The Effects of Incensole Acetate on Neuro-inflammation, Brain-Derived Neurotrophic Factor and Memory Impairment Induced by Lipopolysaccharide in Rats

2021 ◽  
Author(s):  
Narges Marefati ◽  
Farimah Beheshti ◽  
Farzaneh Vafaee ◽  
Moslem Barabadi ◽  
Mahmoud Hosseini
Keyword(s):  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Brain Derived Neurotrophic Factor ◽  
Neuro Inflammation

scholarly journals Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yoshito Mizoguchi ◽  
Hiroshi Yao ◽  
Yoshiomi Imamura ◽  
Manabu Hashimoto ◽  
Akira Monji
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Brain Derived Neurotrophic Factor ◽  
Community Dwelling ◽  
Hippocampal Atrophy ◽  
Age Related ◽  
Behavioral Memory ◽  
Community Dwelling Older Adults

Abstract The beneficial effects of brain-derived neurotrophic factor (BDNF)—a member of the neurotrophin family—on cognitive function or dementia are well established in both rodents and human beings. In contrast, little is known about the association of proBDNF—a precursor protein with opposing neuronal effects of BDNF—with cognitive function in non-demented older adults. We analyzed brain magnetic resonance imaging findings of 256 community-dwelling older adults (mean age of 68.4 years). Serum BDNF and proBDNF levels were measured by quantitative enzyme-linked immunosorbent assay. Logistic regression analysis revealed that older age, less physical activity, hippocampal atrophy, and lower BDNF levels were independently associated with memory impairment determined by the Rivermead Behavioral Memory Test. Path analysis based on structural equation modeling indicated that age, sport activity, hippocampal atrophy and BDNF but not proBDNF were individually associated with Rivermead Behavioral Memory Test scores. These findings suggest that impaired BDNF function, in addition to physical inactivity and hippocampal atrophy, is associated with age-related memory impairment. Therefore, BDNF may be a potential target for dementia prevention.

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

2014 ◽  
Vol 268 ◽  
pp. 88-93 ◽  
Author(s):  
Kazuya Fukumoto ◽  
Hiroyuki Mizoguchi ◽  
Hideyuki Takeuchi ◽  
Hiroshi Horiuchi ◽  
Jun Kawanokuchi ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Amyloid Β ◽  
Brain Derived Neurotrophic Factor

Extract of the Aerial Part of Polygala tenuifolia Attenuates d-Galactose/NaNO2-induced Learning and Memory Impairment in Mice

Planta Medica ◽  
2020 ◽  
Vol 86 (18) ◽  
pp. 1389-1399
Author(s):  
Dian Zhang ◽  
Xiao Wang ◽  
Rong Li ◽  
Lin Wang ◽  
Zihao Zhou ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Aerial Part ◽  
Brain Derived Neurotrophic Factor ◽  
Latency Time ◽  
Receptor Kinase ◽  
Model Group ◽  
Age Related ◽  
Polygala Tenuifolia

AbstractAlzheimerʼs disease, one of the most common types of age-related dementia, is characterized by memory deterioration and behavior disorder. The aboveground part of Polygala tenuifolia is a traditional Chinese medicine used for the treatment of amnesia. This study was conducted to investigate the ameliorating effect of the aerial part of P. tenuifolia on d-galactose/NaNO2-induced learning and memory impairment in mice. d-galactose (120 mg/kg) and NaNO2 (90 mg/kg) were injected intraperitoneally for 60 days to induce learning and memory impairment in mice. The aerial part of P. tenuifolia (25, 50, and 100 mg/kg) and piracetam (200 mg/kg) were simultaneously administered orally on days 15 – 60. Results of this study showed that aerial part of P. tenuifolia significantly decreased the latency time and increased the number of platform crossings in the Morris water maze compared with the Model group. Moreover, the aerial part of P. tenuifolia significantly increased the latency time and decreased the error frequency in the step-down and step-through tests compared with the Model group. Meanwhile, the aerial part of P. tenuifolia was able to regulate the cholinergic system by increasing the levels of ACh and ChAT and decreasing the level of AChe. The aerial part of P. tenuifolia also significantly attenuated the levels of interleukin-1 beta and malonaldehyde and enhanced the interleukin-10 and glutathione levels and superoxide dismutase activity. Furthermore, treatment with aerial part of P. tenuifolia increased the protein and mRNA expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the hippocampus. These results suggest that the aerial part of P. tenuifolia can ameliorate learning and memory impairments by modulating cholinergic activity, inhibiting neuroinflammation and oxidative stress, and regulating the brain-derived neurotrophic factor and tropomyosin receptor kinase B signaling pathway.

