Enhancement of pituitary adenoma cell invasion and adhesion is mediated by discoidin domain receptor-1

2006 ◽  
Vol 82 (1) ◽  
pp. 29-40 ◽  
Author(s):  
Daizo Yoshida ◽  
Akira Teramoto
Keyword(s):  
Pituitary Adenoma ◽  
Cell Invasion ◽  
Discoidin Domain Receptor ◽  
Adenoma Cell ◽  
Discoidin Domain Receptor 1

scholarly journals Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42–Tuba pathway

2014 ◽  
Vol 207 (4) ◽  
pp. 517-533 ◽  
Author(s):  
Amélie Juin ◽  
Julie Di Martino ◽  
Birgit Leitinger ◽  
Elodie Henriet ◽  
Anne-Sophie Gary ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Type I Collagen ◽  
Type I ◽  
Dependent Manner ◽  
Nucleotide Exchange ◽  
Independent Manner ◽  
Src Tyrosine Kinase ◽  
Discoidin Domain Receptor ◽  
Increased Risk ◽  
Discoidin Domain Receptor 1

Accumulation of type I collagen fibrils in tumors is associated with an increased risk of metastasis. Invadosomes are F-actin structures able to degrade the extracellular matrix. We previously found that collagen I fibrils induced the formation of peculiar linear invadosomes in an unexpected integrin-independent manner. Here, we show that Discoidin Domain Receptor 1 (DDR1), a collagen receptor overexpressed in cancer, colocalizes with linear invadosomes in tumor cells and is required for their formation and matrix degradation ability. Unexpectedly, DDR1 kinase activity is not required for invadosome formation or activity, nor is Src tyrosine kinase. We show that the RhoGTPase Cdc42 is activated on collagen in a DDR1-dependent manner. Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation. Finally, DDR1 depletion blocked cell invasion in a collagen gel. Altogether, our data uncover an important role for DDR1, acting through Tuba and Cdc42, in proteolysis-based cell invasion in a collagen-rich environment.

Discoidin Domain Receptor-1a (DDR1a) Promotes Glioma Cell Invasion and Adhesion in Association with Matrix Metalloproteinase-2

2005 ◽  
Vol 76 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Rosalyn Ram ◽  
Gustavo Lorente ◽  
Karoly Nikolich ◽  
Roman Urfer ◽  
Erik Foehr ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Cell Invasion ◽  
Glioma Cell ◽  
Matrix Metalloproteinase 2 ◽  
Discoidin Domain Receptor
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