Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest

2012 ◽  
Vol 108 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Zhiqiang Xu ◽  
Neel Joshi ◽  
Ashima Agarwal ◽  
Sonika Dahiya ◽  
Patrice Bittner ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Nucleolin Expression

scholarly journals  -Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth

2011 ◽  
Vol 33 (2) ◽  
pp. 413-419 ◽  
Author(s):  
J. J. Johnson ◽  
S. M. Petiwala ◽  
D. N. Syed ◽  
J. T. Rasmussen ◽  
V. M. Adhami ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Xenograft Tumor ◽  
Cycle Arrest ◽  
Xenograft Tumor Growth

scholarly journals A Novel Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest via p27 Stabilization

2008 ◽  
Vol 283 (17) ◽  
pp. 11565-11574 ◽  
Author(s):  
Chunmei Wang ◽  
Nan Li ◽  
Xingguang Liu ◽  
Yuanyuan Zheng ◽  
Xuetao Cao
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Inhibitory Protein ◽  
Cycle Arrest

scholarly journals New pyrazolo‐[3,4‐ d ]‐pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells

2010 ◽  
Vol 24 (8) ◽  
pp. 2881-2892 ◽  
Author(s):  
Alessandra Rossi ◽  
Silvia Schenone ◽  
Adriano Angelucci ◽  
Martina Cozzi ◽  
Valentina Caracciolo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Kinase Inhibitors ◽  
Src Kinase ◽  
Pyrimidine Derivative ◽  
Growth Reduction ◽  
Cycle Arrest ◽  
Human Medulloblastoma

scholarly journals Mangrove dolabrane‐type of diterpenes tagalsins suppresses tumor growth via ROS ‐mediated apoptosis and ATM/ATR–C hk1/Chk2‐regulated cell cycle arrest

2015 ◽  
Vol 137 (11) ◽  
pp. 2739-2748 ◽  
Author(s):  
Jennifer Neumann ◽  
Yi Yang ◽  
Rebecca Köhler ◽  
Marco Giaisi ◽  
Mathias Witzens‐Harig ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Cycle Arrest

scholarly journals Clove Extract Inhibits Tumor Growth and Promotes Cell Cycle Arrest and Apoptosis

2014 ◽  
Vol 21 (5) ◽  
pp. 247-259 ◽  
Author(s):  
Haizhou Liu ◽  
John C. Schmitz ◽  
Jianteng Wei ◽  
Shousong Cao ◽  
Jan H. Beumer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Clove Extract

The Zn(S-pr-thiosal)2 complex attenuates murine breast cancer growth by inducing apoptosis and G1/S cell cycle arrest

2020 ◽  
Vol 12 (10) ◽  
pp. 897-914
Author(s):  
Sasa Benazic ◽  
Zana Besser Silconi ◽  
Andra Jevtovic ◽  
Milena Jurisevic ◽  
Jelena Milovanovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Tumor Growth ◽  
Cell Cycle Arrest ◽  
Cell Cycle Progression ◽  
Cyclin D3 ◽  
Antitumor Effects ◽  
Cycle Arrest ◽  
4T1 Cells

Aim: We investigated the antitumor effects of zinc(II) complex with S-propyl thiosalicylic acid [Zn( S-pr-thiosal)2] in 4T1 murine breast cancer model. Results: The Zn( S-pr-thiosal)2 complex reduced primary tumor growth in vivo and induced tumor cell apoptosis. The Zn( S-pr-thiosal)2 complex disrupted the balance between pro- and antiapoptotic Bcl-2 family members in 4T1 cells and induced G1/S cell cycle arrest. The Zn( S-pr-thiosal)2 complex increased the percentage of p16, p21 and p27 positive 4T1 cells. There was a significantly decrease in expression of STAT3 and its targets c-Myc and cyclin D3 in 4T1 cells treated with the Zn( S-pr-thiosal)2 complex thus contributing to G1/S cell cycle arrest and/or apoptosis. Conclusion: Our data suggest that the Zn( S-pr-thiosal)2 complex restricted tumor growth through induction of mitochondrial-driven apoptosis and suppression of cell cycle progression.

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