Differential Gene Expression of Organic Anion Transporters in Male and Female Rats

2002 ◽  
Vol 290 (1) ◽  
pp. 482-487 ◽  
Author(s):  
Yasuna Kobayashi ◽  
Noriko Hirokawa ◽  
Naomi Ohshiro ◽  
Takashi Sekine ◽  
Tadanori Sasaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Organic Anion ◽  
Female Rats ◽  
Organic Anion Transporters ◽  
Male And Female ◽  
Anion Transporters ◽  
Male And Female Rats ◽  
Differential Gene

scholarly journals Differential gene expression in trigeminal ganglia of male and female rats following chronic constriction of the infraorbital nerve

2018 ◽  
Vol 22 (5) ◽  
pp. 875-888 ◽  
Author(s):  
O.A. Korczeniewska ◽  
S. Husain ◽  
J. Khan ◽  
E. Eliav ◽  
P. Soteropoulos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Female Rats ◽  
Infraorbital Nerve ◽  
Trigeminal Ganglia ◽  
Male And Female ◽  
Male And Female Rats ◽  
Differential Gene

scholarly journals Analysis of structure and gene expression in developing kidneys of male and female rats exposed to low protein diets in utero

2020 ◽  
Vol 303 (10) ◽  
pp. 2657-2667 ◽  
Author(s):  
Ryan J. Wood‐Bradley ◽  
Sarah L. Henry ◽  
Sanna Barrand ◽  
Anais Giot ◽  
Luke Eipper ◽  
...  
Keyword(s):  
Gene Expression ◽  
In Utero ◽  
Female Rats ◽  
Male And Female ◽  
Low Protein ◽  
Male And Female Rats ◽  
Protein Diets

scholarly journals Gene expression within the periaqueductal gray is linked to vocal behavior and early-onset parkinsonism in Pink1 knockout rats

BMC Genomics ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Cynthia A. Kelm-Nelson ◽  
Stephen Gammie
Keyword(s):  
Gene Expression ◽  
Early Onset ◽  
Early Stage ◽  
Protein Localization ◽  
Periaqueductal Gray ◽  
Female Rats ◽  
Vocal Behavior ◽  
Metabotropic Receptors ◽  
Male And Female ◽  
Male And Female Rats

Abstract Background Parkinson’s disease (PD) is a degenerative disease with early-stage pathology hypothesized to manifest in brainstem regions. Vocal deficits, including soft, monotone speech, result in significant clinical and quality of life issues and are present in 90% of PD patients; yet the underlying pathology mediating these significant voice deficits is unknown. The Pink1−/− rat is a valid model of early-onset PD that presents with analogous vocal communication deficits. Previous work shows abnormal α-synuclein protein aggregation in the periaqueductal gray (PAG), a brain region critical and necessary to the modulation of mammalian vocal behavior. In this study, we used high-throughput RNA sequencing to examine gene expression within the PAG of both male and female Pink1−/− rats as compared to age-matched wildtype controls. We used a bioinformatic approach to (1) test the hypothesis that loss of Pink1 in the PAG will influence the differential expression of genes that interact with Pink1, (2) highlight other key genes that relate to this type of Mendelian PD, and (3) catalog molecular targets that may be important for the production of rat vocalizations. Results Knockout of the Pink1 gene resulted in differentially expressed genes for both male and female rats that also mapped to human PD datasets. Pathway analysis highlighted several significant metabolic pathways. Weighted gene co-expression network analysis (WGCNA) was used to identify gene nodes and their interactions in (A) males, (B) females, and (C) combined-sexes datasets. For each analysis, within the module containing the Pink1 gene, Pink1 itself was the central node with the highest number of interactions with other genes including solute carriers, glutamate metabotropic receptors, and genes associated with protein localization. Strong connections between Pink1 and Krt2 and Hfe were found in both males and female datasets. In females a number of modules were significantly correlated with vocalization traits. Conclusions Overall, this work supports the premise that gene expression changes in the PAG may contribute to the vocal deficits observed in this PD rat model. Additionally, this dataset identifies genes that represent new therapeutic targets for PD voice disorders.

Chronic alcohol feeding and its influence on c-Fos and heat shock protein-70 gene expression in different brain regions of male and female rats

Metabolism ◽  
2002 ◽  
Vol 51 (12) ◽  
pp. 1562-1568 ◽  
Author(s):  
Tatsuo Nakahara ◽  
Makoto Hirano ◽  
Hideyuki Uchimura ◽  
Sima Shirali ◽  
Colin R. Martin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Brain Regions ◽  
Female Rats ◽  
Chronic Alcohol ◽  
Male And Female ◽  
Male And Female Rats

Mammary gland morphology and gene expression signature of weanling male and female rats following exposure to exogenous estradiol

2013 ◽  
Vol 238 (9) ◽  
pp. 1033-1046 ◽  
Author(s):  
Isabelle R Miousse ◽  
Horacio Gomez-Acevedo ◽  
Neha Sharma ◽  
Jamie Vantrease ◽  
Leah Hennings ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mammary Gland ◽  
Gene Expression Signature ◽  
Female Rats ◽  
Male And Female ◽  
Expression Signature ◽  
Male And Female Rats ◽  
Mammary Gland Morphology
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