Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice

2014 ◽  
Vol 29 (1) ◽  
pp. 161-165 ◽  
Author(s):  
M. G. Magaji ◽  
M. Mohammed ◽  
R. A. Magaji ◽  
A. M. Musa ◽  
I. Abdu-Aguye ◽  
...  
Keyword(s):  
Bark Extract ◽  
Root Bark ◽  
Aqueous Fraction ◽  
Securinega Virosa

Antipsychotic and sedative effects of residual aqueous fraction of ethanol root bark extract of Carissa edulis (Vahl) in mice

2018 ◽  
Vol 14 (2) ◽  
pp. 113
Author(s):  
Jamilu Ya’u ◽  
Sani Malami ◽  
Zachariah Bako ◽  
Maimouna Moustapha ◽  
Abdullahi H. Yaro
Keyword(s):  
Bark Extract ◽  
Root Bark ◽  
Aqueous Fraction ◽  
Sedative Effects

scholarly journals Evaluation of Anticonvulsant Activity of 80% Methanolic Root Bark Extract and Solvent Fractions of Pentas schimperiana (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Nebeyi Fisseha ◽  
Workineh Shibeshi ◽  
Daniel Bisrat
Keyword(s):  
Anticonvulsant Activity ◽  
Bark Extract ◽  
Anticonvulsant Effect ◽  
Chloroform Fraction ◽  
Therapeutic Effects ◽  
Maximal Electroshock ◽  
Root Bark ◽  
Aqueous Fraction ◽  
Potential Source ◽  
Substantial Morbidity

Background. Epilepsy is one of the most common serious neurological disorders, responsible for substantial morbidity and mortality due to limited efficacy and negative properties of antiepileptic drugs. Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. Pentas schimperiana (A. Rich.) Vatke is a medicinal plant used in Ethiopian traditional medicine for the treatment of epilepsy. However, it lacks scientific investigation on its anticonvulsant activity. Therefore, this study was conducted to evaluate the anticonvulsant activity of 80% methanol root bark extract and solvent fractions of Pentas schimperiana (A. Rich.) Vatke in mice. Methods. Anticonvulsant activity was evaluated by using the pentylenetetrazole and maximal electroshock-induced seizure test. The 80% methanolic root bark extract was subjected to successive fractionation with solvents differing polarity, i.e., chloroform, butanol, and water. The test groups received 100, 200, and 400 mg/kg bodyweight of extract and its solvent fractions. Result. The ME400 and BF400 at the higher dose exhibited a significant ( p < 0.001 ) anticonvulsant effect in both the pentylenetetrazole and maximal electroshock-induced seizure test compared with control. However, chloroform fraction only showed a significant ( p < 0.001 ) anticonvulsant effect in the PTZ-induced seizure test, while aqueous fraction had least anticonvulsant activity in both seizure-induced tests. Phytochemical screening of Pentas schimperiana (A. Rich.) Vatke root bark extract revealed the presence of alkaloids, saponins, flavonoids, phenols, steroids, terpenoids, and tannins. Conclusion. This study indicated that the plant has anticonvulsant activity and is considered as a potential source to develop a new antiepileptic drug.

scholarly journals Securinega virosa (Euphorbiaceae) root bark extract inhibits glioblastoma multiforme cell survival in vitro

2015 ◽  
Vol 9 (27) ◽  
pp. 684-693
Author(s):  
Mohammed Garba Magaji ◽  
Jamilu Yau ◽  
Aliyu Muhammad Musa ◽  
Joseph Akpojo Anuka ◽  
Ibrahim Abdu Aguye ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Survival ◽  
Bark Extract ◽  
Root Bark ◽  
Securinega Virosa

Antidepressant Activity of Ethanol Extract and Residual Aqueous Fraction of Carissa edulis (Apocynaceae) Root Bark in Mice

2017 ◽  
Vol 1 (3) ◽  
pp. 129-132
Author(s):  
Jamilu Ya’u ◽  
◽  
Sani Malami ◽  
Mohammed Abugi ◽  
Hyelnaya Ngura ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Antidepressant Activity ◽  
Root Bark ◽  
Aqueous Fraction

scholarly journals Vascular Protection by Ethanol Extract of Morus alba Root Bark: Endothelium-Dependent Relaxation of Rat Aorta and Decrease of Smooth Muscle Cell Migration and Proliferation

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nisha Panth ◽  
Keshav Raj Paudel ◽  
Dal-Seong Gong ◽  
Min-Ho Oak
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Morus Alba ◽  
Guanosine Monophosphate ◽  
Current Evidence ◽  
Bark Extract ◽  
Root Bark ◽  
Natural Medicine ◽  
And Migration ◽  
Proliferation And Migration

Morus alba (white mulberry) is native to the northern part of Korea and popularly used as a traditional medicine due to its numerous health benefits against human’s disease. However, the possibility that M. alba may also affect the cardiovascular system remains unexplored. This study sought to investigate the vascular protective effects of the root bark extract of M. alba (MAE). Vascular reactivity was performed in organ baths using isolated rat thoracic aorta, while platelet derived growth factor (PDGF) induced proliferation and migration of vascular smooth muscle cells (VSMCs) were studied by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and wound healing assay, respectively. MAE evoked a concentration dependent vasorelaxation following endothelium-dependent pathway. However, vessel relaxations in response to MAE were markedly reduced after endothelium removal; treatment of endothelial nitric oxide synthase inhibitor, guanylyl cyclase inhibitor, and nonspecific potassium channel inhibitor, however, was not altered by cyclooxygenase inhibitor. Furthermore, MAE also significantly blunted contractile response to vasoconstrictor agent, phenylephrine. Taken together, the current evidence revealed that MAE is a potent endothelium-dependent vasodilator and this effect was involved in, at least in part, nitric oxide cyclic-guanosine monophosphate (NO-cGMP) pathway in combination with potassium (K+) channel activation. Moreover, MAE inhibited proliferation and migration of VSMCs induced by PDGF. Therefore, MAE could be a promising candidate of natural medicine for preventing and controlling cardiovascular diseases linked with endothelial dysfunction.

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