SRD5A2 gene expression inhibits cell migration and invasion in prostate cancer cell line via F-actin reorganization

2015 ◽  
Vol 408 (1-2) ◽  
pp. 15-23 ◽  
Author(s):  
Suruchi Aggarwal ◽  
Minu Singh ◽  
Ashok Kumar ◽  
Tapas Mukhopadhyay
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Migration ◽  
Cell Line ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Migration And Invasion ◽  
Actin Reorganization ◽  
Srd5a2 Gene

scholarly journals TERF1 downregulation promotes the migration and invasion of the PC3 prostate cancer cell line as a target of miR‑155

2020 ◽  
Vol 22 (6) ◽  
pp. 5209-5218
Author(s):  
Wei Chen ◽  
Li‑Na He ◽  
Yong Liang ◽  
Xiang Zeng ◽  
Cui‑Ping Wu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Migration And Invasion

scholarly journals Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Bianca Cioni ◽  
Anniek Zaalberg ◽  
Judy R. van Beijnum ◽  
Monique H. M. Melis ◽  
Johan van Burgsteden ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Migration And Invasion ◽  
Receptor Signalling

Abstract The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signalling and expression of its downstream cytokines. Moreover, AR signalling in THP-1 and monocyte-derived macrophages upregulates IL-10 and markers of tissue residency. In conclusion, our data suggest that AR signalling in macrophages may support PCa invasiveness, and blocking this process may constitute one mechanism of anti-androgen therapy.

scholarly journals Gene Expression Changes Induced by Genistein in the Prostate Cancer Cell Line LNCaP

2010 ◽  
Vol 3 (1) ◽  
pp. 86-98 ◽  
Author(s):  
Suvarna Bhamre ◽  
Debashis Sahoo ◽  
Robert Tibshirani ◽  
David L. Dill ◽  
James D. Brooks
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line
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