Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats

Background: 3,4,5-Trihydroxybenzoic acid, which is also known as gallic acid, is an anti-inflammatory agent who could provide beneficial effects in preventing periodontal inflammation. The present study aimed to evaluate the anti-inflammatory effects of gallic acid on experimental periodontitis in Wistar rats. Alveolar bone loss, osteoclastic activity, osteoblastic activity, and collagenase activity were also determined. Methods: 32 Wistar rats were used in the present study. Study groups were created as following: Healthy control (C,n=8) group; periodontitis (P,n=8) group; periodontitis and 30 mg/kg gallic acid administered group (G30,n=8); periodontitis and 60 mg/kg gallic acid administered group (G60,n=8). Experimental periodontitis was created by placing 4-0 silk sutures around the mandibular right first molar tooth. Morphological changes in alveolar bone were determined by stereomicroscopic evaluation. Mandibles were undergone histological evaluation. Matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1, bone morphogenetic protein (BMP)-2 expressions, tartrate-resistant acid phosphatase (TRAP) positive osteoclast cells, osteoblast, and inflammatory cell counts were determined. Results: Highest alveolar bone loss was observed in the periodontitis group. Both doses of gallic acid decreased alveolar bone loss compared to the P group. TRAP-positive osteoclast cell counts were higher in the P group, and gallic acid successfully lowered these counts. Osteoblast cells also increased in gallic acid administered groups. Inflammation in the P group was also higher than those of C, G30, and G60 groups supporting the role of gallic acid in preventing inflammation. 30 and 60 mg/kg doses of gallic acid decreased MMP-8 levels and increased TIMP-1 levels. BMP levels increased in gallic acid administered groups, similar to several osteoblasts. Conclusion: Present results revealed an anti-inflammatory effect of gallic acid, which was indicated by decreased alveolar bone loss and collagenase activity and increased osteoblastic activity.

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Ginkgo biloba mitigates silver nanoparticles-induced hepatotoxicity in Wistar rats via improvement of mitochondrial biogenesis and antioxidant status

Environmental Science and Pollution Research ◽

10.1007/s11356-019-05835-2 ◽

2019 ◽

Vol 26 (25) ◽

pp. 25844-25854 ◽

Cited By ~ 4

Author(s):

Eman M. Abd El-Maksoud ◽

Mohamed A. Lebda ◽

Aml E. Hashem ◽

Nabil M. Taha ◽

Maher A. Kamel

Keyword(s):

Silver Nanoparticles ◽

Mitochondrial Biogenesis ◽

Ginkgo Biloba ◽

Antioxidant Status ◽

Wistar Rats

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Effect of gallic acid on xenobiotic metabolizing enzymes in 1,2-dimethyl hydrazine induced colon carcinogenesis in Wistar rats – A chemopreventive approach

Food and Chemical Toxicology ◽

10.1016/j.fct.2010.12.012 ◽

2011 ◽

Vol 49 (4) ◽

pp. 887-892 ◽

Cited By ~ 29

Author(s):

J. Giftson Senapathy ◽

S. Jayanthi ◽

P. Viswanathan ◽

P. Umadevi ◽

N. Nalini

Keyword(s):

Gallic Acid ◽

Wistar Rats ◽

Colon Carcinogenesis ◽

Metabolizing Enzymes ◽

Xenobiotic Metabolizing Enzymes

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Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

Journal of Biomedical Sciencies ◽

10.4172/2254-609x.100071 ◽

2017 ◽

Vol 06 (04) ◽

Cited By ~ 3

Author(s):

Serah Funke Ige ◽

Mayowa Jeremiah Adeniyi ◽

Grace Oladuuni Iyalla

Keyword(s):

Allium Cepa ◽

Aluminum Chloride ◽

Wistar Rats ◽

Male Wistar Rats

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Antioxidant status and hepato-protective role of Anchomanes difformis in streptozotocin-induced diabetes in male Wistar rats

Herba Polonica ◽

10.2478/hepo-2020-0005 ◽

2020 ◽

Vol 66 (1) ◽

pp. 18-36

Author(s):

Toyin D. Alabi ◽

Nicole L. Brooks ◽

Oluwafemi O. Oguntibeju

Keyword(s):

Type 2 Diabetes ◽

Blood Glucose ◽

Aqueous Extract ◽

Liver Dysfunction ◽

Antioxidant Status ◽

Wistar Rats ◽

Serum Levels ◽

Male Wistar Rats ◽

Hepatic Injuries

SummaryIntroduction: The liver is involved in the metabolism of xenobiotics and their metabolites and it is vulnerable to oxidative damage. Hyperglycaemia is highly implicated in the progression of diabetes mellitus, and adversely affects the liver. Though, conventional hypoglycaemic drugs may be effective in reducing blood glucose, they do not appear to be effective in attenuating the progression of diabetes and its complications.Objective: This study evaluated the ameliorative effects of Anchomanes difformis on hyperglycaemia and hepatic injuries in type 2 diabetes.Methods: Type 2 diabetes was induced in male Wistar rats with a single intraperitoneal injection of streptozotocin (40 mg/kg BW) after two weeks of fructose (10%) administration. Aqueous extract of A. difformis (200 and 400 mg/kg BW) and glibenclamide (5 mg/kg BW) were administered orally for six weeks. Blood glucose concentrations were measured. Serum levels of liver dysfunction markers (ALT, AST, and ALP), total cholesterol, triglycerides, HDL- and LDL-cholesterol were investigated. Total protein, albumin, and globulin were also assessed. Antioxidant parameters: ORAC, GSH, GSSG, SOD, CAT and FRAP were evaluated in the liver while ORAC, FRAP and lipid peroxidation were determined in the serum. Histological examination of the liver tissue was carried out.Results: Treatment with aqueous extract of A. difformis significantly (p<0.05) reduced blood glucose and reversed steatosis in the diabetic-treated rats. The antioxidant status of diabetic-treated rats was significantly (p<0.05) improved. Serum levels of liver dysfunction markers were significantly (p<0.05) reduced in diabetic-treated rats.Conclusion: The findings in this study revealed that 400 mg/kgBW Anchomanes difformis was more effective than 200 mg/kg BW in ameliorating diabetes-induced hepatopathy, however, both doses of Anchomanes difformis demonstrated more antidiabetic ability than glibenclamide. Anchomanes difformis may be a novel and potential therapeutic agent in the management of diabetes and resulted hepatic injuries.

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