Improvement of Hypoxia–Ischemia-Induced White Matter Injury in Immature Rat Brain by Ethyl Pyruvate

2013 ◽  
Vol 38 (4) ◽  
pp. 742-752 ◽  
Author(s):  
Yingyan Wang ◽  
Baomin Li ◽  
Zhen Li ◽  
Shanying Huang ◽  
Jiwen Wang ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Ethyl Pyruvate ◽  
White Matter Injury ◽  
Immature Rat ◽  
Hypoxia Ischemia

Ethyl pyruvate protects against lipopolysaccharide‐induced white matter injury in the developing rat brain

2012 ◽  
Vol 31 (3) ◽  
pp. 181-188 ◽  
Author(s):  
Wang Yingyan ◽  
Yin Ping ◽  
Huang Shanying ◽  
Wang Jiwen ◽  
Sun Ruopeng
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Ethyl Pyruvate ◽  
White Matter Injury ◽  
Developing Rat

Activated protein C reduces endotoxin-induced white matter injury in the developing rat brain

2007 ◽  
Vol 1164 ◽  
pp. 14-23 ◽  
Author(s):  
Didem Cemile Yesilirmak ◽  
Abdullah Kumral ◽  
Huseyin Baskin ◽  
Bekir Ugur Ergur ◽  
Simge Aykan ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Protein C ◽  
Activated Protein C ◽  
White Matter Injury ◽  
Developing Rat

Topographical and quantitative assessment of white matter injury following a focal ischaemic lesion in the rat brain

1998 ◽  
Vol 2 (4) ◽  
pp. 315-322 ◽  
Author(s):  
P.S Yam ◽  
J Patterson ◽  
D.I Graham ◽  
T Takasago ◽  
D Dewar ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Quantitative Assessment ◽  
White Matter Injury ◽  
Ischaemic Lesion

scholarly journals Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain

2005 ◽  
Vol 373 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Eszter Farkas ◽  
Anita Annaházi ◽  
Ádám Institóris ◽  
András Mihály ◽  
Paul G.M. Luiten ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Dimethyl Sulphoxide ◽  
White Matter Injury ◽  
Cerebral Hypoperfusion

scholarly journals Effects of Hypoxia-Ischemia on GLUT1 and GLUT3 Glucose Transporters in Immature Rat Brain

1996 ◽  
Vol 16 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Susan J. Vannucci ◽  
Lisa B. Seaman ◽  
Robert C. Vannucci
Keyword(s):  
Rat Brain ◽  
Glucose Transporter ◽  
Recovery Period ◽  
Neuronal Loss ◽  
Cerebral Hypoxia ◽  
Immature Rat ◽  
Transporter Proteins ◽  
Unilateral Brain Damage ◽  
Hypoxia Ischemia ◽  
Glucose Transporter Proteins

Cerebral hypoxia-ischemia produces major alterations in energy metabolism and glucose utilization in brain. The facilitative glucose transporter proteins mediate the transport of glucose across the blood–brain barrier (BBB) (55 kDa GLUT1) and into the neurons and glia (GLUT3 and 45 kDa GLUT1). Glucose uptake and utilization are low in the immature rat brain, as are the levels of the glucose transporter proteins. This study investigated the effect of cerebral hypoxia-ischemia in a model of unilateral brain damage on the expression of GLUT 1 and GLUT3 in the ipsilateral (damaged, hypoxic-ischemic) and contralateral (undamaged, hypoxic) hemispheres of perinatal rat brain. Early in the recovery period, both hemispheres exhibited increased expression of BBB GLUT1 and GLUT3, consistent with increased glucose transport and utilization. Further into recovery, BBB GLUT1 increased and neuronal GLUT3 decreased in the damaged hemisphere only, commensurate with neuronal loss.

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