microbiota Alterations and Cognitive Impairment Are Sexually Dissociated in a Transgenic Mice Model of Alzheimer’s Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-201367 ◽

2021 ◽

pp. 1-20

Author(s):

Daniel Cuervo-Zanatta ◽

Jaime Garcia-Mena ◽

Claudia Perez-Cruz

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Gut Microbiota ◽

Cognitive Skills ◽

Amyloid Β ◽

Short Chain Fatty Acids ◽

Mice Model ◽

Model Of Alzheimer’S Disease ◽

Cognitive Deficiencies

Background: Normal aging is accompanied by cognitive deficiencies, affecting women and men equally. Aging is the main risk factor for Alzheimer’s disease (AD), with women having a higher risk. The higher prevalence of AD in women is associated with the abrupt hormonal decline seen after menopause. However, other factors may be involved in this sex-related cognitive decline. Alterations in gut microbiota (GM) and its bioproducts have been reported in AD subjects and transgenic (Tg) mice, having a direct impact on brain amyloid-β pathology in male (M), but not in female (F) mice. Objective: The aim of this work was to determine GM composition and cognitive dysfunction in M and F wildtype (WT) and Tg mice, in a sex/genotype segregation design. Methods: Anxiety, short term working-memory, spatial learning, and long-term spatial memory were evaluated in 6-month-old WT and Tg male mice. Fecal short chain fatty acids were determined by chromatography, and DNA sequencing and bioinformatic analyses were used to determine GM differences. Results: We observed sex-dependent differences in cognitive skills in WT mice, favoring F mice. However, the cognitive advantage of females was lost in Tg mice. GM composition showed few sex-related differences in WT mice. Contrary, Tg-M mice presented a more severe dysbiosis than Tg-F mice. A decreased abundance of Ruminococcaceae was associated with cognitive deficits in Tg-F mice, while butyrate levels were positively associated with better working- and object recognition-memory in WT-F mice. Conclusion: This report describes a sex-dependent association between GM alterations and cognitive impairment in a mice model of AD.

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Correlation between hair zinc level and cognitive function in elderly population

World Nutrition Journal ◽

10.25220/wnj.v03.i2.0008 ◽

2020 ◽

Vol 3 (2) ◽

pp. 59

Author(s):

Dian Sarah Mutiara ◽

Diana Sunardi ◽

Esthika Dewiasty

Keyword(s):

Cognitive Function ◽

Inductively Coupled Plasma ◽

Rank Correlation ◽

Amyloid Β ◽

Cross Sectional Study ◽

Zinc Level ◽

P Value ◽

Hair Zinc ◽

Cross Sectional ◽

The Mean

Introduction: Neurodegenerative disease is the most problem in elderly. Amyloid β (Aβ) accumulation is the major cause of cognitive impairment. Zinc has an important role in antioxidant and Aβ accumulation process. This study aimed to evaluate the correlation between hair zinc level and cognitive function in elderly.Methods: A cross sectional study was conducted involving 58 subjects of elderly in Jakarta. Subjects were recruited by consecutive sampling. Hair zinc level was measured by inductively coupled plasma emission spectrometer (ICPS) and cognitive function assessed by abbreviated mental test (AMT). Data analysis was done by spearman rank correlation test and p-value less than 0.05 were considered statistically significant.Results: The mean of age was 65.4 ± 4.4 years old and 56.9% of subjects were female. The mean of hair zinc level was 123.23 ± 69.71 µg/gram hair and 32.8% subjects had hair zinc deficiency. There was 91.4% subjects had normal cognitive function. The study showed no correlation between hair zinc level and cognitive function in elderly (p=0.871 ; r=-0.022).Conclusions: There was no correlation between hair zinc level and cognitive function in elderly. Further research is expected to be performed with different level of cognitive function.Keywords: cognitive, elderly, hair zinc level, zinc.

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