Low Plasma Brain-Derived Neurotrophic Factor and Childhood Physical Neglect Are Associated with Verbal Memory Impairment in Major Depression—A Preliminary Report

2008 ◽  
Vol 64 (4) ◽  
pp. 281-285 ◽  
Author(s):  
Rodrigo Grassi-Oliveira ◽  
Lilian Milnitsky Stein ◽  
Rodrigo Pestana Lopes ◽  
Antonio L. Teixeira ◽  
Moisés Evandro Bauer
Keyword(s):  
Major Depression ◽  
Verbal Memory ◽  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Preliminary Report ◽  
Brain Derived Neurotrophic Factor ◽  
Physical Neglect

scholarly journals Interferon-Gamma and Interleukin-1Beta Enhance the Secretion of Brain-Derived Neurotrophic Factor and Promotes the Survival of Cortical Neurons in Brain Injury

2020 ◽  
Vol 15 ◽  
pp. 263310552094708
Author(s):  
Ebtesam M Abd-El-Basset ◽  
Muddanna Sakkattu Rao ◽  
Ameerah Alsaqobi
Keyword(s):  
Brain Injury ◽  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Stab Wound ◽  
Brain Derived Neurotrophic Factor ◽  
Interferon Γ ◽  
Fluoro Jade B ◽  
Ifn Γ ◽  
Interleukin 1Beta ◽  
Neuro Inflammation

Neuro-inflammation is associated with the production of cytokines, which influence neuronal and glial functions. Although the proinflammatory cytokines interferon-γ (IFN-γ) and interleukin-1Beta (IL-1β) are thought to be the major mediators of neuro-inflammation, their role in brain injury remains ill-defined. The objective of this study was to examine the effect of IFN-γ and IL-1β on survival of cortical neurons in stab wound injury in mice. A stab wound injury was made in the cortex of male BALB/c mice. Injured mice (I) were divide into IFN-γ and IL-1β treatment experiments. Mice in I + IFN-γ group were treated with IFN-γ (ip, 10 µg/kg/day) for 1, 3 and 7 days and mice in I + IL-1β group were treated with 5 IP injection of IL-1β (0.5 µg /12 h). Appropriate control mice were maintained for comparison. Immunostaining of frozen brain sections for astrocytes (GFAP), microglia (Iba-1) and Fluoro-Jade B staining for degenerating neurons were used. Western blotting and ELISA for brain-derived neurotrophic factor (BDNF) were done on the tissues isolated from the injured sites. Results showed a significant increase in the number of both astrocytes and microglia in I + IFN-γ and I + IL-1β groups. There were no significant changes in the number of astrocytes or microglia in noninjury groups (NI) treated with IFN-γ or IL-1β. The number of degenerating neurons significantly decreased in I + IFN-γ and I + IL-1β groups. GFAP and BDNF levels were significantly increased in I + IFN-γ and I + IL-1β groups. Interferon-γ and IL-1β induce astrogliosis, microgliosis, enhance the secretion of BDNF, one of the many neurotrophic factors after brain injury, and promote the survival of cortical neurons in stab wound brain injury.

scholarly journals Brain-derived neurotrophic factor (BDNF)

2019 ◽  
pp. 83-88
Author(s):  
А.А. Пальцын
Keyword(s):  
Emotional Disorders ◽  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Emotional State ◽  
Hypotensive Effect ◽  
Brain Derived Neurotrophic Factor ◽  
Carbohydrate And Lipid Metabolism ◽  
Treatment Of Hypertension ◽  
The Brain ◽  
State Stress

Сегодня нейротрофический фактор мозга (BDNF) - вещество очень популярное. Большой интерес к белку объясняется его участием в важнейших для жизни и здоровья процессах: нервной регуляции, углеводном и липидном обмене, адаптации к физическим нагрузкам. Вещество участвует в регуляции эффективности профилактических и лечебных процедур, эмоционального состояния, стрессоустойчивости, нейропластичности, нейрогенеза. BDNF - главный регулятор действия самого универсального и, часто, самого эффективного лечебного средства - физических нагрузок. Следовательно, он становится веществом первостепенного значения в одной из самых актуальных проблем современной медицины - профилактике и лечении гипертонической болезни. Кроме гипотензивного действия, доказана эффективность BDNF при обусловленных гипертонией когнитивных нарушениях, шизофрении, дефектах памяти, эмоциональных расстройствах. Today, the brain-derived neurotrophic factor (BDNF) is a very popular substance. The high interest to this protein is due to its participation in key processes for life and health, including nervous regulation, carbohydrate and lipid metabolism, and exercise capacity. BDNF regulates preventive and therapeutic efficacy of exercise, emotional state, stress resistance, neuroplasticity, and neurogenesis. BDNF determines the action of the most universal and often the most effective therapeutic means, physical exercise. Therefore, BDNF appears to be the substance of primary importance for a burning issue of current medicine, prevention and treatment of hypertension. In addition to its hypotensive effect, BDNF has proved to be beneficial in hypertension-induced cognitive decline, schizophrenia, memory impairment, and emotional disorders.

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