The Serotonin System in Mammalian Oogenesis

2022 ◽  
Author(s):  
Yu. B. Shmukler ◽  
N. M. Alyoshina ◽  
L. A. Malchenko ◽  
D. A. Nikishin
Keyword(s):  
Serotonin System

Intact Brain Serotonin System in Vascular Dementia

1996 ◽  
Vol 7 (4) ◽  
pp. 196-200
Author(s):  
Gunilla Hansson ◽  
Irina Alafuzoff ◽  
Bengt Winblad ◽  
Jan Marcusson
Keyword(s):  
Vascular Dementia ◽  
Brain Serotonin ◽  
Serotonin System ◽  
Intact Brain

scholarly journals Alterations in BDNF Protein Concentrations in the Hippocampus do not Explain the Pro-Neurogenic Effect of Citalopram on Adult Neurogenesis

2020 ◽  
Author(s):  
Markus Petermann ◽  
Golo Kronenberg ◽  
Valentina Mosienko ◽  
Michael Bader ◽  
Natalia Alenina ◽  
...  
Keyword(s):  
Cell Survival ◽  
Mechanism Of Action ◽  
Adult Neurogenesis ◽  
Neurotrophic Factor ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Daily Injection ◽  
Wild Type ◽  
Protein Levels ◽  
Serotonin System ◽  
Antidepressant Pharmacotherapy

Abstract Introduction Brain-derived neurotrophic factor (BDNF) has been implicated in the pro-neurogenic effect of selective serotonin reuptake inhibitors. In this study, we used Tph2 −/− mice lacking brain serotonin to dissect the interplay between BDNF and the serotonin system in mediating the effects of antidepressant pharmacotherapy on adult neurogenesis in the hippocampus. Methods Besides citalopram (CIT), we tested tianeptine (TIA), an antidepressant whose mechanism of action is not well understood. Specifically, we examined cell survival and endogenous concentrations of BDNF following daily injection of the drugs. Results Twenty-one days of CIT, but not of TIA, led to a significant increase in the survival of newly generated cells in the dentate gyrus of wild-type mice, without a significant effect on BDNF protein levels by either treatment. In Tph2 −/− mice, adult neurogenesis was consistently increased. Furthermore, Tph2 −/− mice showed increased BDNF protein levels, which were not affected by TIA but were significantly reduced by CIT. Discussion We conclude that the effects of CIT on adult neurogenesis are not explained by changes in BDNF protein concentrations in the hippocampus.

Serotonin transporter is not required for the development of severe pulmonary hypertension in the Sugen hypoxia rat model

2015 ◽  
Vol 309 (10) ◽  
pp. L1164-L1173 ◽  
Author(s):  
Michiel Alexander de Raaf ◽  
Yvet Kroeze ◽  
Anthonieke Middelman ◽  
Frances S. de Man ◽  
Helma de Jong ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Serotonin Transporter ◽  
Rat Model ◽  
Systolic Pressure ◽  
Serum Levels ◽  
Normal Function ◽  
Ventricular Systolic Pressure ◽  
Serotonin System ◽  
Pulmonary Arterial

Increased serotonin serum levels have been proposed to play a key role in pulmonary arterial hypertension (PAH) by regulating vessel tone and vascular smooth muscle cell proliferation. An intact serotonin system, which critically depends on a normal function of the serotonin transporter (SERT), is required for the development of experimental pulmonary hypertension in rodents exposed to hypoxia or monocrotaline. While these animal models resemble human PAH only with respect to vascular media remodeling, we hypothesized that SERT is likewise required for the presence of lumen-obliterating intima remodeling, a hallmark of human PAH reproduced in the Sugen hypoxia (SuHx) rat model of severe angioproliferative pulmonary hypertension. Therefore, SERT wild-type (WT) and knockout (KO) rats were exposed to the SuHx protocol. SERT KO rats, while completely lacking SERT, were hemodynamically indistinguishable from WT rats. After exposure to SuHx, similar degrees of severe angioproliferative pulmonary hypertension and right ventricular hypertrophy developed in WT and KO rats (right ventricular systolic pressure 60 vs. 55 mmHg, intima thickness 38 vs. 30%, respectively). In conclusion, despite its implicated importance in PAH, SERT does not play an essential role in the pathogenesis of severe angioobliterative pulmonary hypertension in rats exposed to SuHx.

scholarly journals A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System

2016 ◽  
Vol 37 (1) ◽  
pp. 120-128 ◽  
Author(s):  
Vincent Beliveau ◽  
Melanie Ganz ◽  
Ling Feng ◽  
Brice Ozenne ◽  
Liselotte Højgaard ◽  
...  
Keyword(s):  
High Resolution ◽  
Serotonin System

The effect of dietary fat on diet selection may involve central serotonin

1992 ◽  
Vol 263 (3) ◽  
pp. R559-R563 ◽  
Author(s):  
B. J. Mullen ◽  
R. J. Martin
Keyword(s):  
Food Intake ◽  
Dietary Fat ◽  
Corn Oil ◽  
Serum Insulin ◽  
Diet Selection ◽  
Potential Mechanism ◽  
Serotonin System ◽  
Selection Behavior ◽  
Brain Tissues

Rats consuming a diet of 34% tallow select more protein and less carbohydrate than rats fed either 5% corn oil or tallow or 34% corn oil (25). To examine potential mechanism(s) of this phenomenon, we fed rats diets containing either tallow or corn oil at levels of 5 or 34% for 2 days. Sera were analyzed, and rats fed 34% tallow had higher serum insulin compared with those fed 34% corn oil. In a second experiment, rats were fed either 34% corn oil or tallow for 2 days. Brain tissues were analyzed, and rats fed 34% tallow had elevated serotonin in the raphe area compared with those fed 34% corn oil. In a third experiment, rats were fed either 34% corn oil or tallow for 2 days and then given dl-fenfluramine before diet selection. Fenfluramine depressed food intake to a greater degree in rats fed 34% tallow compared with those fed corn oil. These findings suggest that the diet selection behavior observed in tallow-fed rats may be mediated by a central serotonin system.

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