scholarly journals Synergistic effect of metformin and vemurufenib (PLX4032) as a molecular targeted therapy in anaplastic thyroid cancer: an in vitro study

2021 ◽  
Author(s):  
Latha Durai ◽  
Soundharya Ravindran ◽  
Krishnamurthy Arvind ◽  
Devarajan Karunagaran ◽  
Ramshankar Vijayalakshmi
Keyword(s):  
Thyroid Cancer ◽  
Targeted Therapy ◽  
Synergistic Effect ◽  
Molecular Targeted Therapy ◽  
In Vitro Study ◽  
Anaplastic Thyroid Cancer ◽  
Vitro Study

scholarly journals Cytokine Production by a New Undifferentiated Human Thyroid Carcinoma Cell Line, FB-11

1997 ◽  
Vol 82 (12) ◽  
pp. 4094-4100
Author(s):  
Lisa Fiore ◽  
Luca E. Pollina ◽  
Gabriella Fontanini ◽  
Rosario Casalone ◽  
Maria T. Berlingieri ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Line ◽  
Messenger Rna ◽  
Thyroid Tissue ◽  
Cancer Cell Line ◽  
In Vitro Study ◽  
Anaplastic Thyroid Cancer ◽  
Human Thyroid ◽  
Immunodeficient Mice

A human anaplastic thyroid cancer cell line FB-1, derived from a 68-yr-old woman who underwent surgery for anaplastic thyroid cancer, has been established. The spindlelike cells have been proliferating stably for more than 2 yr. Karyotype analysis shows many abnormalities and many marker chromosomes have been observed. Heterotransplant of FB-1 cells into severe combined immunodeficient mice has resulted in rapidly growing tumors classified as anaplastic carcinomas, although 50% have shown areas with a trabecular pattern. FB-1 cells failed to express messenger RNA for thyroglobulin; TSH-receptor; thyroperoxidase, and placental angiogenic growth factor. Conversely, PAX8 and thyroid transcription factor 1, whose expression is thyroid specific, was kept in an FB-1 cell line at a level comparable with that observed in normal thyroid tissue. In addition, the present cell line expressed high levels of messenger RNA for high-mobility group proteins (Y) and -C. The in vitro study revealed that FB-1 cells are able to produce high levels of interleukin (IL)-8 and medium amount of IL-6, whereas no release of IL-1-α, IL-1-β, and IL-4 was observed. No modulation of cell proliferation and DNA synthesis in FB-1 cells has been observed after the addition of exogenous IL-6.

scholarly journals Synergistic Effect of Arginine on Remineralization Potential of Fluoride Varnish and Nanohydroxyapatite on Artificial Caries Lesions: An In Vitro Study

2020 ◽  
Vol 21 (9) ◽  
pp. 1048-1053
Author(s):  
Ravi K Konagala ◽  
Jyothi Mandava ◽  
Anupreeta Anwarullah ◽  
Lakshman V Uppalapati ◽  
Srujana Karumuri ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
In Vitro Study ◽  
Vitro Study ◽  
Fluoride Varnish ◽  
Caries Lesions

scholarly journals Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study

Odontology ◽  
2021 ◽  
Author(s):  
Özge Özdal Zincir ◽  
Umut Özdal ◽  
Özge Ünlü ◽  
Mehmet Demirci ◽  
Ahmet Bülent Katiboğlu ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Oral Candidiasis ◽  
In Vitro Study ◽  
Vitro Study

Synergistic Effect of Er:YAG Laser Irradiation in Combination with Chlorhexidine on the Viability of Enterococcus faecalis: An In Vitro Study

2011 ◽  
Vol 29 (11) ◽  
pp. 753-758 ◽  
Author(s):  
Sharonit Sahar-Helft ◽  
Iris Slutzky-Goldberg ◽  
Joshua Moshonov ◽  
Adam Stabholtz ◽  
Marcos Jacobovitz ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Laser Irradiation ◽  
Enterococcus Faecalis ◽  
Er:Yag Laser ◽  
In Vitro Study ◽  
Vitro Study
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