DNA microarray analysis reveals differential gene expression in the soleus muscle between male and female rats exposed to a high fat diet

2012 ◽  
Vol 39 (6) ◽  
pp. 6569-6580 ◽  
Author(s):  
Tae Seok Oh ◽  
Jong Won Yun
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Microarray Analysis ◽  
Dna Microarray ◽  
High Fat Diet ◽  
Female Rats ◽  
High Fat ◽  
Male And Female ◽  
Male And Female Rats ◽  
Differential Gene

scholarly journals Effects of Diet-Induced Obesity on Hypothalamic Kisspeptin-Neurokinin-Dynorphin (KNDy) Neurons and Luteinizing Hormone Secretion in Sex Hormone-Primed Male and Female Rats

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A537-A537
Author(s):  
Shiori Minabe ◽  
Kinuyo Iwata ◽  
Hitoshi Ozawa
Keyword(s):  
Gene Expression ◽  
Luteinizing Hormone ◽  
High Fat Diet ◽  
Female Rats ◽  
Male Rats ◽  
High Fat ◽  
Neurokinin B ◽  
Male And Female ◽  
Male And Female Rats ◽  
Kndy Neurons

Abstract Metabolic stress resulting from a nutrient excess causes infertility in both sexes. Kisspeptin-neurokinin B-dynorphin (KNDy) neurons in the arcuate nucleus (ARC) have been suggested to be key players in reproduction via direct stimulation of gonadotropin-releasing hormone (GnRH) and subsequent gonadotropin release in mammalian species. In this study, we investigated the sex differences in the effects of a high-fat diet (HFD) on KNDy-associated gene expression in the ARC to determine the pathogenic mechanism underlying obesity-induced infertility. Wistar-Imamichi strain male and female rats (7 weeks of age) were fed either a standard diet (10% calories from fat) or high-fat diet (45% calories from fat) for 4 months. In male rats, the HFD caused a significant suppression of Kiss1(encoding kisspeptin), Tac3(encoding neurokinin B), and Pdyn(encoding dynorphin A) gene expression in the ARC, resulting in a decrease in plasma luteinizing hormone (LH) levels. In female rats, 58% of the HFD-fed female rats exhibited irregular estrous cycles, while the other rats showed regular cycles. LH pulses were found, and the numbers of ARC Kiss1-,Tac3-, and Pdyn-expressing cells were high in control animals and almost allHFD-fed female rats, but two out of 10 rats showed profound HFD-induced suppression of LH pulse frequency and reduction in these cells. No statistical differences in LH secretion or ARC KNDy gene expression were observed between HFD-fed and control female rats. Additionally, the number of Gnrh1-expressing cells in the preoptic area was comparable between the groups in both sexes. Our findings revealed that HFD-fed male rats showed KNDy-dependent infertility, while irregular menstruation was mainly induced by KNDy-independent pathways during the incipient stage of obese infertility in female rats. Taken together, hypothalamic kisspeptin neurons in male rats may be susceptible to HFD-induced obesity compared with those in female rats.

Differential Gene Expression of Organic Anion Transporters in Male and Female Rats

2002 ◽  
Vol 290 (1) ◽  
pp. 482-487 ◽  
Author(s):  
Yasuna Kobayashi ◽  
Noriko Hirokawa ◽  
Naomi Ohshiro ◽  
Takashi Sekine ◽  
Tadanori Sasaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Organic Anion ◽  
Female Rats ◽  
Organic Anion Transporters ◽  
Male And Female ◽  
Anion Transporters ◽  
Male And Female Rats ◽  
Differential Gene

scholarly journals Differential gene expression in trigeminal ganglia of male and female rats following chronic constriction of the infraorbital nerve

2018 ◽  
Vol 22 (5) ◽  
pp. 875-888 ◽  
Author(s):  
O.A. Korczeniewska ◽  
S. Husain ◽  
J. Khan ◽  
E. Eliav ◽  
P. Soteropoulos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Female Rats ◽  
Infraorbital Nerve ◽  
Trigeminal Ganglia ◽  
Male And Female ◽  
Male And Female Rats ◽  
Differential Gene

scholarly journals Long-term High-fat-diet Feeding Impairs Mitochondrial Biogenesis in Liver of Male and Female Rats

2010 ◽  
Vol 26 (3) ◽  
pp. 291-302 ◽  
Author(s):  
Antònia Nadal-Casellas ◽  
Emilia Amengual-Cladera ◽  
Ana María Proenza ◽  
Isabel Lladó ◽  
Magdalena Gianotti
Keyword(s):  
Mitochondrial Biogenesis ◽  
High Fat Diet ◽  
Female Rats ◽  
High Fat ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine D1 Receptor Agonist SKF 82958

2020 ◽  
Vol 374 (1) ◽  
pp. 6-15
Author(s):  
Jeremiah Ramos ◽  
Ethan J. Hardin ◽  
Alice H. Grant ◽  
Grace Flores-Robles ◽  
Adrian T. Gonzalez ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Receptor Agonist ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Female Rats ◽  
High Fat ◽  
Male And Female ◽  
Male And Female Rats ◽  
Skf 82958
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